Spots Global Cancer Trial Database for FOLFOXIRI Plus Panitumumab in Metastatic RAS Wild-type, Left-sided Colorectal Cancer
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Trial Identification
Brief Title: FOLFOXIRI Plus Panitumumab in Metastatic RAS Wild-type, Left-sided Colorectal Cancer
Official Title: Phase II Pilot Study of FOLFOXIRI Plus Panitumumab in Metastatic RAS Wild-type, Left-sided Colorectal Cancer
Study ID: NCT04169347
Conditions
Interventions
Study Description
Brief Summary: This is a phase II, open-label, non-randomized study in subjects with histologically confirmed diagnosis of left-sided RAS WT advanced adenocarcinoma of the colon or rectum who have not received prior systemic therapy for metastatic disease.
Detailed Description: This trial is designed to evaluate the efficacy of the combination of FOLFOXIRI and panitumumab as first-line therapy in patients with metastatic, left-sided, RAS WT CRC. The research hypothesis is that in this cohort of patients, the combination of triplet chemotherapy and anti-EGFR therapy will confer higher response rates and efficacy.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Arizona Cancer Center, Tucson, Arizona, United States
Yale Cancer Center, New Haven, Connecticut, United States
Mount Sinai Comprehensive Cancer Center, Miami Beach, Florida, United States
University of Iowa Hospitals & Clinics, Iowa City, Iowa, United States
Kansas University Cancer Center, Westwood, Kansas, United States
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York, New York, United States
Swedish Cancer Institute, Seattle, Washington, United States
Contact Details
Name: Howard Hochster, MD
Affiliation: Lead Site PI
Role: PRINCIPAL_INVESTIGATOR
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