Spots Global Cancer Trial Database for brain metastases
Every month we try and update this database with for brain metastases cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases | NCT04192981 | Brain Metastase... Leptomeningeal ... | GDC-0084 whole brain rad... | 18 Years - | Memorial Sloan Kettering Cancer Center | |
| Diffusion-weighted MRI to Predict Treatment Response in Stereotactic Radiotherapy of Central Nervous System (CNS) Metastases | NCT04700748 | Radiotherapy Brain Metastase... Sensitivity Radionecrosis | Brain metastase... | 18 Years - | Lund University Hospital | |
| Open Label, Prospective Study to Investigate Efficacy and Safety of AZD9291 in BM From NSCLC Patients With EGFR T790M | NCT02972333 | EGFR-TKI Resist... Nonsmall Cell L... AZD9291 Brain Metastase... | AZD9291 80mg or... Radiation thera... | 18 Years - | Shandong Cancer Hospital and Institute | |
| Elective Simultaneous Modulated Accelerated Brain Radiation Therapy for NSCLCs With Limited Brain Metastases | NCT03414944 | Brain Metastase... | SMART-Brain | 18 Years - 75 Years | Shandong Cancer Hospital and Institute | |
| FSRT in Breast Cancer Patients With Brain Metastases | NCT04061408 | Breast Cancer Brain Metastase... | Fractionated st... | 18 Years - 70 Years | Fudan University | |
| Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer | NCT05452005 | Lung Cancer Lung Cancer Met... Brain Metastase... Non Small Cell ... | [18F]-αvβ6-BP | 18 Years - | University of California, Davis | |
| The Impact of Neurocognitive Function in Patients With Multiple Brain Metastases Receiving Whole Brain Radiation Therapy | NCT03626818 | Brain Metastase... | 18 Years - 75 Years | Guangdong Association of Clinical Trials | ||
| Contribution of the CEST Sequence in the Characterization of Radionecrosis of Brain Metastases of Pulmonary Origin | NCT05977803 | Brain Metastase... Radionecrosis Pulmonary Cance... | MRI with CEST s... | 18 Years - | Assistance Publique - Hôpitaux de Paris | |
| Retrospective Study of Ovarian Cancer Patients With Brain Metastasis | NCT01258881 | Ovarian Cancer Brain Metastase... | 25 Years - 80 Years | National Taiwan University Hospital | ||
| ANG1005 in Leptomeningeal Disease From Breast Cancer | NCT03613181 | Leptomeningeal ... Leptomeningeal ... Brain Metastase... HER2-negative B... | ANG1005 Physician's Bes... | 18 Years - | Angiochem Inc | |
| Lazertinib in Patients With NSCLC With Asymptomatic or Mild Symptomatic Brain Metastases After Failure of EGFR TKI. | NCT05326425 | Lung Neoplasms | lazertinib(YH25... | 20 Years - | Seoul St. Mary's Hospital | |
| SRS Sequential Sindilimab in Brain Metastasis of NSLSC | NCT04180501 | NSCLC Stage IV Brain Metastase... SRS Sintilimab | SRS sequential ... | 18 Years - 70 Years | Wuhan Union Hospital, China | |
| Surgery and Whole Brain Radiotherapy (RT) Versus Whole Brain Radiotherapy (RT) and Radiosurgery for 1-3 Resectable Brain Metastases | NCT01169129 | Metastases Cancer | surgery radiosurgery | 18 Years - 64 Years | Barretos Cancer Hospital | |
| Trial of Cabozantinib (XL184) in Non-Small Cell Lung Cancer With Brain Metastases | NCT02132598 | Non Small Cell ... Metastases to t... | cabozantinib | 18 Years - | University of Pittsburgh | |
| Bevacizumab, Etoposide and Cisplatin Followed by Whole Brain Radiotherapy in Breast Cancer With Brain Metastases | NCT02185352 | Breast Cancer Brain Metastase... | BEEP regimen | 20 Years - 75 Years | National Taiwan University Hospital | |
