Spots Global Cancer Trial Database for Anti-Tumor Immunity Induced by Cryoablation of Invasive Breast Cancers

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Trial Identification

Brief Title: Anti-Tumor Immunity Induced by Cryoablation of Invasive Breast Cancers

Official Title: CHUM-CRYOABLATION: Anti-Tumor Immunity Induced by Cryoablation of Invasive Breast Cancers

Study ID: NCT01856036

Conditions

Breast Cancer

Interventions

Cryoablation

Study Description

Brief Summary: This protocol will study the impact of cryoablation on immune response in patients diagnosed with invasive breast cancers smaller than 1.5 cm. It will profile the immune response to cryoablation of invasive breast cancers. The intra-tumoral and systemic immune response to cryoablation will be determined and compared to pre-ablated breast cancer specimens and historical control specimens.

Detailed Description: Patients with small breast cancers will undergo cryoablation of their breast cancer. Approximately six weeks after cryoablation, definitive breast surgery will be performed. Blood will be drawn for research before cryoablation and surgery and at regular follow-up visits. Blood and tissue samples will be used to determine immune responses.