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Brief Title: Dissecting the Pathways of Therapy Resistance in Early Breast Cancer
Official Title: Dissecting the Pathways of Therapy Resistance in Early Breast Cancer: A Sub-study of the EORTC 10041/BIG 3-04 MINDACT Study
Study ID: NCT04995575
Brief Summary: Within the 1st step MINDACT patients who have already relapsed will be asked to participate. For these patients a biopsy of the metastasis should have been taken. A molecular analysis of the stored primary tumor sample and of the metastatic sample, using new technologies, will be performed, and the characteristics of both samples will be compared. Within the 2nd step a prospective collection of the metastasis samples will be implemented and analysis of biological material from relapsing MINDACT patients is foreseen. This process will provide insights on the biology of breast cancer and allow us to better understand mechanisms of resistance to therapies, contributing to overcoming this important problem.
Detailed Description:
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Onze Lieve Vrouw Ziekenhuis, Aalst, , Belgium
Institut Jules Bordet-Hopital Universitaire ULB, Brussels, , Belgium
Hopital De Jolimont, Haine-Saint-Paul, , Belgium
CHU-UCL Namur - CHU Site Sainte-Elisabeth-UCL Namur, Namur, , Belgium
Ziekenhuisgroep Twente - Twenteborg Ziekenhuis (3), Almelo, , Netherlands