| Personalized Cellular Vaccine for Brain Metastases (PERCELLVAC3) | NCT02808416 | Brain Cancer Neoplasm Metast... | Personalized ce... | 18 Years - 65 Years | Guangdong 999 Brain Hospital | |
| CNS and Extracranial Tumor Tissues, CSF, and Blood From Patients With Melanoma Brain Metastases | NCT02058953 | Melanoma Brain Metastase... | Craniotomy sche... Collection for ... | 18 Years - | University of Pittsburgh | |
| PET/CT Evaluation of Primary and Metastatic Brain Tumors With a Novel Radioiodinated Phospholipid Ether Analogue I-NM404 | NCT01540513 | Glioblastoma Mu... Brain Metastase... | NM404 NM404 | 18 Years - | University of Wisconsin, Madison | |
| ZK219477 (Sagopilone) in Patients With Breast Cancer and Brain Metastases | NCT00496379 | Breast Cancer CNS Disease | ZK219477 | 18 Years - | Dana-Farber Cancer Institute | |
| A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors | NCT06209567 | High-grade Glio... Brain Metastase... Brain Metastase... | 68Ga-PSMA-11 PE... | 18 Years - | Memorial Sloan Kettering Cancer Center | |
| A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors | NCT06209567 | High-grade Glio... Brain Metastase... Brain Metastase... | 68Ga-PSMA-11 PE... | 18 Years - | Memorial Sloan Kettering Cancer Center | |
| Evaluation of Cabozantinib in Metastatic Renal Cell Carcinoma (mRCC) With Brain Metastases | NCT03967522 | Metastatic Rena... | Cabozantinib | 18 Years - | Centre Leon Berard | |
| Neurocognitive Outcomes In Patients Treated With Radiotherapy For Five Or More Brain Metastases | NCT01731704 | Brain Metastase... | Stereotactic ra... Whole brain rad... | 18 Years - | University of California, San Francisco | |
| Dual Perfusion Imaging for Characterizing Vascular Architecture of Brain Lesions | NCT05358340 | Brain Tumor Brain Metastase... | Dynamic suscept... | 18 Years - | University Health Network, Toronto | |
| Study of Cadonilimab Combined With Bevacizumab and Chemotherapy for Advanced Nonsquamous Non-small Cell Lung Cancer Patients With Untreated Brain Metastases | NCT05812534 | Non Small Cell ... Brain Metastase... | Cadonilimab | 18 Years - | Second Affiliated Hospital of Nanchang University | |
| Dose-escalation by Hypofractionated Stereotactic Radiotherapy for Brain Metastases in Non Small Cell Lung Cancer | NCT05588206 | Non Small Cell ... Stage IV Non-sm... Brain Metastase... | Hypofractionate... | 18 Years - | First People's Hospital of Hangzhou | |
| Study of Osimertinib in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation | NCT04233021 | Non Small Cell ... Leptomeningeal ... Brain Metastase... EGFR Activating... | Osimertinib | 18 Years - | Intergroupe Francophone de Cancerologie Thoracique | |
| Stereotactic Radiosurgery (SRS) for Multiple CNS Mets | NCT02567643 | Metastatic Canc... Brain Metastase... | Stereotactic Ra... | - | The Cooper Health System | |
| Imaging Perfusion Restrictions From Extracellular Solid Stress - An Open-label Losartan Study | NCT03951142 | Glioblastoma Brain Metastase... | Losartan | 18 Years - | Oslo University Hospital | |
| PCI for Patients With ES-SCLC After RCT:a Prospective Randomized Study | NCT04535739 | Small-cell Lung... | prophylactic cr... | 18 Years - 65 Years | ChineseAMS | |
| Radiosurgery Dose Reduction for Brain Metastases on Immunotherapy (RADREMI): A Prospective Pilot Study | NCT04047602 | Brain Tumor Brain Metastase... Brain Cancer | Reduced Dose SR... | 18 Years - | Indiana University | |
| Camrelizumab Combined With Local Treatment in NSCLC Patients With BM | NCT04291092 | NSCLC Stage IV Brain Metastase... Immunotherapy | Immunotherapy WBRT Chemotherapy | 18 Years - | Zhejiang Cancer Hospital | |
