Spots Global Cancer Trial Database for circulating tumor dna
Every month we try and update this database with for circulating tumor dna cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Circulating Tumor DNA to Monitor Response to Neoadjuvant Chemotherapy in Breast Cancer | NCT03260192 | Breast Cancer | 18 Years - 70 Years | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | ||
| An Investigational Immuno-therapy Study of Nivolumab Given After Surgery in Non-Small Cell Lung Cancer (NSCLC) Participants With Minimal Residual Disease | NCT03770299 | Non-Small Cell ... Non-Small-Cell ... Circulating Tum... | Nivolumab Vinorelbine Gemcitabine Docetaxel Pemetrexed Cisplatin Carboplatin Paclitaxel Observation | 18 Years - | Bristol-Myers Squibb | |
| Multicenter, Prospective, RCT：Investigation of Combined Modality Therapy for Locally Advanced Mid/Low Rectal Cancer. | NCT03042000 | Rectal Cancer, ... Neoadjuvant Che... | non-NCRT NCRT capecitabine wi... capecitabine TEM radical resecti... | 18 Years - 75 Years | Peking Union Medical College Hospital | |
| CIRculating Cell-free nUcLeic Acids in Cancer Therapy Monitoring -01 | NCT05871593 | Next-Generation... | Molecular genet... | 18 Years - | University Hospital Tuebingen | |
| Circulating Tumor DNA Study in Patients With Endometrial Cancer | NCT05955079 | Endometrial Can... | Whole blood | 18 Years - | Assistance Publique - Hôpitaux de Paris | |
| Dynamic Monitoring Circulating Tumor DNA in Surgical Patients With Lung Cancer | NCT03317080 | Lung Cancer | - | West China Hospital | ||
| DANISH.MRD: Danish Assessment of Minimal Residual Disease by Liquid Biopsies | NCT06076811 | Colorectal Neop... Colorectal Canc... Colorectal Aden... Colorectal Canc... Colorectal Canc... Colorectal Canc... | 18 Years - | University of Aarhus | ||
| ctDNA-guided Adjuvant Chemotherapy in Liver Metastasis of Colorectal Cancer | NCT05815082 | Colorectal Canc... Liver Metastase... Circulating Tum... Chemotherapy Ef... | Colorectal canc... FOLFOX chemothe... | 18 Years - 75 Years | Sixth Affiliated Hospital, Sun Yat-sen University | |
| Clinical Sensitivity Verification Study of Circulating Tumor Cells Gene Mutation Detection From Advanced NSCLC Patients | NCT04229121 | Advanced NSCLC Circulating Tum... Circulating Tum... | nonintervention | 18 Years - | Shanghai Pulmonary Hospital, Shanghai, China | |
| SCION: SABR and Checkpoint Inhibition Of NSCLC | NCT04944173 | Non Small Cell ... Carcinoma, Non-... Non-small Cell ... Lung Cancer Lung Cancer Sta... Lung Adenocarci... Lung Squamous C... | Durvalumab Stereotactic Bo... Circulating Tum... | 18 Years - | University of British Columbia | |
| Initial Attack on Latent Metastasis Using TAS-102 for ct DNA Identified Colorectal Cancer Patients After Curative Resection | NCT04457297 | Colorectal Neop... Trifluridine an... Circulating Tum... | trifluridine an... Placebo | 20 Years - | National Cancer Center Hospital East | |
| Predictive Value of Postoperative Circulating Tumor DNA Monitoring for Colorectal Cancer Recurrence | NCT06143644 | Colorectal Canc... | Serial ctDNA mo... | 18 Years - | Sun Yat-sen University | |
| The Oncopanel Pilot (TOP) Study | NCT02171286 | Colorectal Canc... Advanced Non-Sm... Advanced Melano... Gastrointestina... Patients With D... | 18 Years - | British Columbia Cancer Agency | ||
| Concordance Between ctDNA Assay and FoundationOne | NCT02620527 | Circulating Tum... Cancer Neoplasms Genomic Testing Genomic Alterat... | 18 Years - | Foundation Medicine | ||
| KIDSTAGE- Staging of Kidney Cancer Using Dual Time PET/CT and Other Biomarkers | NCT04295174 | Carcinoma, Rena... | 18 Years - | Odense University Hospital | ||
