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Brief Title: SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI
Official Title: Stereotactic Radiotherapy for Non-small Cell Lung Cancer With Oligo-residual Intracranial Disease After First-line Third-generation EGFR Inhibitors: a Multicenter, Randomized Clinical Trial.
Study ID: NCT06020066
Brief Summary: Despite the impressive response rate to third-generation EGFR-TKIs, resistance inevitably develops in most patients. Stereotactic radiotherapy plays a growing role in the management of patients with brain metastasis. This study aims to evaluate the efficacy and safety of stereotactic radiotherapy for oligo-residual intracranial disease after first-line third-generation EGFR Inhibitors.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Fudan University Shanghai Cancer Center, Shanghai, Shanghai, China
Name: Zhengfei Zhu, MD
Affiliation: Fudan University
Role: PRINCIPAL_INVESTIGATOR
Name: Xuwei Cai
Affiliation: Shanghai Chest Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Qian Chu
Affiliation: Tongji Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Xiaorong Dong
Affiliation: Wuhan Union Hospital, China
Role: PRINCIPAL_INVESTIGATOR
Name: Lin Wu
Affiliation: Hunan Cancer Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Rongrong Zhou
Affiliation: Xiangya Hospital of Central South University
Role: PRINCIPAL_INVESTIGATOR
Name: Guang Han
Affiliation: Hubei Cancer Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Hui Zhu
Affiliation: Shandong Cancer Hospital and Institute
Role: PRINCIPAL_INVESTIGATOR
Name: Jinjun Ye
Affiliation: Jiangsu Cancer Institute & Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Xiaojia Cui
Affiliation: The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China
Role: PRINCIPAL_INVESTIGATOR
Name: Guomei Tai
Affiliation: The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China
Role: PRINCIPAL_INVESTIGATOR
Name: Zhiyong Yuan
Affiliation: Tianjin Medical University Cancer Institute and Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Dejun XIng
Affiliation: Jilin Provincial Tumor Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Jichen Ren
Affiliation: Jilin Provincial Tumor Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Jiancheng Li
Affiliation: Fujian Medical University Cancer Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Yanyang Wang
Affiliation: General Hospital of Ningxia Medical University
Role: PRINCIPAL_INVESTIGATOR
Name: Chuangzhou Rao
Affiliation: Ningbo No.2 Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Bing Lu
Affiliation: The Affiliated Hospital Of Guizhou Medical University
Role: PRINCIPAL_INVESTIGATOR
Name: Zhongyi Dong
Affiliation: Nanfang Hospital, Southern Medical University
Role: PRINCIPAL_INVESTIGATOR
Name: Jiwei Liu
Affiliation: The First Affiliated Hospital of Dalian Medical University
Role: PRINCIPAL_INVESTIGATOR
Name: Zhenzhou Yang
Affiliation: The Second Affiliated Hospital of Chongqing Medical University
Role: PRINCIPAL_INVESTIGATOR
Name: Hongqing Zhuang
Affiliation: Peking University Third Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Anwen Liu
Affiliation: Nanchang University Second Affiliated Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Haihua Yang
Affiliation: Taizhou Hospital Affiliated to Wenzhou Medical University
Role: PRINCIPAL_INVESTIGATOR
Name: Fang Liu
Affiliation: Chinese PLA General Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Yong Mao
Affiliation: Affiliated Hospital of Jiangnan University
Role: PRINCIPAL_INVESTIGATOR