Spots Global Cancer Trial Database for Investigating the Biological Effects of the Addition of Zoledronic Acid to Pre-operative Chemotherapy in Breast Cancer
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Trial Identification
Brief Title: Investigating the Biological Effects of the Addition of Zoledronic Acid to Pre-operative Chemotherapy in Breast Cancer
Official Title: A Randomised Phase II Feasibility Study Investigating the Biological Effects of the Addition of Zoledronic Acid to Neoadjuvant Combination Chemotherapy on Invasive Breast Cancer
Study ID: NCT00525759
Conditions
Study Description
Brief Summary: There is clear preclinical in vitro and in vivo evidence of sequence dependent synergy between chemotherapy agents and zoledronic acid. The aim of the study is to investigate if the synergistic increase in tumour cell apoptosis observed in preclinical studies occurs in patients. The hypothesis for this study is that there may be anti-tumour benefits of the sequential application of chemotherapy agents followed by zoledronic acid in patients with invasive breast cancer.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Sheffield Teaching Hospitals NHS Foundation Trust / Weston Park Hospital, Sheffield, South Yorkshire, United Kingdom
Contact Details
Name: Robert E Coleman, MB BS, MD
Affiliation: Academic Unit of Clinical Oncology, University of Sheffield
Role: PRINCIPAL_INVESTIGATOR
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