| Liquid Biopsies for Improving the Pre-operative Diagnosis of Ovarian Cancer | NCT04971421 | Ovarian Neoplas... | ctDNA - circula... TEP - Tumor Edu... | 18 Years - | The Netherlands Cancer Institute | |
| Circulating Tumor DNA Detection in Surveillance of Surgical Lung Cancer Patients | NCT02696525 | Carcinoma Non-small-cell ... Lung Neoplasms | 18 Years - 80 Years | Peking University People's Hospital | ||
| Clinical Value of MRD Monitoring for Adjuvant Therapy in Postoperative NSCLC | NCT05167604 | Carcinoma, Non-... Next-Generation... Chemotherapy, A... Neoplasm, Resid... Circulating Tum... | Adjuvants, Phar... | 18 Years - 70 Years | Tang-Du Hospital | |
| Cell-free DNA From Junction of Hepatitis B Virus Integration in HCC Patients for Monitoring Post-resection Recurrence | NCT05823584 | Hepatocellular ... | 20 Years - | TCM Biotech International Corp. | ||
| Early Diagnosis of Small Pulmonary Nodules by Multi-omics Sequencing | NCT03320044 | Carcinoma Non-small-cell ... Lung Neoplasm | 18 Years - | Peking University People's Hospital | ||
| Kinetics of Circulating Tumor DNA in Lymphoma Treated by Immuno-chemotherapy | NCT06141772 | Diffuse Large B... | Measure of the ... | 18 Years - | Centre Henri Becquerel | |
| Prognostic and Predictive Impact of Circulating Tumor DNA in Gastric Cancer Treatment | NCT02674373 | Gastric Cancer | 18 Years - | Association des Gastroentérologues Oncologues | ||
| KIDNEY-PAGER: Analysis of Circulating Tumor DNA as a Biomarker in Renal Cancer - an Observational Trial | NCT06145139 | Renal Cancer | 18 Years - | University of Aarhus | ||
| Application of Circulating Tumor DNA Test in the Diagnosis and Treatment of Patients With Advanced Rectal Cancer | NCT03615170 | Rectal Neoplasm... Neoadjuvant The... Circulating Tum... | 18 Years - 80 Years | Zhejiang Cancer Hospital | ||
| CIrculating Tumor DNA for Monitoring Response to First Line Chemotherapy in Unresectable PANcreatic Cancer | NCT04560270 | Pancreatic Canc... Circulating Tum... KRAS Mutation-R... | Blood samples | 18 Years - | Poitiers University Hospital | |
| Circulating Tumor DNA Longitudinal Monitoring in Stage III-IV Lung Cancer Patients | NCT03664843 | Carcinoma Non-small Cell ... Lung Neoplasm | 18 Years - 80 Years | First Hospital of Shijiazhuang City | ||
| Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA) | NCT04434040 | Breast Cancer Triple Negative... Residual Cancer Circulating Tum... | Atezolizumab Sacituzumab gov... | 18 Years - | Dana-Farber Cancer Institute | |
| Personalised Disease Monitoring in Metastatic Breast Cancer | NCT04597580 | Breast Cancer M... Estrogen Recept... | 18 Years - | The Christie NHS Foundation Trust | ||
| Study of Circulating Tumoral DNA in Metastatic Choroidal Melanoma | NCT01334008 | Choroidal Melan... | Blood sampling | 18 Years - | Institut Curie | |
| Exploration of Adaptive Antitumoral Immune Cells Through Lymphapheresis in Cancer Patients : ALCYTA | NCT05354765 | Cancer Immune System o... | blood sample blood sample | 18 Years - | Institut Curie | |
| Non-Invasive Artificial Intelligence-Based Platform MonIToring Program (NIP IT!) | NCT05196087 | Breast Cancer Melanoma Gastrointestina... | 18 Years - | University Health Network, Toronto | ||
| DANISH.MRD: Danish Assessment of Minimal Residual Disease by Liquid Biopsies | NCT06076811 | Colorectal Neop... Colorectal Canc... Colorectal Aden... Colorectal Canc... Colorectal Canc... Colorectal Canc... | 18 Years - | University of Aarhus | ||
