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Brief Title: In Vivo Confocal Endomicroscopy of the Brain
Official Title: In Vivo Confocal Endomicroscopy of the Brain
Study ID: NCT00949793
Brief Summary: The purpose of the study is to test the feasibility of obtaining interpretable in vivo endomicroscopy images which can be compared with traditional histopathology. Hypothesis: That a rigid confocal endomicroscope can be used during neurosurgery to provide in vivo histology that enables differentiation of tumour tissue from normal adjacent brain tissue.
Detailed Description: Confocal endomicroscopy is a medical imaging modality that allows real-time microscopy to be performed on living tissue in vivo. It is already in clinical use in the fields of gastroenterological endoscopy, laparoscopy, dermatology, gynecology and respiratory medicine. This study represents the first time that confocal endomicroscopy will be evaluated for intraoperative imaging in neurosurgery. The procedure involves a small endoscope which is placed gently into contact with the brain, providing significant in vivo magnification on a scale similar to that obtained by the pathology laboratory microscope. The captured confocal images will be compared with corresponding histology (tissue that is being removed as part of the indicated neurosurgical procedure). The images will be visually compared among each other and with histology images to detect possible clinically relevant information.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States
Name: Peter Nakaji, MD
Affiliation: Barrow Neurological Institute, St. Joseph's Hospital and Medical Center
Role: PRINCIPAL_INVESTIGATOR