Spots Global Cancer Trial Database for Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
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Trial Identification
Brief Title: Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
Official Title: An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements
Study ID: NCT02568267
Conditions
Interventions
Study Description
Brief Summary: This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene fusion. Patients will be assigned to different baskets according to tumor type and gene fusion.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Dignity Health St Joseph's Hospital and Medical Center, Phoenix, Arizona, United States
Mayo Clinic, Scottsdale, Arizona, United States
City of Hope Cancer Center; Division of Medical Oncology & Experimental Therapeutics, Duarte, California, United States
Scripps Clinic, La Jolla, California, United States
University of California San Diego Moores Cancer Center; Dept of Lung Cancer, La Jolla, California, United States
University of Southern California Medical Center, Los Angeles, California, United States
Univ Of California Irvine College Of Medicine; 300194620, Orange, California, United States
Southern California Kaiser Permanente, San Diego, California, United States
UCSF Mount Zion Medical Ctr, San Francisco, California, United States
Sarcoma Oncology Center, Santa Monica, California, United States
University of Colorado Cancer Center, Aurora, Colorado, United States
Yale University, New Haven, Connecticut, United States
Georgetown University Medical Center Lombardi Cancer Center, Washington, District of Columbia, United States
Florida Cancer Specialists - Sarasota, Sarasota, Florida, United States
H. Lee Moffitt Cancer Center and Research Inst., Tampa, Florida, United States
University Cancer & Blood Center, LLC; Research, Athens, Georgia, United States
Winship Cancer Institute, Atlanta, Georgia, United States
Southeastern Regional Medical Center, Inc., Newnan, Georgia, United States
Northwestern University, Chicago, Illinois, United States
Advocate Medical Group - Park Ridge, Luther Lane - Oncology, Park Ridge, Illinois, United States
Midwestern Regional Medical Center, Zion, Illinois, United States
Weinberg Cancer Institution at Franklin Square, Baltimore, Maryland, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
University of Michigan Comprehensive Cancer Center; Clinical Trials Office, Ann Arbor, Michigan, United States
Karmanos Cancer Center, Detroit, Michigan, United States
Henry Ford Hospital, Detroit, Michigan, United States
Regents of the University of Minnesota, Minneapolis, Minnesota, United States
Washington University, Saint Louis, Missouri, United States
Comprehensive Cancer Centers of Nevada (CCCN) - Central Valley, Las Vegas, Nevada, United States
North Shore Hem Onc Associates, East Setauket, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Levine Cancer Institute, Charlotte, North Carolina, United States
Duke Cancer Institute, Durham, North Carolina, United States
OSU, James Cancer Hospital, Columbus, Ohio, United States
Cancer Treatment Centers of America; Tulsa, Tulsa, Oklahoma, United States
Oregon Health & Science Univ, Portland, Oregon, United States
Cancer Treatment Centers of America - Eastern Regional Medical Center, Philadelphia, Pennsylvania, United States
Mary Crowley Medical Research Center, Dallas, Texas, United States
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Baylor Scott & White Health, Temple, Texas, United States
University of Utah Hospitals & Clinics, Salt Lake City, Utah, United States
Virginia Cancer Specialists, PC, Fairfax, Virginia, United States
Virginia Oncology Associates - Hampton, Hampton, Virginia, United States
University of Washington Seattle Cancer Care Alliance, Seattle, Washington, United States
Liverpool Hospital, Liverpool, New South Wales, Australia
Newcastle Private Hospital, New Lambton Heights, New South Wales, Australia
Flinders Medical Centre, Bedford Park, South Australia, Australia
Austin Health, Heidelberg, Victoria, Australia
Antwerp University Hospital, Edegem, , Belgium
Beijing Cancer Hospital, Beijing, , China
Sichuan Provincial Cancer Hospital, Chengdu, , China
Cancer Center of Guangzhou Medical University, Guangzhou, , China
Harbin Medical University Cancer Hospital, Harbin, , China
Fudan University Shanghai Cancer Center, Shanghai City, , China
Shanghai chest hospital, Shanghai, , China
Shenzhen People's Hospital, Shenzhen, , China
Tianjin Cancer Hospital, Tianjin, , China
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan City, , China
