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Plasma-lyte 148

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The patients in this group will receive up to 2000 ml of normal saline during neurosurgical operation.

The patients in this group will receive up to 2000 ml of balanced fluids during neurosurgical operation.

Plasma osmolality, acid base status and electrolytes after application up to 2000 ml of normal saline during neurosurgical operation

Normal saline

Plasma osmolality, acid base status and electrolytes after application of up to 2000 ml balanced fluids during neurosurgical operation

Balanced fluid

Natasa Kovac, M.D.

Inga Mladic Batinica, M.D.

The purpose of this study was to investigate whether the balanced fluids therapy change plasma osmolality in neurosurgical procedures due to brain tumors, meningeomas and arterio-venous malformation.

Normal saline or 0.9% sodium chloride solution is the most commonly used intravenous fluid worldwide and its composition are 154 mmol Na+ and 154 mmol Cl- per litter with osmolality of 308 mOsmol/L. That composition is not "normal" because plasma contains potassium in range between 137-146 mmol/L, and chloride in range between 98-106 mmol/L, with plasma osmolality of 280-295 mOsmol/kg. Recently published data suggested detrimental effects of chloride rich fluids on renal blood flow and glomerular filtration rate, urine output and acute kidney injury. One alternative to saline solution is a buffered, balanced, crystalloid solution with an electrolyte composition similar to plasma and osmolality between 286-295 mOsmol/L. Someone could indicate that such balanced solutions are not suitable for neurosurgical patients because of a possible impact on the brain edema development.

Normal Saline Vrs Balanced i.v. Fluids in Neurosurgery

Comparison of Normal Saline and Balanced Crystalloid Intravenous Therapy During Neurosurgery

Whether the applied fluids affect plasma osmolality

Changes in acid base pH status after each 500 ml of normal saline vrs. balanced fluid

Electrolytes changes (sodium and chloride) after each 500 ml of normal saline vrs. balanced fluid

Sisters of Mercy University Hospital

Clinical Hospital Centre Zagreb

Natasa Kovac, M.D., Anesthesiologyst and intensive care medicine subspecialist

Questionnaires completed before and after inpatient rehabilitation. Questionnaires ask about daily living activity performance, expectation of how well daily living activities will be performed after completion of inpatient rehabilitation, symptoms experienced in the past 24 hours, and physical, functional, social, and emotional well-being.

Questionnaires completed before and after inpatient rehabilitation. Questionnaires ask about daily living activity performance, expectation of how well daily living activities will be performed after completion of inpatient rehabilitation, symptoms experienced in the past 24 hours, and physical, functional, social, and emotional well-being. These questionnaires should take about 15 minutes total to complete.

Questionnaires

Ekta Gupta, MD

The goal of this research study is to learn if there is a difference between your expectations of how well you will perform daily living activities after short-term inpatient rehabilitation and the doctor's expectations of how well you will perform daily living activities.

If you agree to take part in this study, you will complete questionnaires before your inpatient rehabilitation and after you complete inpatient rehabilitation. The questionnaires will ask about how well you currently perform daily living activities, your expectation of how well you will perform daily living activities after you complete inpatient rehabilitation, your symptoms in the past 24 hours, and your physical, functional, social, and emotional well-being. These questionnaires should take about 15 minutes total to complete.

Information from your medical record (such as your age, gender, religion, cancer diagnosis, stage of cancer, and so on) will be collected.

Length of Study:

You participation on this study will be over after you complete the questionnaires.

This is an investigational study.

Up to 111 participants will take part in this study. All will be enrolled at MD Anderson.

Expectations Regarding Mobility and Self-Care

Assessment of Expectations Regarding Mobility and Self-Care Between Physiatrists and Oncology Patients

M.D. Anderson Cancer Center

Patients treated at NCI with available tissue samples.

Paula A Carter, R.N.

William D Figg, Pharm.D.

BACKGROUND:

Cancer of any type is a serious disease and despite all the progress made from past research, there is still much that is poorly understood at the molecular level. Recent advances in biomedical technology platforms have emerged as critical tools for accelerating personalized medicine. The collection of human tissue specimens has been an invaluable resource for conducting translational cancer research using these developing technologies. The ultimate goal is to understand the molecular indicators of cancer development and progression. While it is ideal to be able to study clinical samples, specifically tissue biopsies, they are however precious and are often difficult to obtain in sufficient quantities or numbers to conduct proteomic or molecular profiling studies. There exists, however, a vast archive of pathologically characterized clinical samples in the form of formalin-fixed paraffin-embedded tissue blocks. The preservation of these tissue blocks and/or slides for long-term (years) storage is an important asset that aids in translational and clinical research. This protocol will describe the procedures for receiving, labeling and storing paraffin-embedded tissue blocks and/or slides until they are needed for future analysis. When blocks are ready for analysis, the requestor will then follow the IRB protocol specific to that study.

