Spots Global Cancer Trial Database for Cryosurgery and Radiation Therapy in Treating Patients With Painful Bone Metastases

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Trial Identification

Brief Title: Cryosurgery and Radiation Therapy in Treating Patients With Painful Bone Metastases

Official Title: A Pilot Study of The Tandem Treatment of Painful Osseous Metastases With Cryoablation Followed by Radiation Therapy

Study ID: NCT01767935

Conditions

Bone Metastases

Pain

Interventions

cryosurgery

radiation therapy

quality-of-life assessment

Study Description

Brief Summary: This pilot clinical trial studies cryosurgery and radiation therapy in treating patients with painful bone metastases. Cryosurgery kills tumor cells by freezing them. Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells and shrink tumors. Giving cryosurgery together with radiation therapy may kill more tumor cells

Detailed Description: PRIMARY OBJECTIVES: I. To assess the potential for efficacy and safety of combining percutaneous computed tomography (CT)-guided cryoablation and radiotherapy for the palliation of osseous metastases. OUTLINE: Patients undergo cryosurgery. Beginning 2 weeks later, patients undergo 1, 10, or 15 fractions of radiation therapy 5 days per week for 1-3 weeks. Treatment continues in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up at 24 hours and weeks 1-2, 4, 12, 18, and 24.