Spots Global Cancer Trial Database for chemoprevention
Every month we try and update this database with for chemoprevention cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Pioglitazone for Lung Cancer Chemoprevention | NCT00780234 | Lung Cancer Endobronchial D... | fluorescence br... quantitative hi... PIOGLITAZONE VS... | 18 Years - | VA Office of Research and Development | |
| Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis | NCT00808743 | Familial Adenom... Duodenal Neopla... Duodenal Polyps | Celecoxib Ursodeoxycholic... Placebo | 18 Years - 70 Years | Radboud University Medical Center | |
| Metformin for the Prevention of CRA Recurrence | NCT04885426 | Colorectal Aden... Metformin Chemoprevention | low-dose metfor... high-dose metfo... Placebo | 40 Years - 80 Years | Shanghai Jiao Tong University School of Medicine | |
| A Pilot Trial of Tamoxifen and 4-HPR (4-N-Hydroxyphenyl Retinamide) in Persons at High Risk for Developing Breast Cancer | NCT00001378 | Breast Cancer Breast Neoplasm... | fenretinide | - | National Institutes of Health Clinical Center (CC) | |
| Black Raspberry Confection in Preventing Oral Cancer in Healthy Volunteers | NCT01961869 | Healthy Volunte... | Fast release BR... Intermed releas... Prolong release... | 18 Years - 65 Years | Ohio State University Comprehensive Cancer Center | |
| Antioxidant Supplement and Reduction of Metachronous Adenomas of the Large Bowel: a Double Blind Randomized Trial | NCT01437826 | Colorectal Aden... | antioxidants placebo | 25 Years - 75 Years | IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy | |
| Selenium and Prostate Cancer: Clinical Trial on Availability to Prostate Tissue and Effects on Gene Expression | NCT00446901 | Prostatic Neopl... Prostate Cancer | Selenium | - | Wageningen University | |
| Phase I-II Multiple-Dose Safety and Efficacy Study of a Selective Inhibitor of Cyclooxygenase - 2 (SC-58635) in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients and Carriers | NCT00001693 | Colorectal Neop... Hereditary Nonp... | Celecoxib (SC-5... | - | National Institutes of Health Clinical Center (CC) | |
| Erlotinib for Chemoprevention in Trisomy 7 Positive Primary Sclerosing Cholangitis (PSC) | NCT00955149 | Primary Scleros... Trisomy 7 Cholangiocarcin... Chemoprevention | Erlotinib (Tarc... | 18 Years - | Mayo Clinic | |
| Mesalazine Effects in Sporadic Colorectal Adenoma Patients | NCT01894685 | Sporadic Colore... | Mesalazine Placebo | 50 Years - 75 Years | UMC Utrecht | |
| Clinical Trial of Lung Cancer Chemoprevention With Sulforaphane in Former Smokers | NCT03232138 | Lung Cancer | Sulforaphane Placebo | 55 Years - 75 Years | University of Pittsburgh | |
| Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCR | NCT00001698 | Leukoplakia Periodontal Dis... | Ketorolac Rinse | - | National Institutes of Health Clinical Center (CC) | |
| Black Raspberry Confection in Preventing Oral Cancer in Healthy Volunteers | NCT01961869 | Healthy Volunte... | Fast release BR... Intermed releas... Prolong release... | 18 Years - 65 Years | Ohio State University Comprehensive Cancer Center | |
| A Phase IIb Trial of Pulmicort Turbuhaler (Budesonide) | NCT00175747 | Lung Cancer | Inhaled Budeson... | 40 Years - | University of British Columbia | |
| A Randomized, 2x2 Factorial Design Biomarker Prevention Trial of Low-dose ASA and Metformin in Stage I-III Crc Patients | NCT03047837 | Tertiary Preven... | ASA MET Placebo | 18 Years - 80 Years | Ente Ospedaliero Ospedali Galliera | |
| Prevention of Breast Cancer: As Simple as hCG-A Randomized Clinical Trial in High Risk Women | NCT00808522 | Breast Cancer | hCG | 30 Years - 75 Years | New York Presbyterian Hospital | |
| Phase II Trial to Modulate Intermediate Endpoint Biomarkers in Former and Current Smokers | NCT03598309 | Lung Diseases Lung Cancer, Pr... | Curcumin C3 com... Lovaza® Placebo | 55 Years - | H. Lee Moffitt Cancer Center and Research Institute | |
| Curcumin for the Chemoprevention of Colorectal Cancer | NCT00118989 | Adenomatous Pol... | Curcuminoids | 18 Years - | University of Pennsylvania | |
