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Spots Global Cancer Trial Database for Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer

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Trial Identification

Brief Title: Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer

Official Title: Study of Manual Nipple Fluid Aspiration IN Post-Menopausal Women

Study ID: NCT00291083

Conditions

Breast Cancer

Interventions

Study Description

Brief Summary: To examine nipple aspirate fluid for secretions that may be identified as a high risk indicator for development of breast cancer, and compare those to serum analysis.

Detailed Description: To examine nipple aspirate fluid analysis in lactating women for local concentration of estrogen, prolactin, glucocorticoids, insulin, parity, prior lactation and age. NAF secretors have been reported to have modest increase in breast cancer risk compared to non-secretors . Estrogen levels have been found to be markedly higher in NAF samples than in the serum collected from the same women. Estradiol and estrone concentrations in premenopausal women are 10x and 20x greater in NAF samples than in serum and 50x and 35x greater in post-menopausal women not on HRT. It has been suggested that the disparity between serum and NAF levels may be due to local estrogen production via aromatase and sulfatase.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: Yes

Locations

University of Kansas Medical Center, Kansas City, Kansas, United States

Contact Details

Name: Carol J Fabian, MD

Affiliation: University of Kansas Medical Center

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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