Spots Global Cancer Trial Database for Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases
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Trial Identification
Brief Title: Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases
Official Title: A Phase II, Multi-centre Study, of Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases From Non-small Cell Lung Cancer and Renal Cell Cancer
Study ID: NCT02978404
Study Description
Brief Summary: Stereotactic radiosurgery (SRS) is increasingly administered as the sole treatment of brain metastases, in order to spare acute and long term side effects associated with whole brain radiotherapy. Local control of SRS treated lesions is good, but patients tend to develop additional brain metastases subsequently. Nivolumab is a modulator of the immune system. Treatment with Nivolumab is associated with an increase in local control and survival in patients with non-small cell lung cancer and clear cell renal cell carcinoma. In the presence of Nivolumab, treatment of brain metastases with SRS may trigger an immune reaction against cancer. Therefore, the combination of SRS with Nivolumab may reduce the development of new brain metastases and improve patient survival. The purpose of this study is to assess the effect of combining Nivolumab and SRS in controlling cancer progression. SRS will be administered to patients while they are receiving Nivolumab.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada
McGill University Health Centre, Montreal, Quebec, Canada
Jewish General Hospital, Montréal, Quebec, Canada
Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada
Contact Details
Name: Philip Wong, MD, FRCPC
Affiliation: Centre hospitalier de l'Université de Montréal (CHUM)
Role: PRINCIPAL_INVESTIGATOR
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