Spots Global Cancer Trial Database for PEAK: Panitumumab Plus mFOLFOX6 vs. Bevacizumab Plus mFOLFOX6 for First Line Treatment of Metastatic Colorectal Cancer (mCRC) Patients With Wild-Type Kirsten Rat Sarcoma-2 Virus (KRAS) Tumors
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Trial Identification
Brief Title: PEAK: Panitumumab Plus mFOLFOX6 vs. Bevacizumab Plus mFOLFOX6 for First Line Treatment of Metastatic Colorectal Cancer (mCRC) Patients With Wild-Type Kirsten Rat Sarcoma-2 Virus (KRAS) Tumors
Official Title: A Randomized, Multicenter, Phase 2 Study to Compare the Efficacy of Panitumumab in Combination With mFOLFOX6 to the Efficacy of Bevacizumab in Combination With mFOLFOX6 in Patients With Previously Untreated, KRAS Wild-Type, Unresectable, Metastatic Colorectal Cancer
Study ID: NCT00819780
Study Description
Brief Summary: The primary objective of this study is to estimate the treatment effect on progression-free survival (PFS) of panitumumab relative to bevacizumab in combination with mFOLFOX6 chemotherapy as first-line therapy in patients with tumors expressing wild-type KRAS, unresectable mCRC.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Birmingham, Alabama, United States
Research Site, Huntsville, Alabama, United States
Research Site, Berkeley, California, United States
Research Site, Beverly Hills, California, United States
Research Site, Burbank, California, United States
Research Site, Fountain Valley, California, United States
Research Site, La Verne, California, United States
Research Site, Orange, California, United States
Research Site, Riverside, California, United States
Research Site, Roseville, California, United States
Research Site, Denver, Colorado, United States
Research Site, Stamford, Connecticut, United States
Research Site, Waterbury, Connecticut, United States
Research Site, Boynton Beach, Florida, United States
Research Site, Coral Springs, Florida, United States
Research Site, Daytona Beach, Florida, United States
Research Site, Hollywood, Florida, United States
Research Site, Lake Worth, Florida, United States
Research Site, Alpharetta, Georgia, United States
Research Site, Augusta, Georgia, United States
Research Site, Savannah, Georgia, United States
Research Site, Post Falls, Idaho, United States
Research Site, Gurnee, Illinois, United States
Research Site, Peoria, Illinois, United States
Research Site, Indianapolis, Indiana, United States
Research Site, Overland Park, Kansas, United States
Research Site, Wichita, Kansas, United States
Research Site, Danville, Kentucky, United States
Research Site, Hazard, Kentucky, United States
Research Site, Paducah, Kentucky, United States
Research Site, Baltimore, Maryland, United States
Research Site, Bethesda, Maryland, United States
Research Site, Boston, Massachusetts, United States
Research Site, Kalamazoo, Michigan, United States
Research Site, Lambertville, Michigan, United States
Research Site, Lansing, Michigan, United States
Research Site, Mountain Lakes, New Jersey, United States
Research Site, Sparta, New Jersey, United States
Research Site, Albuquerque, New Mexico, United States
Research Site, Buffalo, New York, United States
Research Site, East Setauket, New York, United States
Research Site, Staten Island, New York, United States
Research Site, Huntersville, North Carolina, United States
Research Site, Raleigh, North Carolina, United States
Research Site, Akron, Ohio, United States
Research Site, Columbus, Ohio, United States
Research Site, Hershey, Pennsylvania, United States
Research Site, Philadelphia, Pennsylvania, United States
Research Site, Greenville, South Carolina, United States
Research Site, Mount Pleasant, South Carolina, United States
Research Site, Memphis, Tennessee, United States
Research Site, Austin, Texas, United States
Research Site, Corpus Christi, Texas, United States
Research Site, Dallas, Texas, United States
Research Site, Round Rock, Texas, United States
Research Site, Temple, Texas, United States
Research Site, Tyler, Texas, United States
Research Site, White River Junction, Vermont, United States
Research Site, Chesapeake, Virginia, United States
Research Site, Newport News, Virginia, United States
Research Site, Newport News, Virginia, United States
Research Site, Spokane, Washington, United States
Research Site, Vancouver, Washington, United States
Research Site, Charleroi, , Belgium
Research Site, Edegem, , Belgium
Research Site, Libramont, , Belgium
Research Site, Sint-Niklaas, , Belgium
Research Site, Calgary, Alberta, Canada
Research Site, Edmonton, Alberta, Canada
Research Site, Vancouver, British Columbia, Canada
Research Site, Victoria, British Columbia, Canada
Research Site, Oshawa, Ontario, Canada
Research Site, Greenfield Park, Quebec, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Quebec, , Canada
Research Site, Berlin, , Germany
Research Site, Bielefeld, , Germany
Research Site, Magdeburg, , Germany
Research Site, München, , Germany
Research Site, München, , Germany
Research Site, Passau, , Germany
Research Site, Regensburg, , Germany
Research Site, Würzburg, , Germany
Research Site, Alba (CN), , Italy
Research Site, Fano, , Italy
Research Site, Genova, , Italy
Research Site, Mantova, , Italy
Research Site, Udine, , Italy
Research Site, Varese, , Italy
Research Site, Málaga, AndalucÃ-a, Spain
Research Site, Santander, Cantabria, Spain
Research Site, Sabadell, Cataluña, Spain
Research Site, Elche, Comunidad, Spain
Research Site, A Coruña, Galicia, Spain
Research Site, San Sebastián De Los Reyes, Madrid, Spain
Contact Details
Name: MD
Affiliation: Amgen
Role: STUDY_DIRECTOR
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