Spots Global Cancer Trial Database for An Investigational Scan (7T MRI) for the Imaging of Central Nervous System Tumors

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Trial Identification

Brief Title: An Investigational Scan (7T MRI) for the Imaging of Central Nervous System Tumors

Official Title: Validation of a Multi-Parametric Ultra-High Field MRI Protocol for Central Nervous System Malignancy

Study ID: NCT04539574

Conditions

Central Nervous System Neoplasm

Glioma

Metastatic Malignant Neoplasm in the Central Nervous System

Metastatic Malignant Solid Neoplasm

Interventions

7 Tesla Magnetic Resonance Imaging

Questionnaire Administration

Study Description

Brief Summary: This trial investigates how well 7T MRI scan works in imaging central nervous system tumors. Diagnostic procedures, such as 7T MRI, may help find and diagnose central nervous system tumors and help measure a patient's response to earlier treatment. The goal of this trial is to learn if a new MRI system can provide better quality images than a standard MRI.

Detailed Description: PRIMARY OBJECTIVE: I. To estimate the contrast-to-noise ratio (CNR) for several imaging modalities in brain malignancy as compared with normal brain parenchyma separately by type of malignancy and treatment status. SECONDARY OBJECTIVE: I. To assess the conspicuity of each imaging modality to differentiate radiation necrosis from progressive disease. EXPLORATORY OBJECTIVES: I. To assess patient experience in the 7 Tesla (7T) magnetic resonance imaging (MRI) system compared to their most recent MRI examination. II. To assess the typical significance values seen for areas of maximal brain activity associated with each functional MRI (fMRI) test. III. To assess the geometric distortion of a radiation planning sequence on a ultra-high field (UHF) system. OUTLINE: Patients undergo 7T MRI over 60 minutes.