| Influence of the Surgical Technique Used for Colectomies on the Concentration of Circulating Tumor DNA and the Presence of Circulating Tumor Cells: Comparison of the "no Touch" Technic With Either First Clamping of the Mesenteric Vessels or First Mobilization of the Tumor Followed by Clamping. | NCT03809403 | Colorectal Canc... | 18 Years - | Assistance Publique - Hôpitaux de Paris | ||
| Monitoring of Circulating Tumor DNA and Its Aberrant Methylation in the Surveillance of Surgical Lung Cancer Patients (MEDAL, MEthylation Based Dynamic Analysis for Lung Cancer). | NCT03634826 | Carcinoma Lung Cancer NSCLC Lung Neoplasm | 18 Years - 80 Years | Peking University People's Hospital | ||
| OPTIMIzation of Treatment SElection and Follow up in Oligometastatic Colorectal Cancer | NCT04680260 | Colorectal Canc... Metastatic Canc... | Standard of car... Circulating tum... | 18 Years - | Aarhus University Hospital | |
| Robotic Versus Open Pancreaticoduodenectomy for Pancreatic and Periampullary Tumors | NCT04400357 | Pancreatic Aden... Pancreatic Cyst... Pancreatic Endo... Chronic Pancrea... Cholangiocarcin... Ampullary Adeno... Duodenal Adenoc... | Robotic pancrea... Open pancreatic... | 18 Years - | Ruijin Hospital | |
| Feasibility Study of Multi-Platform Profiling of Resected Biliary Tract Cancer | NCT04561453 | Biliary Tract C... Cholangiocarcin... Gallbladder Can... Intrahepatic Ch... Perihilar Chola... Extrahepatic Ch... Hilar Cholangio... Distal Bile Duc... | Multi-Platform ... | 18 Years - | University of Washington | |
| CIrculating Tumor DNA for Monitoring Response to First Line Chemotherapy in Unresectable PANcreatic Cancer | NCT04560270 | Pancreatic Canc... Circulating Tum... KRAS Mutation-R... | Blood samples | 18 Years - | Poitiers University Hospital | |
| Dynamic Monitoring of ctDNA Methylation to Predict Relapse in Colorectal Cancer After Radical Resection (POSTCA) | NCT03737539 | Colorectal Canc... Circulating Tum... Surveillance Methylation | Multigene methy... | 18 Years - | Fudan University | |
| Circulating Tumor DNA (ctDNA) as a Prognostic Tool in Patients With Advanced Lung Adenocarcinoma | NCT03090815 | Adenocarcinoma ... | Sequencing of c... | 18 Years - 80 Years | The University of Hong Kong | |
| Circulating Tumor DNA Detection in Surveillance of Surgical Lung Cancer Patients | NCT02696525 | Carcinoma Non-small-cell ... Lung Neoplasms | 18 Years - 80 Years | Peking University People's Hospital | ||
| Circulating Tumor DNA to Monitor the Efficacy of Total Neoadjuvant Therapy for Rectal Cancer | NCT05356585 | Colorectal Canc... Rectal Cancer | SignateraTM ass... | 18 Years - | Case Comprehensive Cancer Center | |
| Using ctDNA to Determine Therapies for Lung Cancer | NCT04966663 | Non Small Cell ... Complete Surgic... Circulating Tum... | Nivolumab Pemetrexed Gemcitabine Cisplatin Carboplatin ctDNA blood tes... | 18 Years - | University Health Network, Toronto | |
| Application of ctDNA in Evaluation of Neoadjuvant Chemotherapy Efficacy and Exploration of Chemoresistance Mechanisms in Pancreatic Cancer | NCT05848154 | Patients With N... Evaluation of T... | ctDNA detection | 18 Years - 75 Years | Shanghai Zhongshan Hospital | |
| Robotic Versus Open Pancreaticoduodenectomy for Pancreatic and Periampullary Tumors | NCT04400357 | Pancreatic Aden... Pancreatic Cyst... Pancreatic Endo... Chronic Pancrea... Cholangiocarcin... Ampullary Adeno... Duodenal Adenoc... | Robotic pancrea... Open pancreatic... | 18 Years - | Ruijin Hospital | |
| Sweden Cancerome Analysis Network - Breast Recurrence (SCAN-B-rec) | NCT03758976 | Metastatic Brea... | Biopsies, blood | 18 Years - | Lund University Hospital | |
