Spots Global Cancer Trial Database for Study of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to HR+/HER2- Breast Cancer
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Trial Identification
Brief Title: Study of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to HR+/HER2- Breast Cancer
Official Title: An Open-label Multicenter Phase 1b-2 Study of Elacestrant in Combination With Abemaciclib in Women and Men With Brain Metastasis From Estrogen Receptor Positive, HER-2 Negative Breast Cancer
Study ID: NCT05386108
Study Description
Brief Summary: This is a multi-site, global, open-label study that includes a phase 1b evaluation of elacestrant in combination with abemaciclib in women and men with with or without brain metastases from ER-positive, HER-2 negative breast cancer. Phase 1b is designed to select the recommended phase 2 dose and will be followed by a phase 2 evaluation of elacestrant in combination with abemaciclib in patients with active brain metastases from ER-positive, HER-2 negative breast cancer.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Providence Medical Foundation, Fullerton, California, United States
California Research Institute, Los Angeles, California, United States
Carle Cancer Center, Urbana, Illinois, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Gabrail Cancer Center, Canton, Ohio, United States
SCRI Oncology Partners, Nashville, Tennessee, United States
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Virginia Cancer Institute, Norfolk, Virginia, United States
Antwerp University Hospital, Edegem, , Belgium
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg, Leuven, , Belgium
Universite Catholique de Louvain (UCL) - Cliniques Universitaires Saint-Luc, Woluwe-Saint-Lambert, , Belgium
Hôpital Morvan - CHRU de Brest - cancérologie et d'hématologie, Brest, , France
Centre de Cancerologie du Grand Montpellier, Montpellier, , France
Hopital de la Pitie Salpetriere, Paris, , France
Centre Hospitalier Universitaire de Poitiers, Poitiers, , France
Clinic Worms gGmbH, Worms, Rhineland-Palatinate, Germany
Klinikum Bayreuth GmbH, Bayreuth, , Germany
Universitaetsklinikum Duesseldorf, Düsseldorf, , Germany
Universitätsklinikum Erlangen, Erlangen, , Germany
Clinic Worms gGmbH, Worms, , Germany
Helios Klinikum Wuppertal, Wuppertal, , Germany
National and Capodistrian University of Athens - University General Hospital Attikon, Athens, , Greece
Metropolitan Hospital [Oncology], Piraeus, , Greece
EUROMEDICA General Clinic of Thessaloniki, Thessaloníki, , Greece
Interbalkan European Medical Center, Thessaloníki, , Greece
AOU Ospedali Riuniti Umberto I-G.M.Lancisi -G.Salesi, Ancona, , Italy
IEO - Istituto Europeo di Oncologia, IRCCS, Milano, , Italy
Ospedale San Gerardo, ASST di Monza, IRCCS, Monza, , Italy
PU A. Gemelli, Università Cattolica del Sacro Cuore, Rome, , Italy
Asan Medical Center, Seoul, , Korea, Republic of
Gangnam Severance Hospital, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Ewha Womans University MokDong Hospital, Seoul, , Korea, Republic of
Seoul National University Bundang Hospital, Seoul, , Korea, Republic of
University Hospital Reina Sofia, Córdoba, Andalusia, Spain
University Hospital Ramon y Cajal, Madrid, Community Of Madrid, Spain
University Hospital 12 de Octubre, Madrid, Community Of Madrid, Spain
Clara Campal Comprehensive Cancer Center (CIOCC), Madrid, Community Of Madrid, Spain
University Clinical Hospital Virgen de la Arrixaca, El Palmar, Murcia, Spain
Hospital Clínico San Carlos, Madrid, , Spain
Travesia da Choupana, Santiago De Compostela, , Spain
Hacettepe University Medical Faculty, Ankara, , Turkey
Memorial Ankara Hastanesi Tibbi Onkoloji, Ankara, , Turkey
Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul, , Turkey
The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, , United Kingdom
University College London Hospitals NHS Foundation Trust - University College Hospital (UCH) - Macmillan Cancer Centre, London, , United Kingdom
The Christie NHS Foundation Trust - Medical Oncology, Manchester, , United Kingdom
Contact Details
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