| Fractionated Stereotactic Radiotherapy (FSRT) in Treatment of Brain Metastases | NCT02187822 | Brain Metastase... Generalized Mal... Brain Lesions | TPI 287 Fractionated St... | 18 Years - | H. Lee Moffitt Cancer Center and Research Institute | |
| Sintilimab Combined With Bevacizumab for Brain Metastases From Non-small Cell Lung Cancer | NCT04213170 | Brain Metastase... Non Small Cell ... Sintilimab Bevacizumab | sintilimab | 18 Years - 75 Years | Sun Yat-sen University | |
| A Retrospective Study of the Efficacy and Safety of Lolatinib in ALK+ NSCLC Patients With Brain or Meningeal Metastasis | NCT06410040 | ALK-positive No... Brain Metastase... Meningeal Metas... | Lorlatinib | 18 Years - | Sichuan Cancer Hospital and Research Institute | |
| Radiotherapy Combined With PD-1 Inhibitors and Chemotherapy in the Treatment of NSCLC Patients With Symptomatic Brain Metastases | NCT05638425 | Non-small Cell ... Brain Metastase... | Radiotherapy co... | 18 Years - | Xiangya Hospital of Central South University | |
| Evaluation of Cabozantinib in Metastatic Renal Cell Carcinoma (mRCC) With Brain Metastases | NCT03967522 | Metastatic Rena... | Cabozantinib | 18 Years - | Centre Leon Berard | |
| Simvastatin Effect on Radiation Therapy of Brain Metastases | NCT02104193 | Brain Metastase... | simvastatin in ... radiation thera... | 18 Years - | Ain Shams University | |
| Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases | NCT03223922 | Brain Metastase... | whole brain rad... | 18 Years - 100 Years | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | |
| Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique | NCT05045950 | Brain Metastase... | Memantine -Twic... WBRT utilizing ... | 18 Years - | Medical College of Wisconsin | |
| Safety Study of Afatinib for Brain Cancer | NCT02423525 | Brain Cancer | Afatinib | 18 Years - | Saint John's Cancer Institute | |
| T-DXd Therapy for HER2-low Breast Cancer Patients With Brain Metastases | NCT06048718 | Breast Cancer Metastatic Brea... | Trastuzumab-Der... | 18 Years - | MedSIR | |
| A Single Arm Study of Neurocognitive Outcomes in Patients With Brain Metastases Managed With Stereotactic Radiosurgery (SRS) | NCT01821443 | Brain Metastase... | Stereotactic ra... | 18 Years - | University of California, San Francisco | |
| Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis After Radiosurgery for Brain Metastases | NCT02490878 | Radionecrosis Brain Metastase... | bevacizumab corticosteroids placebo | 18 Years - | Alliance for Clinical Trials in Oncology | |
| Hypofractionated Versus Single Fraction Stereotactic Adjuvant Radiotherapy to the Resection Cavity of Brain Metastases | NCT05160818 | Brain Metastase... Resection Cavit... | Hypofractionate... | 18 Years - | Technical University of Munich | |
| 18F ML-10 for Early Detection of Response of Brain Metastases to SRS | NCT00696943 | Metastasis to B... | ([18F]-ML-10) | 18 Years - | Aposense Ltd. | |
| Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases | NCT00838929 | Brain Metastase... | Vorinostat Radiation Thera... | 18 Years - | Thomas Jefferson University | |
| Nitroglycerin Plus Intracranial Radiotherapy for Brain Metastases in NSCLC Patients | NCT04338867 | Phase II Clinic... Ninety-six Hist... Randomized 1:1 ... ICPFS Evaluated... | Whole-brain rad... | 18 Years - 90 Years | Instituto Nacional de Cancerologia de Mexico | |
| A Trial Comparing Radiosurgery With Surgery for Solitary Brain Metastases | NCT00124761 | Neoplasm Metast... Brain Neoplasm | Surgery + WBRT Radiosurgery + ... | 18 Years - | Royal Adelaide Hospital | |
