Spots Global Cancer Trial Database for Reliability and Interest of Circulating Tumor DNA in Endometrial Cancers.
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Trial Identification
Brief Title: Reliability and Interest of Circulating Tumor DNA in Endometrial Cancers.
Official Title: Pilot Study on the Contribution of Molecular Analysis of Endometrial Cancers: Reliability, and Interest of Circulating Tumor DNA
Study ID: NCT04456972
Interventions
Study Description
Brief Summary: The recent histo-prognostic molecular discoveries of the TCGA (The Cancer Genome Atlas) have shed new light on the classification of endometrial carcinomas. After carrying out different types of high-throughput molecular analyzes on 373 endometrial carcinomas of different histological types, 4 major tumor subtypes could be identified, each with a different survival profile (the "ultra-mutated" group with POLE mutations, the "hypermuted" group with microsatellite instability (MSI), the "low number of copies" group, and the "high number of copies" group). This histomolecular classification is not yet directly transposable to clinical practice and tumor genetic characteristics have not had any direct therapeutic impact to date. The main objective of the study is to determine the concordance rate between molecular analysis of tumor tissue and that of cDNA in patients with endometrial cancer during treatment.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
CHU Poitiers, PRC, Poitiers, , France
Contact Details
Name: Camille Mrs EVRARD, PHD
Affiliation: CHU Poitiers
Role: PRINCIPAL_INVESTIGATOR
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