Spots Global Cancer Trial Database for Normal Saline Vrs Balanced i.v. Fluids in Neurosurgery

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Trial Identification

Brief Title: Normal Saline Vrs Balanced i.v. Fluids in Neurosurgery

Official Title: Comparison of Normal Saline and Balanced Crystalloid Intravenous Therapy During Neurosurgery

Study ID: NCT03429127

Conditions

Benign Neoplasms

Vascular Malformations, Brain

Interventions

Normal saline

Balanced fluid

Study Description

Brief Summary: The purpose of this study was to investigate whether the balanced fluids therapy change plasma osmolality in neurosurgical procedures due to brain tumors, meningeomas and arterio-venous malformation.

Detailed Description: Normal saline or 0.9% sodium chloride solution is the most commonly used intravenous fluid worldwide and its composition are 154 mmol Na+ and 154 mmol Cl- per litter with osmolality of 308 mOsmol/L. That composition is not "normal" because plasma contains potassium in range between 137-146 mmol/L, and chloride in range between 98-106 mmol/L, with plasma osmolality of 280-295 mOsmol/kg. Recently published data suggested detrimental effects of chloride rich fluids on renal blood flow and glomerular filtration rate, urine output and acute kidney injury. One alternative to saline solution is a buffered, balanced, crystalloid solution with an electrolyte composition similar to plasma and osmolality between 286-295 mOsmol/L. Someone could indicate that such balanced solutions are not suitable for neurosurgical patients because of a possible impact on the brain edema development.