Spots Global Cancer Trial Database for Study of Circulating Tumoral DNA in Metastatic Choroidal Melanoma
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Trial Identification
Brief Title: Study of Circulating Tumoral DNA in Metastatic Choroidal Melanoma
Official Title: Development and Validation of a Circulating Tumor DNA Detection Technique in Patients With Metastatic Choroidal Melanoma
Study ID: NCT01334008
Conditions
Interventions
Study Description
Brief Summary: Circulating tumor DNA detection and quantification in patients with metastatic choroidal melanoma.
Detailed Description: Technique development: In first step, the different available techniques will be evaluated for specificity and sensibility using serial dilutions of cell lines with or without GNAQ mutation. Validation: The tumor DNA detection rate will be estimated from metastatic uveal patient's blood. The investigators will study 40 patients to obtain at least 15 patients bearing a GNAQ mutation in the primitive tumor or in metastasis. With those 15 patients, the investigators will determinate the most sensitive technique and the best cost/efficiency ratio.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Institut Curie, Paris, , France
Contact Details
Name: Sophie PIPERNO-NEUMANN, MD
Affiliation: Institut Curie
Role: PRINCIPAL_INVESTIGATOR
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