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Brief Title: Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer
Official Title: Study of Manual Nipple Fluid Aspiration IN Post-Menopausal Women
Study ID: NCT00291083
Brief Summary: To examine nipple aspirate fluid for secretions that may be identified as a high risk indicator for development of breast cancer, and compare those to serum analysis.
Detailed Description: To examine nipple aspirate fluid analysis in lactating women for local concentration of estrogen, prolactin, glucocorticoids, insulin, parity, prior lactation and age. NAF secretors have been reported to have modest increase in breast cancer risk compared to non-secretors . Estrogen levels have been found to be markedly higher in NAF samples than in the serum collected from the same women. Estradiol and estrone concentrations in premenopausal women are 10x and 20x greater in NAF samples than in serum and 50x and 35x greater in post-menopausal women not on HRT. It has been suggested that the disparity between serum and NAF levels may be due to local estrogen production via aromatase and sulfatase.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: Yes
University of Kansas Medical Center, Kansas City, Kansas, United States
Name: Carol J Fabian, MD
Affiliation: University of Kansas Medical Center
Role: PRINCIPAL_INVESTIGATOR