Spots Global Cancer Trial Database for Growth Factor Levels in the Blood of Patients Undergoing Radiation Therapy for Epithelial Cancer
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Trial Identification
Brief Title: Growth Factor Levels in the Blood of Patients Undergoing Radiation Therapy for Epithelial Cancer
Official Title: A Pilot Study of TGF-beta as a Potential Target for Prevention of Radiation-Induced Injury
Study ID: NCT00897793
Study Description
Brief Summary: RATIONALE: Measuring levels of transforming growth factor-beta (TGF-beta) in the blood of patients with epithelial cancers (head and neck, lung, breast, colorectal, and prostate) may help doctors predict how patients will respond to treatment with radiation therapy. PURPOSE: This research study is measuring levels of TGF-beta in patients with epithelial cancers who are undergoing radiation therapy.
Detailed Description: OBJECTIVES: * To determine whether there is a dose-dependent increase in TGF-beta following radiotherapy in patients with epithelial cancers. OUTLINE: Patients undergo blood sample collection prior to treatment, 24-72 hours after the first fraction of radiotherapy, and at the end of radiotherapy. Patients will also be asked for a weekly blood sample, but this is optional. Samples are analyzed to compare pre- and post-treatment TGF-beta levels.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Vanderbilt-Ingram Cancer Center - Cool Springs, Nashville, Tennessee, United States
Vanderbilt-Ingram Cancer Center at Franklin, Nashville, Tennessee, United States
Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States
Contact Details
Name: A. Bapsi Chakravarthy, MD
Affiliation: Vanderbilt-Ingram Cancer Center
Role: STUDY_CHAIR
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