| Risk Factors, Prognosis, and Potential Chemoprevention Drugs in Patients With Recurrent Hepatocellular Carcinoma After Curative Surgeries: a Nationwide Retrospective Cohort Study and a Multi-center Prospective Cohort Analysis | NCT05990959 | Hepatocellular ... Surgery | No intervention... | 20 Years - | China Medical University Hospital | |
| Pre-Prostatectomy Celecoxib or Placebo | NCT02840162 | Adenocarcinoma ... Prostate Cancer | Celecoxib Placebo | 18 Years - | OHSU Knight Cancer Institute | |
| Prostate Cancer Prevention Study for Men With High Grade PIN (Prostatic Intraepithelial Neoplasia) | NCT00106691 | Preneoplastic C... Prostatic Intra... | Toremifene 20 m... Placebo | 30 Years - | GTx | |
| Study of Web-based Decision Aids for Increasing Breast Cancer Chemoprevention in the Primary Care Setting | NCT03069742 | Breast Neoplasm | RealRisks BNAV | 35 Years - 75 Years | Columbia University | |
| Phase 1b Food Based Modulation of Biomarkers in Human Tissues at High-Risk for Oral Cancer. | NCT01469429 | Metastatic Squa... Salivary Gland ... Stage 0 Hypopha... Stage 0 Larynge... Stage 0 Lip and... Stage 0 Nasopha... Stage 0 Orophar... Stage 0 Paranas... Stage I Salivar... Stage I Squamou... Stage I Squamou... Stage I Squamou... Stage I Squamou... Stage I Squamou... Stage I Squamou... Stage I Verruco... Stage I Verruco... Stage II Saliva... Stage II Squamo... Stage II Squamo... Stage II Squamo... Stage II Squamo... Stage II Squamo... Stage II Squamo... Stage II Verruc... Stage II Verruc... Stage III Saliv... Stage III Squam... Stage III Squam... Stage III Squam... Stage III Squam... Stage III Squam... Stage III Verru... Stage III Verru... Stage IV Squamo... Stage IV Squamo... Stage IVA Saliv... Stage IVA Squam... Stage IVA Oral ... Stage IVA Squam... Stage IVA Nasal... Stage IVA Verru... Stage IVA Verru... Stage IVB Saliv... Stage IVB Squam... Stage IVB Squam... Stage IVB Squam... Stage IVB Oral ... Stage IVB Verru... Stage IVB Verru... Stage IVC Saliv... Stage IVC Squam... Stage IVC Oral ... Stage IVC Squam... Paranasal Sinus... Stage IVC Verru... Stage IVC Verru... Tongue Cancer | placebo laboratory biom... questionnaire a... chemoprevention chemoprevention placebo | 21 Years - | Ohio State University Comprehensive Cancer Center | |
| Phase I-II Multiple-Dose Safety and Efficacy Study of a Selective Inhibitor of Cyclooxygenase - 2 (SC-58635) in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients and Carriers | NCT00001693 | Colorectal Neop... Hereditary Nonp... | Celecoxib (SC-5... | - | National Institutes of Health Clinical Center (CC) | |
| Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis | NCT00808743 | Familial Adenom... Duodenal Neopla... Duodenal Polyps | Celecoxib Ursodeoxycholic... Placebo | 18 Years - 70 Years | Radboud University Medical Center | |
| Erlotinib for Hepatocellular Carcinoma Chemoprevention | NCT04172779 | Cirrhosis, Live... | Erlotinib Hydro... | 18 Years - | University of Texas Southwestern Medical Center | |
| Pioglitazone for Lung Cancer Chemoprevention | NCT00780234 | Lung Cancer Endobronchial D... | fluorescence br... quantitative hi... PIOGLITAZONE VS... | 18 Years - | VA Office of Research and Development | |
| Clinical Validity and Utility of Genomic-targeted Chemoprevention of PCa: Aim 4a | NCT02381015 | Prostate Cancer Prostate Cancer... Hereditary Pros... | Genetic Risk Sc... Genetic Risk Sc... Family History:... Family History:... | 40 Years - 49 Years | NorthShore University HealthSystem | |
| What Are the Benefits and Harms of Risk Stratified Screening in the NHS Breast Screening Programme: Study Protocol | NCT04359420 | Breast Cancer | BC-Predict NHS Breast Scre... | - | University of Manchester | |
| Black Raspberry Confection in Preventing Oral Cancer in Healthy Volunteers | NCT01961869 | Healthy Volunte... | Fast release BR... Intermed releas... Prolong release... | 18 Years - 65 Years | Ohio State University Comprehensive Cancer Center | |
| Primary Prevention Hepatocellular Carcinoma by Metformin | NCT02319200 | Hepatocellular ... Hepatitis C, Ch... Cirrhosis | Metformin placebo tablet | 18 Years - 77 Years | Assistance Publique - Hôpitaux de Paris | |
| Protocol for Women at Increased Risk of Developing Breast Cancer | NCT00291694 | Breast Cancer | celecoxib placebo | 18 Years - | University of Kansas Medical Center | |
