Heart and Blood Diseases

All Conditions

Diseases and Abnormalities at or Before Birth

Neoplasms

Rare Diseases

Heart Diseases

Heart Defects, Congenital

Heart Neoplasms

Congenital Abnormalities

Cardiovascular Abnormalities

Thoracic Neoplasms

Heart Tumor

Brian Kogon, MD

The purpose of this study is to define the natural history of untreated cardiac tumors, study the pathology of primary cardiac tumors, review the surgical treatment and results of primary cardiac tumors and to determine the prognosis for these tumors.

Primary cardiac tumors in children are extremely rare. Benign tumors are typically myxomas, lipomas, and rhabdomyomas, while malignant tumors are typically angiosarcomas and rhabdomyosarcomas. Due to the rarity of these tumors, it is difficult to gather meaningful information regarding their natural history, pathology and treatment.

The primary aims are to define the natural history of untreated cardiac tumors, study the pathology of primary cardiac tumors, review the surgical treatment and results of primary cardiac tumors and to determine the prognosis for these tumors. The secondary aims are to discover patterns and consistencies among primary cardiac tumors and to define the best treatment options for these patients. The study will be conducted through a retrospective chart review of about 70 patients.

Cardiac Tumors in Children

Children's Healthcare of Atlanta

patients who are diagnosed as cardiac myxoma

patients who are diagnosed as cardiac fibroma

patients who are diagnosed as cardiac lipoma

patients who are diagnosed as cardiac hemangioma

patients who are diagnosed as cardiac malignant tumor

Guoliang Li

Yang Yan

This study aims to retrospectively and prospectively collect clinical and biological specimen data from patients with cardiac tumors who meet the inclusion and exclusion criteria. Various techniques, including general molecular biology analysis and multi-omics analysis, will be used to construct a prognostic model for cardiac tumors.

This study aims to construct a retrospective-prospective long-term follow-up cohort and management system for cardiac tumors through a multi-centre collaborative network. The duration of the study will be divided into retrospective and prospective components. The retrospective study will collect cases of cardiac tumors from 2003-2022; the prospective study is expected to collect cases of cardiac tumors from 2022-2030. The study is expected to assess the disease characteristics, progression patterns, clinical features, natural course and long-term prognosis of cardiac tumors.

Characteristics of Cardiac Tumor and the Risk Stratification of Subsequent Adverse Events (UNIQUE)

Characteristics of Cardiac Tumor and the Risk Stratification of Subsequent Adverse Events (UNIQUE): an Investigator-initiated, National, Multicenter, Retrospective-prospective, Cohort Study

MACCE (major adverse cardiac and cerebrovascular events) including all-cause death, myocardial infarction, coronary revascularization surgery and stroke. The MACCE will be assessed from the medical records.

All-cause death diagnosed by clinical doctors will be assessed from the medical records

Myocardial infarction diagnosed by clinical doctors will be assessed from the medical records

Coronary revascularization surgery completed by clinical doctors will be assessed from the medica records

Stroke diagnosed by clinical doctors will be assessed from the medical records

First Affiliated Hospital Xi'an Jiaotong University

Symptoms and General Pathology

Nervous System Diseases

Myocardial Infarction

Infarction

Stroke

Ischemic Stroke

Ischemia

Atrial Fibrillation

Endocarditis

Foramen Ovale, Patent

Embolic Stroke

Cerebral Infarction

Cerebrovascular Disorders

Brain Diseases

Central Nervous System Diseases

Vascular Diseases

Arrhythmias, Cardiac

Necrosis

Coronary Artery Disease

Myocardial Ischemia

Brain Infarction

Brain Ischemia

Heart Septal Defects

Heart Septal Defects, Atrial

Natriuretic Agents

All Drugs and Chemicals

Natriuretic Peptide, Brain

N,N-dimethylarginine

Enzyme Inhibitors

Patients with stroke of undetermined cause age 18-65

ADMA, NTproBNP, IL-6, Adiponectina, Leptine, Syndecan, Resistin

ADMA (asymmetric dimethylarginine) , NTproBNP (N-terminal pro b-type natriuretic peptide), IL-6 (Interleukin 6), Adiponectina, Leptine, Syndecan, Resistin

A stroke is the second cause of deaths after heart attack, one of the most important causes of malfunction as far as adults are concerned and the second as for the frequency cause of dementia. In spite of a possibility of the therapy of stroke ( tissue plasminogen activator) and recognized most of risk factors there is expected that incidence rate on stroke connected with ageing of the society will be growing. It will cause medical and social consequences.

There are many of potential causes of cardiac strokes, which are not entirely examined.

More over many cryptogenic strokes are presumed to have an embolic etiology, and the frequent cause of these kind of strokes at young age is probably the mechanism of paradoxical embolism through patent foramen ovale.

As far as the investigators are concerned, at present there is lack of any recommendations for these scientific hypothesis.

A stroke is the second cause of deaths after heart attack, one of the most important causes of malfunction as far as adults are concerned and the second as for the frequency cause of dementia. In spite of a possibility of the therapy of stroke ( tissue plasminogen activator) and recognized most of risk factors there is expected that incidence rate on stroke connected with ageing of the society will be growing. It will cause medical and social consequences.

The risk factors of stroke can be divided into alterable and not alterable. Importantly, the not alterable factors are: age, sex, race and genetic factors. After the age of 55 the risk of stroke grows twice in every decade of life. Moreover, it was alleged that incidence rate on stroke is more frequent at women than at men. At the black race the incidence rate on stroke is twice more frequent than at white race.

