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Brief Title: Gene Expression Profile of Breast Cancer Samples After Vitamin D Supplementation
Official Title: Influence of Vitamin D on Gene Expression Profile of Breast Cancer Samples From Post-menopausal Patients
Study ID: NCT00926315
Brief Summary: The purpose of this study is to evaluate whether calcitriol supplementation may reduce tumor cell proliferation and influence gene expression profile of breast cancer samples from post-menopausal patients.
Detailed Description: Women affected by breast cancer present lower 1,25(OH)2D3 or 25(OH)D3 serum levels than unaffected ones. Calcitriol supplementation may be indicated to post-menopausal women to reduce bone loss. Vitamin D has antiproliferative effects in breast cancer cell lines and breast cancer xenografts. Post-menopausal breast cancer patients will be prescribed calcitriol supplementation, in doses indicated to prevent osteoporosis, while they are submitted to biopsy, staging exams and have their breast surgery scheduled (approximately one month). Tumor dimension and proliferation rate (as determined by Ki67 expression), 25(OH)D3 and/or 1,25(OH)2D3 serum concentration, will be evaluated before and after calcitriol supplementation. Tumor gene expression will be evaluated in samples collected before and after supplementation to analyze the differential profile.
Minimum Age: 40 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Instituto Brasileiro de Controle do Câncer - IBCC, São Paulo, SP, Brazil
Name: Maria Aparecida A Koike Folgueira, MD,PhD
Affiliation: Faculdade de Medicina - Universidade de São Paulo
Role: STUDY_CHAIR
Name: Eduardo Carneiro de Lyra, MD, PhD
Affiliation: Instituto Brasileiro de Controle do Cancer
Role: PRINCIPAL_INVESTIGATOR
Name: Yuri N Urata, MSc
Affiliation: Faculdade de Medicina da Universidade de São Paulo
Role: PRINCIPAL_INVESTIGATOR
Name: Maria Lucia H Katayama, PhD
Affiliation: Faculdade de Medicina da Universidade de São Paulo
Role: PRINCIPAL_INVESTIGATOR