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Spots Global Cancer Trial Database for Thiopurine Methyltransferase Polymorphisms Evaluation

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Trial Identification

Brief Title: Thiopurine Methyltransferase Polymorphisms Evaluation

Official Title: Evaluation of Thiopurine Methyltransferase Polymorphisms in the Hispanic Population

Study ID: NCT00166647

Conditions

Cancer

Interventions

Blood Sampling

Study Description

Brief Summary: The purpose of the study is to determine the frequency of allelic variants in TPMT in the Hispanic population and to compare the frequency in the Hispanic population with the Caucasian Population.

Detailed Description: Relatively few studies have been performed evaluating the variant allele frequencies in Spanish populations. To date, no studies evaluating the TPMT variant allele frequency in the Hispanic population have been reported. Hispanics are a growing part of the patient population treated in the United States. Characterization of the proportion of patients with variant genotypes in this population is important since Hispanic children represent a significant proportion of children being treated with thiopurines. A single 3 cc heparinized blood sample will be obtained for TPMT genotyping. The sample will be obtained either simultaneously with a clinical sample, at the time of an otherwise medically indicated intravenous catheter placement or scavenged from excess blood remaining following clinical laboratory testing.

Eligibility

Minimum Age:

Eligible Ages: CHILD, ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, United States

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

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