Spots Global Cancer Trial Database for Development of a Non-invasive Assessment of Skeletal Muscle Loss in Cancer Patients
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Trial Identification
Brief Title: Development of a Non-invasive Assessment of Skeletal Muscle Loss in Cancer Patients
Official Title: Development of a Non-invasive Assessment of Skeletal Muscle Loss in Cancer Patients
Study ID: NCT00994669
Conditions
Interventions
Study Description
Brief Summary: The long-term objective of this research is to develop a non-invasive approach for early assessment of which patients are at high risk for future development of skeletal muscle atrophy. The investigators hypothesize that the rate constant for the terminal portion of the isotope decay curve following ingestion of a single oral dose of deuterated-3-methylhistidine (D-3MH) provides an accurate measure of this increased risk and that this rate constant can be measured non-invasively from timed spot urine samples. In addition, the investigators hypothesize that ingestion of a meat-containing meal will stimulate synthesis of skeletal muscle proteins to a greater extent than a non-meat-containing meal.
Detailed Description:
Keywords
Eligibility
Minimum Age: 30 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: Yes
Locations
University of Texas Medical Branch, Galveston, Texas, United States
Contact Details
Name: Melinda Sheffield-Moore, Ph.D.
Affiliation: University of Texas
Role: PRINCIPAL_INVESTIGATOR
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