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Spots Global Cancer Trial Database for Detection of Peritoneal Metastasis of Gastric Cancer by Liquid Biopsy in Peripheral Blood: A Prospective Study

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Trial Identification

Brief Title: Detection of Peritoneal Metastasis of Gastric Cancer by Liquid Biopsy in Peripheral Blood: A Prospective Study

Official Title: Detection of Peritoneal Metastasis of Gastric Cancer by Liquid Biopsy in Peripheral Blood: A Prospective Study

Study ID: NCT05347524

Conditions

Cancer

Study Description

Brief Summary: This study is a prospective, multi-omics, observational study aimed at detecting peritoneal metastasis of gastric cancer by combined assays for methylation of cell-free DNA (cfDNA) and other blood-based biomarkers. The study will enroll 384 participants with gastric cancer.

Detailed Description: Peritoneal metastasis (PM) in gastric cancer is associated with a poor prognosis. Laparoscopy with cytology is performed to evaluate for peritoneal spread when considering chemoradiation or surgery. However, the laparoscopy is invasive and the sensitivity of computed tomography (CT) scan is poor for detecting PM. Therefore, it is necessary to evaluate the feasibility of cfDNA methylation and other blood-based biomarkers for the PM diagnosis. The study will enroll 384 participants with gastric cancer. Baseline blood and diagnosis of PM by laparoscopy with cytology will be collected. Participants with PM will be defined as the case arm and participants without PM will be defined as the control arm. A PM diagnostic model will be developed.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

ZhongShan Hospital, Fudan university, Shanghai, China, Shanghai, Shanghai, China

Contact Details

Name: Yihong Sun, Ph. D

Affiliation: Zhongshan Hospital, Fudan University, Shanghai, China

Role: PRINCIPAL_INVESTIGATOR

Name: Xuefei Wang, Ph. D

Affiliation: Zhongshan Hospital, Fudan University, Shanghai, China

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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