Spots Global Cancer Trial Database for Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers

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Trial Identification

Brief Title: Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers

Official Title: Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers

Study ID: NCT02222844

Conditions

Cancer

Colorectal Neoplasms

Colon, Sigmoid

Magnetic Resonance Imaging

General Surgery

Interventions

Preoperative MRI scan

Study Description

Brief Summary: Patients with suspected or proven sigmoid colon adenocarcinoma, eligible for curative treatment whose MRI can be reviewed prior to surgery and has no decision regarding radical treatment are eligible. Patient are randomised to the control arm which the standard care of preoperative CT imaging and subsequent discussion by the Multidisciplinary Team or the interventional arm which has the additional use of MRI imaging and subsequent discussion by the Multidisciplinary Team. Patients are followed up at 1 and 3 years together with QoL questionnaires.

Detailed Description: A randomised phase II multicentre trial, IMPRESS will determine whether the use of MRI imaging in staging sigmoid cancers results in a change to the treatment plan by identifying more high risk tumours compared to those patients who were staged using CT imaging. The proposed intervention will be additional radiological and pathological assessment and the reporting of supplementary diagnostic information which would not otherwise have been available. This may affect treatment according to local MDT protocols and also affect the provision of prognostic information to patients in subsequent discussions.