Well- known are also genetic syndromes connected with strokes like s. MELAS or CADASIL.

Well- known alterable factors are:

* hypertension
* coronary disease
* atrial fibrillation
* hypercholesterolemia
* diabetes
* nicotinism
* blood clotting disorder
* alcoholism
* TIA (transient ischemic attack) or previous former stroke
* asymptomatic stenosis of internal carotid artery

Cardiogenic stroke is a stroke caused by embolic material, which was created in cardiac cavities or on cardiac valves. They comprised 11% of all strokes and 25% of ischemic strokes. Additionally, among patients over 80 years old cardiac causes are responsible for even 40% of all ischemic strokes and half of cardiogenic strokes is caused of atrial fibrillation. Among young people (below 45 years old) about 50% of strokes are cardiogenic and are connected with paradoxical embolism at patients with patent foramen ovale.

Furthermore, cardiac- brain embolism is a result of:

* structural defect of cavities and valves of heart
* arrhythmia
* disturbances of movability of walls of the heart and function of endocardium which leads to increased risk of the risk of parietal thrombus
* cardiac insufficiency

There are many of potential causes of cardiac strokes, which are not entirely examined as for example:

* small pockets of intra- atrial septum
* structures in dextral atrium like Eustachian valve or Chiari network
* there is also a theory that even enlargement of left atrium may be the cause of brain stroke
* aneurysm of intra- atrial septum.

As far as the investigators are concerned, at present there is lack of any recommendations for these scientific hypothesis.

Available data suggest that in the comparison with atherosclerosis and lacunar strokes cardiogenic strokes characterize with high mortality ranging of 27%. Also the risk of relapse is higher than in strokes of other etiology.

Nevertheless, unfortunately, in spite of wide diagnostics at about 25-30% of patients with ischemic stroke the cause is unknown. This kind of stroke is called cryptogenic stroke or stroke with undefined etiology.

They constitute almost half of all ischemic stroke at young patients (below 55 years old). Many cryptogenic strokes are presumed to have an embolic etiology, and the frequent cause of these kind of strokes at young age is probably the mechanism of paradoxical embolism through patent foramen ovale.

To conclude, currently there aren't researches defining recommendations for long- lasting treatment patients with rare causes of strokes.

Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis

NTproB (N-terminal pro b-type natriuretic peptide)

Medical University of Lodz

Principal Investigator

Heart Failure

Cardiomyopathies

Myocarditis

Endocardiomyocardial biopsy

XiaoHong PAN

In this study, patients with endocardial myocardial biopsy were selected to observe the safety of the operation, and pathological examination was performed. If necessary, special tests such as viral examination, mass spectrometry and molecular biology were performed to confirm the diagnosis, and follow-up was performed.

Clinical Study of Endocardial Myocardial Biopsy

incidences of MACE-4(cardiovascular death, myocardial infarction, stroke and hospitalized unstable angina)

Second Affiliated Hospital, School of Medicine, Zhejiang University

Coronary Disease

Constriction, Pathologic

Aortic Valve Stenosis

Aortic Valve Disease

Arteriosclerosis

Arterial Occlusive Diseases

Heart Valve Diseases

Ventricular Outflow Obstruction

Patients undergoing aortic valve replacement

Patients undergoing cardiac surgery for indication other than above

Cardiac surgery

Tuomas O Kiviniemi, MD, PhD

Jarmo Gunn, MD, PhD

The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.

The investigators aim to A) compare atrial cardiomyopathy findings from the tissue samples to clinical phenotype and adverse events B) study the association of genetic defects predisposing to atrial fibrillation with atrial cardiomyopathy findings in the tissue samples C) assess the role of inflammation in atrial fibrillation by comparing circulating cytokine profiles, purinergic signaling and atrial cardiomyopathy findings in tissue samples.

Atrial appendage, valves, ascending aorta, pericardium

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Cardiac Tumors in Children	NCT00215085	Congenital Hear...		-	Children's Healthcare of Atlanta
Characteristics of Cardiac Tumor and the Risk Stratification of Subsequent Adverse Events (UNIQUE)	NCT06100328	Cardiac Tumor		3 Years - 80 Years	First Affiliated Hospital Xi'an Jiaotong University
Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis	NCT03377465	Embolic Stroke ... Ischemic Stroke Atrial Fibrilla... Myocardial Infa... Cardiac Tumor Endocarditis Patent Foramen ...	ADMA (asymmetri...	18 Years - 65 Years	Medical University of Lodz
Clinical Study of Endocardial Myocardial Biopsy	NCT05718128	Myocarditis Cardiomyopathie... Heart Failure Cardiac Tumor Endocardiomyoca...	Endocardiomyoca...	18 Years - 80 Years	Second Affiliated Hospital, School of Medicine, Zhejiang University
Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis	NCT03377465	Embolic Stroke ... Ischemic Stroke Atrial Fibrilla... Myocardial Infa... Cardiac Tumor Endocarditis Patent Foramen ...	ADMA (asymmetri...	18 Years - 65 Years	Medical University of Lodz
Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients	NCT03444259	Atrial Fibrilla... Coronary Artery... Aortic Valve St... Aortic Valve Di... Mitral Valve Di... Cardiac Arrythm... Cardiac Tumor Cardiac Surgery	Cardiac surgery	18 Years -	University of Turku

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