Spots Global Cancer Trial Database for Cellular Immune Augmentation in Colon and Rectal Cancer
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Trial Identification
Brief Title: Cellular Immune Augmentation in Colon and Rectal Cancer
Official Title: A Pilot Study of Cellular Immune Augmentation in Colon and Rectal Cancer Therapy
Study ID: NCT00257322
Interventions
Study Description
Brief Summary: While new treatments for metastatic and recurrent colorectal cancer have become available over the past several years, this disease remains incurable with a limited life expectancy from the time of diagnosis. New strategies for treatment of disseminated colorectal cancer are needed. Under this proposal, patients with advanced colorectal cancer will receive Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) to stimulate endogenous dendritic cells and enhance anti-tumor immune mechanisms. This will be combined with standard chemotherapy and patients will be followed for response and overall survival. Detailed correlative laboratory analysis will also be performed to define the extent of dendritic cell and cellular immune system stimulation.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Chao Family Comprehensive Cancer Center, Orange, California, United States
Contact Details
Name: Randall Holcombe, MD
Affiliation: Chao Family Comprehensive Cancer Center
Role: PRINCIPAL_INVESTIGATOR
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