Zhejiang Cancer Hospital, Zhejiang, , China
Institut de Cancerologie de l Ouest, Angers, , France
Institut Bergonie; Oncologie, Bordeaux, , France
Centre Leon Berard; Departement Oncologie Medicale, Lyon, , France
Hôpital de la Timone; Oncologie Médicale Hématologie & Soins Palliatifs, Marseille cedex 5, , France
Hôpital Nord - AP-HM Marseille#; Service d'Oncologie Multidisciplinaire, Marseille, , France
Institut de Recherche en Cancérologie de Montpellier, Montpellier cedex 5, , France
Institut Curie; Oncologie Medicale, Paris, , France
Institut De Cancerologie De L'ouest - Rene Gauducheau - Biology, Saint Herblain, , France
Institut Claudius Regaud; Departement Oncologie Medicale, Toulouse, , France
Institut Gustave Roussy; Pathologie Thoracique, Villejuif cedex, , France
Evang. Lungenklinik Berlin Klinik für Pneumologie, Berlin, , Germany
Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden, , Germany
Universitaetsmedizin Goettingen; Abteilung Haematologie und Onkologie, Göttingen, , Germany
NCT Uniklinikum Heidelberg; Medizinische Onkologie, Heidelberg, , Germany
Universitaetsklinikum Koeln; Innere Medizin I, Haematologie, Köln, , Germany
Princess Margaret Hospital, Hong Kong, , Hong Kong
The University of Hong Kong, Hong Kong, , Hong Kong
Queen Elizabeth Hospital, Kowloon, , Hong Kong
The Chinese University of Hong Kong, Shatin, , Hong Kong
Seconda Università degli Studi di Napoli; Servizio Epato-Gastroenterologia, Napoli, Campania, Italy
Università Campus Bio-Medico di Roma; Oncologia Medica, Roma, Lazio, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Lombardia, Italy
Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda); Oncologico -Onc.Falck, Milano, Lombardia, Italy
Azienda Ospedaliero Universitaria Pisana; Uff. Sperim. Clin. U.O. Farmaceutica, Pisa, Toscana, Italy
Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia ; S.C. Oncologia Medica, Perugia, Umbria, Italy
IOV - Istituto Oncologico Veneto - IRCCS; Oncologia Medica II, Padova, Veneto, Italy
Aichi Cancer Center Hospital; Respiratory Medicine, Aichi, , Japan
NHO Shikoku Cancer Center; Dept of Respiratory Medicine, Ehime, , Japan
NHO Kyushu Cancer Center, Fukuoka, , Japan
Hyogo Cancer Center, Dept of Respiratory Medicine, Hyogo, , Japan
National Cancer Center Hospital; Dept of Respiratory Medicine, Kashiwa-shi, , Japan
Miyagi Cancer Center; Respiratory Medicine, Miyagi, , Japan
Niigata Cancer Center Hospital; Internal Medicine, Niigata, , Japan
OSAKA CITY GENERAL HOSPITAL;Medical Oncology, Osaka, , Japan
Kindai University Hospital; Medical Oncology, Osaka, , Japan
Shizuoka Cancer Center; Respiratory Internal Medicine, Shizuoka, , Japan
Seoul National University Hospital, Seoul, , Korea, Republic of
Severance Hospital, Yonsei University Health System, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Asan Medical Center., Seoul, , Korea, Republic of
NKI The Netherlands Cancer Institute, Amsterdam, , Netherlands
Leids Universitair Medisch Centrum, Leiden, , Netherlands
Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii, Gdansk, , Poland
Centrum Onkologii-Instytut im.M.Sklodowskiej Curie; Dept of Nuclear Med. and Endocrine Oncology, Gliwice, , Poland
Szpital Kliniczny Przemienienia Panskiego Uni. Medycznego im. Karola Marcinkowskiego; Chemotherapy, Pozna?, , Poland
Centrum Onkologii Instytut im. M. Sklodowskiej-Curie, Klinika Nowotworow Ukladu Chlonnego, Warszawa, , Poland
National University Hospital; Haematology/Oncology, Singapore, , Singapore
National Cancer Centre, Singapore, , Singapore
Centro Nacional de Investigaciones Oncológicas(CNIO); Gastrointestinal Cancer Clinical Research Unit, Fuenlabrada, Madrid, Spain
Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona, , Spain
Hospital Universitario Ramon y Cajal; Servicio de Farmacia, Madrid, , Spain
Hospital Universitario Clínico San Carlos; Servicio de Oncologia, Madrid, , Spain
Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid, , Spain
Hospital Universitario La Paz; Servicio de Oncologia, Madrid, , Spain
Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Malaga, , Spain
Hospital Universitario Virgen del Rocio; Servicio de Oncologia, Sevilla, , Spain
National Cheng Kung University Hospital, Tainan, , Taiwan
Taipei Veterans General Hospital, Taipei City, , Taiwan
National Taiwan University Hospital, Taipei, , Taiwan
Addenbrookes Hospital, Cambridge, , United Kingdom
Sarah Cannon Research Institute, London, , United Kingdom
Christie Hospital Nhs Trust; Medical Oncology, Manchester, , United Kingdom
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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