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Spots Global Cancer Trial Database for 35kDa Hyaluronan Fragment Treatment of Colorectal and Rectal Cancer

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Trial Identification

Brief Title: 35kDa Hyaluronan Fragment Treatment of Colorectal and Rectal Cancer

Official Title: Injection of 35kDa Hyaluronan Fragment Alleviates Pain Associated With Radiotherapy for Treatment of Colorectal and Rectal Cancer

Study ID: NCT06209970

Conditions

Cancer Pain

Interventions

HA35

Study Description

Brief Summary: HA35 (Bioactive HA or B-HA or HA35) have good tissue permeability (B-HA injection, Ministry of Health, Registration number L20200708MP07707). HA35 might not lose HA's bioactivities of binding to a variety of hyaluronan's binding proteins or receptors, including the analgesic and anticancer effects of hyaluronan, therefore being named bioactive HA or B-HA (10) (B-HA injection, Ministry of Health, Registration number L20200708MP07707).

Detailed Description: The previous study has shown that naked mole rat who has high tissue content of hyaluronan and its fragments is insensitive to pain. The previous study has also shown that hyaluronan modulates pain-regulated TRPV1 channel opening, reducing peripheral nociceptor activity and pain. The previous study has again shown that local injection of 35kDa hyaluronan fragment HA35 is effective in treating inflammatory and neuropathic pain. This study employs freshly made HA35 injection for treatment of pain associated with radiotherapy for treatment of colorectal and rectal cancer. A numerical rating scale from 0 to 10 was used to assess the pain after 1 hour, 3 hours, 24 hours, 48 hours and 72 hours of the injection.

Eligibility

Minimum Age: 48 Years

Eligible Ages: ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Qingdao Huinorde Science and Technology Co.,Ltd, Qingdao, Shandong, China

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

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