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Spots Global Cancer Trial Database for Pembrolizumab Plus Lenvatinib in Combination With Belzutifan in Solid Tumors (MK-6482-016)

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Trial Identification

Brief Title: Pembrolizumab Plus Lenvatinib in Combination With Belzutifan in Solid Tumors (MK-6482-016)

Official Title: An Open-label, Multicenter, Phase 2 Study to Evaluate the Efficacy and Safety of Pembrolizumab Plus Lenvatinib in Combination With Belzutifan in Multiple Solid Tumors

Study ID: NCT04976634

Study Description

Brief Summary: The purpose of this study is to determine the safety and efficacy of belzutifan in combination with pembrolizumab and lenvatinib in multiple solid tumors including hepatocellular carcinoma (HCC), colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC), biliary tract cancer (BTC), endometrial cancer (EC),and esophageal squamous cell carcinoma (ESCC). There is no formal hypothesis testing in this study.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of Arizona Cancer Center-University of Arizona Cancer Center - North Campus ( Site 5047), Tucson, Arizona, United States

City of Hope Comprehensive Cancer Center ( Site 5002), Duarte, California, United States

Cedars-Sinai Medical Center ( Site 5045), Los Angeles, California, United States

UCSF Medical Center at Mission Bay ( Site 5021), San Francisco, California, United States

Yale-New Haven Hospital-Yale Cancer Center ( Site 5013), New Haven, Connecticut, United States

Sibley Memorial Hospital ( Site 5051), Washington, District of Columbia, United States

University of Florida College of Medicine ( Site 5015), Gainesville, Florida, United States

Johns Hopkins Hospital-Sidney Kimmel Comprehensive Cancer Center - GI and Immunology ( Site 5048), Baltimore, Maryland, United States

Brigitte Harris Cancer Pavilion ( Site 5055), Detroit, Michigan, United States

Memorial Sloan Kettering Cancer Center ( Site 5050), New York, New York, United States

Duke Cancer Institute ( Site 5026), Durham, North Carolina, United States

University of Texas MD Anderson Cancer Center-Gastrointestinal Medical Oncology ( Site 5049), Houston, Texas, United States

Inova Schar Cancer Institute ( Site 5039), Fairfax, Virginia, United States

Blue Ridge Cancer Care ( Site 5053), Roanoke, Virginia, United States

Northwest Medical Specialties, PLLC ( Site 5025), Tacoma, Washington, United States

University of Wisconsin Hospitals and Clinics ( Site 5037), Madison, Wisconsin, United States

Gosford Hospital-Oncology Trials ( Site 4004), Gosford, New South Wales, Australia

Westmead Hospital-Department of Medical Oncology ( Site 4001), Westmead, New South Wales, Australia

Northern Hospital-Department of Medical Oncology ( Site 4003), Epping, Victoria, Australia

Cabrini Hospital - Malvern-Cabrini Institute ( Site 4000), Malvern, Victoria, Australia

Antwerp University Hospital-Oncology ( Site 1002), Edegem, Antwerpen, Belgium

Cliniques universitaires Saint-Luc-Medical Oncology ( Site 1001), Brussels, Bruxelles-Capitale, Region De, Belgium

Université Catholique de Louvain-Namur - Centre Hospitalier -Oncology ( Site 1003), Yvoir, Namur, Belgium

UZ Leuven ( Site 1000), Leuven, Vlaams-Brabant, Belgium

AZ Delta vzw ( Site 1004), Roeselare, West-Vlaanderen, Belgium

Centro Investigación del Cáncer James Lind ( Site 3107), Temuco, Araucania, Chile

Clínica Puerto Montt ( Site 3110), Puerto Montt, Los Lagos, Chile

FALP-UIDO ( Site 3102), Santiago, Region M. De Santiago, Chile

Oncovida ( Site 3108), Santiago, Region M. De Santiago, Chile

Bradfordhill-Clinical Area ( Site 3100), Santiago, Region M. De Santiago, Chile

Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 1103), Rennes, Bretagne, France

CHU Besançon-Medical oncology ( Site 1101), Besançon, Doubs, France

CHU Brest Cavale Blanche ( Site 1107), Brest, Finistere, France

Institut Régional du Cancer Montpellier ( Site 1106), Montpellier, Herault, France

Hôpital Beaujon-Oncologie Digestive ( Site 1104), Clichy, Ile-de-France, France

Centre Hospitalier Universitaire de Grenoble-Medical Oncology ( Site 1105), La Tronche, Isere, France

Sainte Catherine Institut du Cancer Avignon Provence ( Site 1108), Avignon, Vaucluse, France

Rambam Health Care Campus-Oncology ( Site 1300), Haifa, , Israel

Hadassah Medical Center-Oncology ( Site 1303), Jerusalem, , Israel

Sheba Medical Center-ONCOLOGY ( Site 1302), Ramat Gan, , Israel

Sourasky Medical Center-Oncology ( Site 1301), Tel Aviv, , Israel

Chonnam National University Hwasun Hospital-Hemato-Oncology ( Site 4105), Hwasun Gun, Jeonranamdo, Korea, Republic of

Keimyung University Dongsan Hospital CRC room 1 ( Site 4104), Daegu, Taegu-Kwangyokshi, Korea, Republic of

Seoul National University Hospital-Internal Medicine ( Site 4103), Seoul, , Korea, Republic of

Severance Hospital, Yonsei University Health System-Medical oncology ( Site 4100), Seoul, , Korea, Republic of

Asan Medical Center-Department of Oncology ( Site 4101), Seoul, , Korea, Republic of

Samsung Medical Center-Division of Hematology/Oncology ( Site 4102), Seoul, , Korea, Republic of

Maastricht UMC+-Medical Oncology ( Site 1501), Maastricht, Limburg, Netherlands

Leids Universitair Medisch Centrum-Medical Oncology ( Site 1504), Leiden, Zuid-Holland, Netherlands

Universitair Medisch Centrum Utrecht-Medical Oncology ( Site 1503), Utrecht, , Netherlands

Auckland City Hospital-Liver Research Unit ( Site 4201), Grafton, Auckland, New Zealand

Auckland City Hospital-Cancer & Blood Research ( Site 4200), Auckland, , New Zealand

Hospital Universitario Central de Asturias-Medical Oncology ( Site 1802), Oviedo, Asturias, Spain

Hospital Germans Trias i Pujol-Instituto Catalán de Oncología de Badalona ( Site 1806), Badalona, Barcelona, Spain

CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 1807), Santiago de Compostela, La Coruna, Spain

HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 1801), Madrid, Madrid, Comunidad De, Spain

Hospital Universitari Vall d'Hebron-Oncology ( Site 1800), Barcelona, , Spain

Contact Details

Name: Medical Director

Affiliation: Merck Sharp & Dohme LLC

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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