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Spots Global Cancer Trial Database for Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases

Official Title: A Phase II, Multi-centre Study, of Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases From Non-small Cell Lung Cancer and Renal Cell Cancer

Study ID: NCT02978404

Study Description

Brief Summary: Stereotactic radiosurgery (SRS) is increasingly administered as the sole treatment of brain metastases, in order to spare acute and long term side effects associated with whole brain radiotherapy. Local control of SRS treated lesions is good, but patients tend to develop additional brain metastases subsequently. Nivolumab is a modulator of the immune system. Treatment with Nivolumab is associated with an increase in local control and survival in patients with non-small cell lung cancer and clear cell renal cell carcinoma. In the presence of Nivolumab, treatment of brain metastases with SRS may trigger an immune reaction against cancer. Therefore, the combination of SRS with Nivolumab may reduce the development of new brain metastases and improve patient survival. The purpose of this study is to assess the effect of combining Nivolumab and SRS in controlling cancer progression. SRS will be administered to patients while they are receiving Nivolumab.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada

McGill University Health Centre, Montreal, Quebec, Canada

Jewish General Hospital, Montréal, Quebec, Canada

Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada

Contact Details

Name: Philip Wong, MD, FRCPC

Affiliation: Centre hospitalier de l'Université de Montréal (CHUM)

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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