| EGCG for Hepatocellular Carcinoma Chemoprevention | NCT06015022 | Cirrhosis, Live... | Epigallocatechi... Placebo | 18 Years - | University of Texas Southwestern Medical Center | |
| Risk Factors, Prognosis, and Potential Chemoprevention Drugs in Patients With Recurrent Hepatocellular Carcinoma After Curative Surgeries: a Nationwide Retrospective Cohort Study and a Multi-center Prospective Cohort Analysis | NCT05990959 | Hepatocellular ... Surgery | No intervention... | 20 Years - | China Medical University Hospital | |
| Protocol for Women at Increased Risk of Developing Breast Cancer | NCT00291135 | Breast Cancer | letrozole | 18 Years - | University of Kansas Medical Center | |
| Niclosamide for Familial Adenomatous Polyposis | NCT04296851 | Familial Adenom... | Niclosamide placebo | 20 Years - 65 Years | Yonsei University | |
| Synthetic Genistein (BONISTEIN™) in Patients Who Are Undergoing Surgery for Prostate Cancer | NCT00546039 | Prostatic Neopl... | Genistein Placebo | 18 Years - | University Hospital, Aker | |
| Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer | NCT00291083 | Breast Cancer | 18 Years - | University of Kansas Medical Center | ||
| Prostate Cancer Prevention Study for Men With High Grade PIN (Prostatic Intraepithelial Neoplasia) | NCT00106691 | Preneoplastic C... Prostatic Intra... | Toremifene 20 m... Placebo | 30 Years - | GTx | |
| Chemoprevention of Head and Neck Squamous Cell Carcinoma (HNSCC) With Valproic Acid | NCT02608736 | Head and Neck S... | Valproic Acid Placebo | 18 Years - | Barretos Cancer Hospital | |
| Selenium and Vitamin E in Preventing Cancer Progression and Recurrence in Patients With Early-Stage Bladder Cancer | NCT00553345 | Bladder Cancer | selenium vitamin E chemoprevention | 18 Years - | National Cancer Institute (NCI) | |
| Prevention of Breast Cancer: As Simple as hCG-A Randomized Clinical Trial in High Risk Women | NCT00808522 | Breast Cancer | hCG | 30 Years - 75 Years | New York Presbyterian Hospital | |
| Modulation of Breast Cancer Risk Biomarkers by High Dose Vitamin D | NCT01166763 | Breast Cancer | vitamin D3 | - 55 Years | University of Kansas Medical Center | |
| Phase 1b Food Based Modulation of Biomarkers in Human Tissues at High-Risk for Oral Cancer. | NCT01469429 | Metastatic Squa... Salivary Gland ... Stage 0 Hypopha... Stage 0 Larynge... Stage 0 Lip and... Stage 0 Nasopha... Stage 0 Orophar... Stage 0 Paranas... Stage I Salivar... Stage I Squamou... Stage I Squamou... Stage I Squamou... Stage I Squamou... Stage I Squamou... Stage I Squamou... Stage I Verruco... Stage I Verruco... Stage II Saliva... Stage II Squamo... Stage II Squamo... Stage II Squamo... Stage II Squamo... Stage II Squamo... Stage II Squamo... Stage II Verruc... Stage II Verruc... Stage III Saliv... Stage III Squam... Stage III Squam... Stage III Squam... Stage III Squam... Stage III Squam... Stage III Verru... Stage III Verru... Stage IV Squamo... Stage IV Squamo... Stage IVA Saliv... Stage IVA Squam... Stage IVA Oral ... Stage IVA Squam... Stage IVA Nasal... Stage IVA Verru... Stage IVA Verru... Stage IVB Saliv... Stage IVB Squam... Stage IVB Squam... Stage IVB Squam... Stage IVB Oral ... Stage IVB Verru... Stage IVB Verru... Stage IVC Saliv... Stage IVC Squam... Stage IVC Oral ... Stage IVC Squam... Paranasal Sinus... Stage IVC Verru... Stage IVC Verru... Tongue Cancer | placebo laboratory biom... questionnaire a... chemoprevention chemoprevention placebo | 21 Years - | Ohio State University Comprehensive Cancer Center | |
| Metformin for the Prevention of CRA Recurrence | NCT04885426 | Colorectal Aden... Metformin Chemoprevention | low-dose metfor... high-dose metfo... Placebo | 40 Years - 80 Years | Shanghai Jiao Tong University School of Medicine | |
| Genetic Counseling for Menopausal Therapy Decision-Making for Women at Increased Risk for Breast Cancer | NCT00349011 | Menopause | Personalized ri... genetic counsel... | 40 Years - | Yale University | |
| RANKL Inhibition and Breast Tissue Biomarkers | NCT03629717 | Breast Cancer P... Mammographic De... | Ultrasound-guid... Denosumab Blood draw Calcium Vitamin D | 35 Years - | Washington University School of Medicine | |
