Spots Global Cancer Trial Database for Resting-State Functional MRI in Glioma Patients Before and After Surgery

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Resting-State Functional MRI in Glioma Patients Before and After Surgery

Official Title: Resting-State Functional MRI in Glioma Patients Before and After Surgery

Study ID: NCT03964909

Conditions

Brain Mass

Glioma

Interventions

Functional Magnetic Resonance Imaging

Magnetic Resonance Imaging

Resting State Functional Connectivity Magnetic Resonance Imaging

Study Description

Brief Summary: This clinical trial studies how well resting-state functional magnetic resonance imaging (MRI) and cerebrovascular reactivity (CVR) MRI performed before and after surgery works in measuring the effects on language in patients with glioma. Mapping language function before brain tumor resection is crucial for preventing post-surgical deficits and maximizing restoration of language function following surgery. Additional imaging, such as resting-state functional MRI and CVR MRI, may help measure the language network in the brain before surgery and any effects on language function after surgery.

Detailed Description: PRIMARY OBJECTIVES: I. To develop a reliable platform for preoperative mapping of language networks using resting-state-functional magnetic resonance imaging (rs)-fMRI in glioma patients. SECONDARY OBJECTIVES: I. To explore the reorganizations of resting-state functional connectivity (FC) and their relation to neuropsychological outcomes in glioma patients after surgery. OUTLINE: Patients undergo standard of care functional (f)MRI, CVR MRI over 3 minutes, and rs-fMRI over 6 minutes 1 month before and within 6 weeks after standard of care surgery. After completion of study, patients are followed up at 4-6 weeks.