| Hippocampal-sparing Whole Brain Radiotherapy for Brain Metastases From Breast Cancer | NCT03002532 | Breast Cancer M... Brain Metastase... | whole brain rad... | 18 Years - 75 Years | Affiliated Hospital to Academy of Military Medical Sciences | |
| REMASTer: REcurrent Brain Metastases After SRS Trial | NCT05124912 | Brain Metastase... Radiation Necro... Recurrent Tumor Recurrent Metas... | Radiation Thera... Steroid Therapy Laser Interstit... | 18 Years - | Monteris Medical | |
| Pivotal, Open-label, Randomized Study of Radiosurgery With or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases From Non-small Cell Lung Cancer (NSCLC). | NCT02831959 | Brain Metastase... | NovoTTF-200M de... Best Standard o... | 18 Years - | NovoCure Ltd. | |
| Comparing Immobilisation Shells in Cranial Radiotherapy | NCT02599142 | Brain Metastase... Bone Metastases Brain Tumor, Pr... Brain Tumor Adu... Brain Tumor - M... | Group A: Closed... Group B: Open-f... | 18 Years - | Royal Marsden NHS Foundation Trust | |
| Short Course Radiation Therapy in Palliative Treatment of Brain Metastases | NCT03525301 | Brain Metastase... Radiotherapy Palliative Care | standard treatm... short course tr... | 18 Years - | IRCCS Azienda Ospedaliero-Universitaria di Bologna | |
| SH L 562BB Phase II/III Dose Justification and Gadoteridol-controlled Comparative Study | NCT00522951 | Brain Metastase... | Gadobutrol (Gad... Gadobutrol (Gad... ProHance | 20 Years - | Bayer | |
| E6201 Plus Dabrafenib for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS) | NCT03332589 | Malignant Melan... Brain Metastase... | E6201 E6201 plus dabr... | 18 Years - | Spirita Oncology, LLC | |
| Perfexion Brain Metastasis | NCT00805103 | Brain Metastase... | Hypofractionate... | 18 Years - | University Health Network, Toronto | |
| Dual Perfusion Imaging for Characterizing Vascular Architecture of Brain Lesions | NCT05358340 | Brain Tumor Brain Metastase... | Dynamic suscept... | 18 Years - | University Health Network, Toronto | |
| Open Label, Prospective Study to Investigate Efficacy and Safety of AZD9291 in BM From NSCLC Patients With EGFR T790M | NCT02972333 | EGFR-TKI Resist... Nonsmall Cell L... AZD9291 Brain Metastase... | AZD9291 80mg or... Radiation thera... | 18 Years - | Shandong Cancer Hospital and Institute | |
| Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S | NCT04430842 | Astrocytoma Brain Cancer Brain Metastase... Bladder Cancer Breast Cancer Cervical Cancer Cholangiocarcin... Colorectal Canc... Esophagus Cance... Gastric Cancer Head and Neck C... Kidney Cancer Liver Cancer Lung Cancer Melanoma Ovarian Cancer Pancreatic Canc... Pleural Mesothe... Prostate Cancer Sarcoma Tongue Cancer Thymic Carcinom... Urinary Tract C... | QBS10072S | 18 Years - | Quadriga Biosciences, Inc. | |
| Re-craniotomy and Complications After Elective Neurosurgery | NCT03910556 | Brain Tumor Brain Metastase... Brain Cancer Brain Neoplasms | Propofol | 18 Years - 75 Years | Chiang Mai University | |
| Intraoperative Radiotherapy After the Resection of Brain Metastases | NCT03226483 | Brain Metastase... | Intraoperative ... | 18 Years - | Universitätsmedizin Mannheim | |
| Fluorescence Guided Resection of Brain Tumors | NCT00870779 | Brain Tumors | 5-aminolevulini... | 21 Years - | Dartmouth-Hitchcock Medical Center | |
| Phase II Study of Gamma Knife Radiosurgery and Temozolomide for Brain Metastases | NCT00582075 | Cancer Brain Metastase... | temozolomide | 19 Years - | University of Alabama at Birmingham | |
