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Brief Title: Circulating Tumor DNA Longitudinal Monitoring in Stage III-IV Lung Cancer Patients
Official Title: A Prospective Multicenter Study of Longitudinal Monitoring in Treated Stage III-IV Lung Cancer Patients by Circulating Tumor DNA
Study ID: NCT03664843
Brief Summary: Conduct a prospective study in multicenter to confirm the value of circulating tumor DNA in longitudinal monitoring of stage III-IV lung cancer patients.
Detailed Description: The study consists of two phases, the first stage is the exploratory stage of blood collection point which is the appropriate effective time after chemotherapy, radiotherapy, targeted therapy. The second phase, which is the expansion of the first phase, is to determine the precise leading time of ctDNA relative to tumor biomarkers or image evaluation in determining the efficacy of advanced NSCLC cancer therapy. Both stages were divided into three subgroups: the chemotherapy group, the radiotherapy group, and the targeted therapy group.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Peking University People's Hospital, Beijing, Beijing, China
Affiliated Hospital of Hebei University, Baoding, Hebei, China
Hebei Medical University Fourth Hospital, Shijiazhuang, Hebei, China
The First Hospital of Shijiazhuang, Shijiazhuang, Hebei, China
Xingtai People's Hospital, Xingtai, Hebei, China
Handan Downtown Hospital, Handan, Heibe, China
Tianjin Medical University Cancer Institute and Hospital, Tianjin, Tianjin, China
Tianjin Medical University General Hospital, Tianjin, Tianjin, China
Name: Yan Zhang, M.D.
Affiliation: The First Hospital of Shijiazhuang
Role: PRINCIPAL_INVESTIGATOR
Name: Jun Wang, M.D.
Affiliation: Peking University People's Hospital
Role: STUDY_CHAIR
Name: Kezhong Chen, M.D.
Affiliation: Peking University People's Hospital
Role: STUDY_DIRECTOR