| Prospective Trial of Metformin - Chemoprevention Role | NCT01550900 | Colorectum | Metformin ER Placebo | 40 Years - 75 Years | M.D. Anderson Cancer Center | |
| Erlotinib for Chemoprevention in Trisomy 7 Positive Primary Sclerosing Cholangitis (PSC) | NCT00955149 | Primary Scleros... Trisomy 7 Cholangiocarcin... Chemoprevention | Erlotinib (Tarc... | 18 Years - | Mayo Clinic | |
| Clinical Trial of Lung Cancer Chemoprevention With Sulforaphane in Former Smokers | NCT03232138 | Lung Cancer | Sulforaphane Placebo | 55 Years - 75 Years | University of Pittsburgh | |
| Chemoprevention of Head and Neck Squamous Cell Carcinoma (HNSCC) With Valproic Acid | NCT02608736 | Head and Neck S... | Valproic Acid Placebo | 18 Years - | Barretos Cancer Hospital | |
| Selenium and Prostate Cancer: Clinical Trial on Availability to Prostate Tissue and Effects on Gene Expression | NCT00446901 | Prostatic Neopl... Prostate Cancer | Selenium | - | Wageningen University | |
| Trial on Safety and Pharmacokinetics of Intravaginal Curcumin | NCT01035580 | Uterine Cervica... | Curcumin curcumin | 18 Years - 45 Years | Emory University | |
| Selenium and Prostate Cancer: Clinical Trial on Availability to Prostate Tissue and Effects on Gene Expression | NCT00446901 | Prostatic Neopl... Prostate Cancer | Selenium | - | Wageningen University | |
| Aquamin and Prevention of Colon Cancer | NCT02647671 | Colonic Cancer | Aquamin® Calcium Carbona... Placebo | 18 Years - 80 Years | University of Michigan | |
| Basal Cell Carcinoma Chemoprevention Trial | NCT05212246 | Basal Cell Carc... | 5% Imiquimod cr... Placebo Vehicle... | 18 Years - | VA Office of Research and Development | |
| Exemestane and Celecoxib in Postmenopausal Women at High Risk for Breast Cancer | NCT00073073 | Breast Neoplasm... | Exemestane Calcium carbona... Vitamin D | - | Georgetown University | |
| Trial on Safety and Pharmacokinetics of Intravaginal Curcumin | NCT01035580 | Uterine Cervica... | Curcumin curcumin | 18 Years - 45 Years | Emory University | |
| Protocol for Women at Increased Risk of Developing Breast Cancer | NCT00291135 | Breast Cancer | letrozole | 18 Years - | University of Kansas Medical Center | |
| Synthetic Genistein (BONISTEIN™) in Patients Who Are Undergoing Surgery for Prostate Cancer | NCT00546039 | Prostatic Neopl... | Genistein Placebo | 18 Years - | University Hospital, Aker | |
| Know Your Risk: Assessment at Screening for Breast Cancer - Pilot Study | NCT02954900 | Breast Neoplasm... | RealRisks BNAV | 35 Years - 75 Years | Columbia University | |
| RANKL Inhibition and Breast Tissue Biomarkers | NCT03629717 | Breast Cancer P... Mammographic De... | Ultrasound-guid... Denosumab Blood draw Calcium Vitamin D | 35 Years - | Washington University School of Medicine | |
| Curcumin for the Chemoprevention of Colorectal Cancer | NCT00118989 | Adenomatous Pol... | Curcuminoids | 18 Years - | University of Pennsylvania | |
| Clinical Trial of Lung Cancer Chemoprevention With Sulforaphane in Former Smokers | NCT03232138 | Lung Cancer | Sulforaphane Placebo | 55 Years - 75 Years | University of Pittsburgh | |
| Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome | NCT03070574 | Colorectal Canc... | mesalamine 2400... mesalamine 1200... Placebo | 25 Years - | Medical University of Vienna | |
| Pre-Prostatectomy Celecoxib or Placebo | NCT02840162 | Adenocarcinoma ... Prostate Cancer | Celecoxib Placebo | 18 Years - | OHSU Knight Cancer Institute | |
| Different Factors Affecting Patients With Newly Diagnosed Bladder Cancer | NCT00553124 | Bladder Cancer | selenium vitamin E biopsy chemoprevention cryopreservatio... cytology specim... diagnostic proc... gene expression... immunohistochem... laboratory biom... medical chart r... mutation analys... polymerase chai... quality-of-life... questionnaire a... study of socioe... | 18 Years - | National Cancer Institute (NCI) | |
| Characterization of the Pharmacokinetics of Oral Selenium Compounds in Humans Before and Following Supplementation | NCT00342966 | Cancer | 20 Years - 60 Years | National Institutes of Health Clinical Center (CC) |
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