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Spots Global Cancer Trial Database for Protocol for Women at Increased Risk of Developing Breast Cancer

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Protocol for Women at Increased Risk of Developing Breast Cancer

Official Title: Study of the Effect of Letrozole on Breast Biomarkers of High Risk Postmenopausal Women Receiving Hormone Replacement Therapy

Study ID: NCT00291135

Conditions

Breast Cancer

Interventions

letrozole

Study Description

Brief Summary: A pilot study to assess the effects of six months of letrozole on breast tissue risk markers in postmenopausal women on hormone replacement therapy at high risk of developing breast cancer.

Detailed Description: A pilot study of letrozole in postmenopausal women on hormone replacement therapy at high risk of developing breast cancer. Subjects will have hyperplasia with atypia (or borderline Epithelial Hyperplasia/Atypical Hyperplasia) and evidence of Estrogen Receptor expression by random periareolar fine needle aspiration and baseline serum estradiol levels less than or equal to 150 pg/ml. The feasibility of performing RT-qPCR on breast specimens for aromatase expression will also be done at baseline.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

University of Kansas Medical Center, Kansas City, Kansas, United States

Contact Details

Name: Carol J Fabian, MD

Affiliation: University of Kansas Medical Center

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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