| Reliability and Interest of Circulating Tumor DNA in Endometrial Cancers. | NCT04456972 | Circulating Tum... Endometrial Can... | One arm only | 18 Years - | Poitiers University Hospital | |
| Treatment Of Metastatic Bladder Cancer at the Time Of Biochemical reLApse Following Radical Cystectomy | NCT04138628 | Bladder Cancer Bladder Cancer,... | Atezolizumab | 18 Years - | Aarhus University Hospital | |
| Methylation Analysis of Circulating Tumor DNA in Gastric Cancer | NCT04511559 | Stomach Neoplas... Circulating Tum... | Circulating Tum... tissue DNA Meth... | 18 Years - 75 Years | Shanghai Zhongshan Hospital | |
| ctDNA-MRD Based Adjuvant Targeted Therapy for EGFR Positive Stage I Lung Adenocarcinomas | NCT05079022 | Adenocarcinoma ... | Furmonertinib | 18 Years - | Peking University People's Hospital | |
| ctDNA-based Minimal Residual Disease Detection for Resected Pancreatic Adenocarcinoma | NCT05479708 | Pancreatic Canc... | ctDNA-based MRD... | 18 Years - 75 Years | Ruijin Hospital | |
| Comparison of Circulating Tumor DNA and Tumor Tissue DNA by Targeted Sequencing in Non-Small Cell Lung Cancer | NCT02645318 | Carcinoma, Non-... | 18 Years - | Peking University People's Hospital | ||
| Evaluation of Circulating Tumor DNA Guided Surveillance Strategy of Stage III Colorectal Cancer: an Open, Prospective, Randomized Controlled Cohort Study | NCT05161585 | Stage III Color... Circulating Tum... | ctDNA dynamic m... | 18 Years - 80 Years | Fudan University | |
| Early Detection of Treatment Failure in Metastatic Colorectal Cancer Patients | NCT05068531 | Colorectal Canc... | 18 Years - | Centre hospitalier de l'Université de Montréal (CHUM) | ||
| OPTImal PALliative Anti-epidermal Growth Factor Receptor Treatment in Metastatic Colorectal Cancer - | NCT03750175 | Colorectal Canc... Circulating Tum... KRAS Gene Mutat... NRAS Gene Mutat... BRAF Gene Mutat... Epidermal Growt... | Plasma circulat... | 18 Years - | Aarhus University Hospital | |
| Identifying Genomic Mutations of Multiple Primary Lung Cancers by Circulating Tumor DNA | NCT02833467 | Carcinoma Non-small-cell ... Thoracic Neopla... | 18 Years - | Peking University People's Hospital | ||
| Liquid Biopsy for ctDNA in Peritoneal Lavage and Blood in Pancreatic Cancer | NCT05400681 | Pancreatic Canc... Pancreatic Aden... | 20 Years - 100 Years | Odense University Hospital | ||
| Tocotrienol and Bevacizumab in Metastatic Colorectal Cancer | NCT04245865 | Colorectal Canc... | Fluorouracil Calcium folinat... Oxaliplatin Bevacizumab Capecitabine Tocotrienol Placebo | 18 Years - | Vejle Hospital | |
| Detect Microsatellite Instability Status in Blood Sample of Advanced Colorectal Cancer Patients by Next-Generation Sequencing | NCT03561350 | Colorectal Neop... | 18 Years - | Shanghai Minimally Invasive Surgery Center | ||
| Biomarkers for Risk Stratification in Lung Cancer | NCT03774758 | Nodule Solitary... Non-small Cell ... | Guardant Health... | 40 Years - | University of California, San Francisco | |
| Liquid Biopsies and Imaging in Breast Cancer | NCT04223492 | Breast Cancer | Liquid biopsy Multi-parametri... | 18 Years - | UMC Utrecht | |
| The Oncopanel Pilot (TOP) Study | NCT02171286 | Colorectal Canc... Advanced Non-Sm... Advanced Melano... Gastrointestina... Patients With D... | 18 Years - | British Columbia Cancer Agency | ||
| CtDNA as a Novel Biomarker of Treatment Efficacy in Patients With Ovarian Cancer | NCT05027828 | High-grade Sero... Circulating Tum... | 18 Years - | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | ||
