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Brief Title: Photochemical Tissue Bonding
Official Title: Photochemical Tissue Bonding (PTB) for Excisional Wound Healing
Study ID: NCT00586040
Brief Summary: The broad aim of this study is to evaluate the efficacy of photochemical tissue bonding (PTB) for the closure of skin excisions. We will test the hypothesis that full thickness skin excisions treated with PTB can heal with less scarring than those treated with the conventional suture closure method.
Detailed Description: Hypertrophic scarring is a frequent endpoint after traditional surgical excision of skin cancers of the chest. These scars create significant long-term morbidity to the patient. There is a clinical need for an alternative treatment that would reduce factors associated with hypertrophic and possibly keloid scar formation by providing minimal tension, low infection risk and an absence of foreign body material. This would result in a normal appearing and healed scar without associated patient morbidity. Photochemical tissue bonding may provide this alternate treatment. PTB differs from sutures by continuously joining the tissue surfaces on a molecular level rather than only at discrete suture points. In addition, PTB does not incite foreign body reactions nor create tissue injury during passage of the needle and tying a knot, injuries that may initiate scarring.
Minimum Age: 20 Years
Eligible Ages: ADULT
Sex: ALL
Healthy Volunteers: Yes
Massachusetts General Hospital, Boston, Massachusetts, United States
Name: Irene E Kochevar, PhD
Affiliation: Massachusetts General Hospital
Role: PRINCIPAL_INVESTIGATOR