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Brief Title: Detection of KRAS, NRAS et BRAF Mutations in Plasma Circulating DNA From Patients With Metastatic Colorectal Cancer
Official Title: Multicenter Prospective Study Comparing KRAS, NRAS and BRAF Mutation Testing Using OncoBEAM Technique in Plasma vs Conventional Techniques in Formalin Fixed Paraffin Embedded Tissues
Study ID: NCT02751177
Brief Summary: RAS genotyping is mandatory for the prescription of anti-EGFR (epidermal growth factor receptor) therapies in patients with metastatic colorectal cancer. The standard genotyping is assessed on formalin-fixed paraffin embedded tumour tissue. This study compares RAS and BRAF genotyping results achieved in analyzing circulating plasma DNA using OncoBEAM™ technique with those achieved using the standard genotyping techniques and formalin-fixed paraffin embedded samples.
Detailed Description: The study will be proposed to all patients with a metastatic colorectal cancer. Study information will be given to the patient during a routine medical examination. The patient will be included after checking inclusion criteria and signature of the informed consent form Blood sampling (30 ml) will be performed before the initiation of the first line metastatic chemotherapy.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
CH Auxerre, Auxerre, , France
CH Besançon-Hopital Jean Minjoz, Besançon, , France
CH Chalon Sur Saône-William Morey, Chalon Sur Saône, , France
Centre Georges François Leclerc Dijon, Dijon, , France
Hopital Belle-Isle-Metz, Metz, , France
Polyclinique de Gentilly, Nancy, , France
CHU Reims-Hôpital Robert Debré, Reims, , France
Polyclinique Courlancy Reims, Reims, , France
Centre Paul Stauss, Strasbourg, , France
CHRU Nancy, Vandœuvre-lès-Nancy, , France
Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, , France
Name: MERLIN JEAN LOUIS
Affiliation: Institut de Cancérologie de Lorraine
Role: STUDY_CHAIR
Name: HARLE ALEXANDRE
Affiliation: Institut de Cancérologie de Lorraine
Role: STUDY_CHAIR
Name: GAVOILLE CELINE, oncologist
Affiliation: Institut de Cancérologie de Lorraine
Role: PRINCIPAL_INVESTIGATOR