Spots Global Cancer Trial Database for Safety and Efficacy Study of Famitinib in Patients With Advanced Colorectal Adenocarcinoma（FACT）
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Trial Identification
Brief Title: Safety and Efficacy Study of Famitinib in Patients With Advanced Colorectal Adenocarcinoma（FACT）
Official Title: A Multicenter，Randomized, Double-blind, Placebo-controlled Trial of Famitinib in Patients With Advanced Colorectal Adenocarcinoma
Study ID: NCT02390947
Study Description
Brief Summary: Famitinib is a tyrosin-inhibitor agent targeting at c-Kit, VEGFR2, PDGFR, VEGFR3, Flt1 and Flt3, whose anti-tumor and anti-angiogenesis effects have been validated in preclinical tests. In PhaseⅡb study, a significantly improved Progression Free Survival (PFS) was found in patients with advanced colorectal cancer treated with Famitinib compared to placebo. On the other hand, the toxicity of Famitinib was manageable in both PhaseⅠand Ⅱb studies. The purpose of this study is to determine whether Famitinib can improve Overall Survival (OS) compared with placebo in total 540 patients with advanced colorectal cancer who have failed in previously received at least two lines of standard chemotherapy.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Beijing Cancer Hospital, Peking University, Beijing, Beijing, China
Beijing Chao-yang Hospital, Capital Medical University, Beijing, Beijing, China
Beijing Friendship Hospital, Capital Medical University, Beijing, Beijing, China
Chinese Academy of Medical Sciences Cancer Hospital, Beijing, Beijing, China
PLA Hospital 301, Beijing, Beijing, China
The Third Affiliated Hospital of The Third Military Medical University, Chongqing, Chongqing, China
Fujian Medical University Union Hospital, Fuzhou, Fujian, China
Cancer center, Sun Yet-sen University, Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangzhou Medical University of Chinese Medicine, Guangzhou, Guangdong, China
Cancer Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
Hainan General Hospital, Hainan, Hainan, China
Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China
The first affiliated hospital of Xinxiang medical university, Xinxiang, Henan, China
Cancer Hospital of Henan Province, Zhengzhou, Henan, China
The First affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Wuhan General Hospital of Guangzhou Military, Wuhan, Hubei, China
Cancer Hospital of Hunan Province, Changsha, Hunan, China
The Third Xiangya Hospital of Cental South University, Changsha, Hunan, China
The First People's Hospital of Changzhou, Changzhou, Jiangsu, China
Cancer Hospital of Jiangsu Province, Nanjing, Jiangsu, China
The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
The Affiliated Hospital of Xuzhou Medical Collage, Xuzhou, Jiangsu, China
Cancer Hospital of Jiangxi Province, Nanchang, Jiangxi, China
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
Cancer Hospital of Jilin province, Changchun, Jilin, China
The First Affiliated Hospital of Jilin University, Changchun, Jilin, China
Cancer Hospital of Liaoning Province, Shenyang, Liaoning, China
Chinese Medical University First Hospital, Shenyang, Liaoning, China
Fudan University Cancer Hospital, Shanghai, Shanghai, China
Ruijin Hospital, Shanghai jiaotong University, School of Medicine, Shanghai, Shanghai, China
Shanghai General Hospital, Shanghai, Shanghai, China
Zhongshan Hospital of Fudan University, Shanghai, Shanghai, China
Cancer Hospital of Shanxi Province, Xian, Shanxi, China
Tangdu Hospital of The Fouth Military Medical University, Xian, Shanxi, China
Cancer Hospital of Tianjin City, Tianjin, Tianjin, China
People's Hospital of Tianjin City, Tianjin, Tianjin, China
Cancer Hospital of Yunnan Province, Kunming, Yunnan, China
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China
The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Contact Details
Name: Lin Shen, M.D
Affiliation: Beijing Cancer Hospital, Peking University
Role: PRINCIPAL_INVESTIGATOR
Name: Ruihua Xu, M.D
Affiliation: Cancer Center, Sun Yet-sen University
Role: PRINCIPAL_INVESTIGATOR
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