| Stereotactic Radiotherapy Plus Temozolomide for Refractory Brain Metastases | NCT02654106 | Brain Metastase... | Fractionated St... Temozolomide | 18 Years - 75 Years | ChineseAMS | |
| Concurrent Dabrafenib + Trametinib With Sterotactic Radiation in BRAF Mutation-Positive Malignant Melanoma and Brain Metastases | NCT02974803 | Melanoma Brain Metastase... | Dabrafenib Trametinib | 18 Years - | Canadian Cancer Trials Group | |
| A Study of Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases | NCT03368625 | Brain Metastase... | Stereotactic Ra... | 18 Years - | University Health Network, Toronto | |
| A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis | NCT01173497 | Estrogen Recept... Progesterone Re... Human Epidermal... Brain Metastase... | INIPARIB + irin... | 21 Years - | Sanofi | |
| GRN1005 in Non-Small Cell Lung Cancer (NSCLC) Patients With Brain Metastases (GRABM-L) | NCT01497665 | Non-small Cell ... | GRN1005 | 18 Years - | Angiochem Inc | |
| Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study) | NCT03340129 | Melanoma Stage ... | Ipilimumab Nivolumab Stereotactic Ra... Salvage therapy | 18 Years - 120 Years | Melanoma Institute Australia | |
| A Study of Bevacizumab in Combination With First- or Second-Line Therapy in Subjects With Treated Brain Metastases Due to Non-Squamous NSCLC (PASSPORT) | NCT00312728 | Non-Small Cell ... Brain Neoplasms | bevacizumab First-Line Chem... Second-Line Che... | 18 Years - | Genentech, Inc. | |
| Dose-staged Gamma Knife Radiosurgery Versus Microsurgical Resection | NCT04857905 | Brain Metastase... | Microsurgical r... Gamma Knife rad... | 18 Years - 90 Years | Medical University of Vienna | |
| SRS Timing With Immune Checkpoint Inhibition in Patients With Untreated Brain Metastases From Non-small Cell Lung Cancer | NCT04650490 | Brain Metastase... Non Small Cell ... | Stereotactic Ra... Immunotherapy | 18 Years - | Duke University | |
| Electrochemotherapy as a Palliative Treatment for Brain Metastases | NCT01322100 | Brain Metastase... CNS Metastases | The Electropora... Bleomycin | 18 Years - | Copenhagen University Hospital at Herlev | |
| Tislelizumab Plus Chemotherapy as First-Line Treatment for Advanced Squamous NSCLC With Brain Metastases | NCT05207904 | Non-Small Cell ... Brain Metastase... | Tislelizumab, p... | 18 Years - 75 Years | Sun Yat-sen University | |
| High-dose Furmonertinib Versus Osimertinib in Advanced EGFRm NSCLC Patients With Brain Metastases | NCT06319950 | Lung Cancer, No... | Furmonertinib Osimertinib | 18 Years - 80 Years | Taizhou Hospital | |
| Icotinib Combined With WBRT For NSCLC Patients With Brain Metastases and EGFR Mutation | NCT01516983 | Non-small Cell ... Brain Metastase... | icotinib Whole brain rad... | 18 Years - 75 Years | Betta Pharmaceuticals Co., Ltd. | |
| Efficacy of metfOrmin in PrevenTIng Glucocorticoid-induced Diabetes in Patients With Brain Metastases | NCT04001725 | Brain Metastase... Melanoma Lung Cancer Breast Cancer | Dexamethasone Metformin | 18 Years - 75 Years | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | |
| Cognitive Outcome After Gamma Knife Radiosurgery in Patients With Brain Metastases (CAR-Study A) | NCT02953756 | Neoplasm Metast... | Gamma Knife rad... | 18 Years - | Elisabeth-TweeSteden Ziekenhuis | |
| Local Radiotherapy Following Complete Resection of a Brain Metastasis | NCT02729558 | Brain Neoplasms | local SRT | 18 Years - | Amsterdam UMC, location VUmc |
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