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Cola

CT-imaging of chest and abdomen / pelvis before surgery (standard treatment)

Standard treatment plus an additional MRI scan before surgery

Standard preoperative CT of abdomen, chest and pelvis plus interventional preoperative MRI scan.

Preoperative MRI scan

Caroline Martin

Syvella Ellis

David Mitchell

Susan Donnelly

Chris Hough

Vanessa Adamson

Michael Braun

Helen Wilson

Anil Agarwal

Muti Abulafi

Ibiyemi Sadare

Lesley Stevenson

Harjeet Singh Narula

Anthony Higginson

Nicola Gibbons

Anthony Antoniou

Pooja Datt

Paulette Basham

Sukanya Ghosh

Sharon Turney

Jess Evans

Salim Kurrimboccus

Joanne Allsop

Salim Kurrimbossus

Sarah Duff

Lindsay Piper

David Leinhardt

Lisa Jones

Jan Ashcroft

Erica Beaumont

Cordelia Grant

Irene Chong, MD

Graham Branagan

Ruth Casey

Gina Brown

Patients with suspected or proven sigmoid colon adenocarcinoma, eligible for curative treatment whose MRI can be reviewed prior to surgery and has no decision regarding radical treatment are eligible. Patient are randomised to the control arm which the standard care of preoperative CT imaging and subsequent discussion by the Multidisciplinary Team or the interventional arm which has the additional use of MRI imaging and subsequent discussion by the Multidisciplinary Team. Patients are followed up at 1 and 3 years together with QoL questionnaires.

A randomised phase II multicentre trial, IMPRESS will determine whether the use of MRI imaging in staging sigmoid cancers results in a change to the treatment plan by identifying more high risk tumours compared to those patients who were staged using CT imaging. The proposed intervention will be additional radiological and pathological assessment and the reporting of supplementary diagnostic information which would not otherwise have been available. This may affect treatment according to local MDT protocols and also affect the provision of prognostic information to patients in subsequent discussions.

Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers

Direct comparison of proportion of patients staged as high and low risk for recurrence between CT vs MRI findings

Direct comparison of proportion of patients undergoing preoperative treatment or extended surgery between patients staged with CT vs MRI

Comparison of proportion of recurrences in patients staged as low vs high risk on CT vs MRI

Kaplan-Meier curves of disease free survival in patients staged as low vs high risk on CT vs MRI

Grade of specimen using pathology TNM8 stratified by TNM8 staging on CT vs MRI

CRM positivity rates on pathology in patients staged as low vs high risk on CT vs MRI

Comparison of proportion of patients staged as low vs high risk on CT vs MRI with pathology high and low risk and against outcomes

Comparison of perioperative morbidity of patients stratified by preoperative treatment between patients staged with CT vs MRI

Comparison of quality of life between patients staged with CT vs MRI by questionnaire (EORTC QLQ-CR29)

Comparison of proportion of stomas not reversed within 3 years postoperative follow-up in patients staged with CT vs MRI

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers	NCT02222844	Cancer Colorectal Neop... Colon, Sigmoid Magnetic Resona... General Surgery	Preoperative MR...	16 Years -	Imperial College London
Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers	NCT02222844	Cancer Colorectal Neop... Colon, Sigmoid Magnetic Resona... General Surgery	Preoperative MR...	16 Years -	Imperial College London

Spots Global Cancer Trial Database for colon, sigmoid