OBJECTIVE:

- To obtain tissue blocks and slides from outside pathology departments for cancer patients being treated at the Medical Oncology Branch (MOB) and Affiliates Center for Cancer Research (CCR), National Cancer Institute (NCI) in order to store them for future studies and analysis (e.g., using molecular technology platforms).

ELIGIBILITY:

- Patients suspected of having, or with biopsy proof of malignant disease will be evaluated in the Medical Oncology Branch and Affiliates Clinics, NCI.

DESIGN:

* Tissue blocks and slides will be acquired from outside pathology departments and received by the Clinical Pharmacology Program of the MOB/CCR/NCI for coding.
* Bar-coded tissue blocks and slides will then be transferred to the Laboratory of Pathology/CCR/NCI for proper long-term storage.

Background

* Cancer of any type is a serious disease and despite all the progress made from past research, there is still much that is poorly understood at the molecular level.
* Recent advances in biomedical technology platforms have emerged as critical tools for accelerating personalized medicine.
* The collection of human tissue specimens has been an invaluable resource for conducting translational cancer research using these developing technologies.
* The ultimate goal is to understand the molecular indicators of cancer development and progression.
* While it is ideal to be able to study clinical samples, specifically tissue biopsies, they are however precious and are often difficult to obtain in sufficient quantities or numbers to conduct proteomic or molecular profiling studies.
* There exists, however, a vast archive of pathologically characterized clinical samples in the form of formalin-fixed paraffin-embedded tissue blocks.
* The preservation of these tissue blocks and/or slides for long-term (years) storage is an important asset that aids in translational and clinical research.
* This protocol will describe the procedures for receiving, labeling and storing paraffinembedded tissue blocks and/or slides until they are needed for future analysis.
* When blocks are ready for analysis, the requestor will then follow the IRB protocol specific to that study.

Objective

-To obtain tissue blocks and slides from outside pathology departments for cancer patients being treated at the Genitourinary Malignancies Branch (GMB) and Affiliates Center for Cancer Research (CCR), National Cancer Institute (NCI) in order to store them for future studies and analysis (e.g., using molecular technology platforms).

Eligibility

-Patients suspected of having, or with biopsy proof of malignant disease will be evaluated in the Genitourinary Malignancies Branch (GMB) and Affiliates Clinics, NCI.

Design

* This protocol is not a research study.
* Tissue blocks and slides will be acquired from outside pathology departments and received by the Clinical Pharmacology Program of the OCD/CCR/NCI for coding.
* Bar-coded tissue blocks and slides will then be transferred to the Laboratory of Pathology/CCR/NCI for proper long-term storage.

Collection of Tissue Blocks or Slides From Patients With Cancer

.All IPD recorded in the medical record will be shared with intramural investigators upon request.

To obtain tissue blocks and slides from outside pathology departments for cancer patients being treated at the Genitourinary Malignancies Branch (GMB)Medical Oncology Branch (MOB) and Affiliates Center for Cancer Research (CCR), National Cancer Institute (NCI) in order to store them for future studies and analysis (e.g., using molecular technology platforms).

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Normal Saline Vrs Balanced i.v. Fluids in Neurosurgery	NCT03429127	Benign Neoplasm... Vascular Malfor...	Normal saline Balanced fluid	18 Years -	Clinical Hospital Centre Zagreb
Expectations Regarding Mobility and Self-Care	NCT02911064	Benign Neoplasm... Malignant Neopl...	Questionnaires	18 Years -	M.D. Anderson Cancer Center
Expectations Regarding Mobility and Self-Care	NCT02911064	Benign Neoplasm... Malignant Neopl...	Questionnaires	18 Years -	M.D. Anderson Cancer Center
Collection of Tissue Blocks or Slides From Patients With Cancer	NCT02810405	Tumor Carcinogens Neoplasm, Benig... Benign Neoplasm... Cancer		18 Years -	National Institutes of Health Clinical Center (CC)

Spots Global Cancer Trial Database for benign neoplasms