Neoplasms

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Breast Neoplasms

Breast Diseases

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Bone Density Conservation Agents

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Vitamins

Vitamin D

Cholecalciferol

Calcitriol

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Calcium, Dietary

Trace Elements

Vitamin D3

Calciferol

calcitriol supplementation (0.25 mcg 2x/d)

Post menopausal patients will receive Calcitriol 0.50 mcg PO per day for 1 month.

calcitriol

Maria Aparecida A Koike Folgueira, MD,PhD

Eduardo Carneiro de Lyra, MD, PhD

Yuri N Urata, MSc

Maria Lucia H Katayama, PhD

The purpose of this study is to evaluate whether calcitriol supplementation may reduce tumor cell proliferation and influence gene expression profile of breast cancer samples from post-menopausal patients.

Women affected by breast cancer present lower 1,25(OH)2D3 or 25(OH)D3 serum levels than unaffected ones. Calcitriol supplementation may be indicated to post-menopausal women to reduce bone loss. Vitamin D has antiproliferative effects in breast cancer cell lines and breast cancer xenografts.

Post-menopausal breast cancer patients will be prescribed calcitriol supplementation, in doses indicated to prevent osteoporosis, while they are submitted to biopsy, staging exams and have their breast surgery scheduled (approximately one month). Tumor dimension and proliferation rate (as determined by Ki67 expression), 25(OH)D3 and/or 1,25(OH)2D3 serum concentration, will be evaluated before and after calcitriol supplementation. Tumor gene expression will be evaluated in samples collected before and after supplementation to analyze the differential profile.

Gene Expression Profile of Breast Cancer Samples After Vitamin D Supplementation

Influence of Vitamin D on Gene Expression Profile of Breast Cancer Samples From Post-menopausal Patients

Instituto Brasileiro de Controle do Cancer

University of Sao Paulo General Hospital

MD, PhD

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Gene Expression Profile of Breast Cancer Samples After Vitamin D Supplementation	NCT00926315	Breast Neoplasm... Postmenopausal ...	calcitriol Calcitriol	40 Years - 70 Years	University of Sao Paulo General Hospital
Gene Expression Profile of Breast Cancer Samples After Vitamin D Supplementation	NCT00926315	Breast Neoplasm... Postmenopausal ...	calcitriol Calcitriol	40 Years - 70 Years	University of Sao Paulo General Hospital

Spots Global Cancer Trial Database for postmenopausal disorder