| Potential of Circulating Tumor DNA to Assess the Tumor Response to Neoadjuvant Chemotherapy in Breast Cancer Patients | NCT03688035 | Breast Cancer Neoadjuvant Che... Circulating Tum... | 18 Years - 70 Years | Shandong Cancer Hospital and Institute | ||
| Clinical Utility of Selected Circulating Tumor DNA Assays in Patients With Advanced Malignancy | NCT06290856 | Metastatic Colo... Pancreas Adenoc... Cholangiocarcin... | Multiplex PCR-t... | 18 Years - | Oslo University Hospital | |
| Liquid Biopsy for ctDNA in Peritoneal Lavage and Blood in Pancreatic Cancer | NCT05400681 | Pancreatic Canc... Pancreatic Aden... | 20 Years - 100 Years | Odense University Hospital | ||
| Analysis of Circulating Tumor Markers in the Blood (ALCINA) | NCT02866149 | Cancer | Blood sampling Tumor sampling Stool sampling | 18 Years - | Institut Curie | |
| Circulating Biomarkers in Oropharyngeal Cancers | NCT05904327 | Oropharynx Squa... Oropharynx Canc... Tonsillar Cance... Base of the Ton... | - | Region Örebro County | ||
| The Sinai Robotic Surgery Trial in HPV-related Oropharyngeal Squamous Cell Carcinoma (SIRS 2.0 Trial) | NCT05419089 | HPV-positive Or... | Robotic surgery | 18 Years - | Icahn School of Medicine at Mount Sinai | |
| PROstate Cancer TReatment Optimization Via Analysis of Circulating Tumour DNA | NCT04015622 | Metastatic Cast... | Enzalutamide Docetaxel | 18 Years - | British Columbia Cancer Agency | |
| Using ctDNA to Determine Therapies for Lung Cancer | NCT04966663 | Non Small Cell ... Complete Surgic... Circulating Tum... | Nivolumab Pemetrexed Gemcitabine Cisplatin Carboplatin ctDNA blood tes... | 18 Years - | University Health Network, Toronto | |
| Monitoring of Circulating Tumor DNA and Its Aberrant Methylation in the Surveillance of Surgical Lung Cancer Patients (MEDAL, MEthylation Based Dynamic Analysis for Lung Cancer). | NCT03634826 | Carcinoma Lung Cancer NSCLC Lung Neoplasm | 18 Years - 80 Years | Peking University People's Hospital | ||
| Predicting the Efficacy and Prognosis of Rectal Cancer Patients Based on ctDNA-MRD Technology | NCT05969938 | Rectal Adenocar... Circulating Tum... Minimal Residua... Neoadjuvant Che... | MRD detection | 18 Years - 75 Years | Sun Yat-sen University | |
| Biomarkers of Stage III Locally Advanced Unresectable Non-small-cell Lung Cancer | NCT04749407 | Non-small Cell ... | biomarker detec... | 18 Years - 70 Years | First People's Hospital of Hangzhou | |
| Evaluation Interest of the Circulating Tumor DNA Dosage in Patient With Hepatic Metastatic Uveal Melanoma Candidate to Complete Resection (ct DNA R0) | NCT02849145 | Uveal Melanoma | Blood sampling | 18 Years - | Institut Curie | |
| Analysis of Circulating Tumor DNA to Monitor Metastatic Colorectal Cancer Treatment | NCT01983098 | To Compare the ... | 18 Years - | Assistance Publique - Hôpitaux de Paris | ||
| Liquid Biopsy for ctDNA in Peritoneal Lavage and Blood in Pancreatic Cancer | NCT05400681 | Pancreatic Canc... Pancreatic Aden... | 20 Years - 100 Years | Odense University Hospital | ||
| Cohort Study of Patients With Hepatocellular Carcinoma and Circulating Tumor DNA Monitoring of Chemoembolization | NCT05390112 | Circulating Tum... Hepatocellular ... Transarterial C... | DNA | 18 Years - | University Hospital, Rouen | |
| Predictive Value of Postoperative Circulating Tumor DNA Monitoring for Colorectal Cancer Recurrence | NCT06143644 | Colorectal Canc... | Serial ctDNA mo... | 18 Years - | Sun Yat-sen University | |
| Reliability and Interest of Circulating Tumor DNA in Endometrial Cancers. | NCT04456972 | Circulating Tum... Endometrial Can... | One arm only | 18 Years - | Poitiers University Hospital |
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