Spots Global Cancer Trial Database for Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer
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Trial Identification
Brief Title: Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer
Official Title: Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer
Study ID: NCT06208657
Study Description
Brief Summary: A companion platform trial to test novel targeted agents based on the patient's tumor profile.
Detailed Description: Both Australia (Zero Childhood Cancer) and Canada (PROFYLE) have developed precision oncology programs for the pediatric population through which samples from childhood/adolescent cancers undergo in depth genetic profiling. OPTIMISE is a companion platform trial, which will link patients to novel targeted agents based on their tumor profile. The trial will have multiple basket arms based on the most common genetically altered pathways the investigators have identified in these childhood cancers. Each arm of the trial will be histopathology agnostic and test a rational, novel combination therapy, to maximise potential clinical benefit.
Eligibility
Minimum Age: 0 Years
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Locations
John Hunter Children's Hospital, Newcastle, New South Wales, Australia
Sydney Children's Hospital, Randwick, Sydney, New South Wales, Australia
The Children's Hospital at Westmead, Sydney, New South Wales, Australia
Queensland Children's Hospital, Brisbane, Queensland, Australia
Women's and Children's Hospital, Adelaide, South Australia, Australia
Monash Children's Hospital, Melbourne, Victoria, Australia
Royal Children's Hospital, Melbourne, Victoria, Australia
Perth Children's Hospital, Perth, Western Australia, Australia
CHU Sainte Justine, Montréal, , Canada
The Hospital for Sick Children, Toronto, , Canada
BC Children's Hospital, Vancouver, , Canada
Contact Details
Name: David Ziegler, Prof
Affiliation: Sydney Children's Hospital - Australian Study Chair
Role: STUDY_CHAIR
Name: Daniel Morgenstern, Dr
Affiliation: The Hospital for Sick Children - Canadian Study Chair
Role: STUDY_CHAIR
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