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Spots Global Cancer Trial Database for Detection of KRAS, NRAS et BRAF Mutations in Plasma Circulating DNA From Patients With Metastatic Colorectal Cancer

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Trial Identification

Brief Title: Detection of KRAS, NRAS et BRAF Mutations in Plasma Circulating DNA From Patients With Metastatic Colorectal Cancer

Official Title: Multicenter Prospective Study Comparing KRAS, NRAS and BRAF Mutation Testing Using OncoBEAM Technique in Plasma vs Conventional Techniques in Formalin Fixed Paraffin Embedded Tissues

Study ID: NCT02751177

Study Description

Brief Summary: RAS genotyping is mandatory for the prescription of anti-EGFR (epidermal growth factor receptor) therapies in patients with metastatic colorectal cancer. The standard genotyping is assessed on formalin-fixed paraffin embedded tumour tissue. This study compares RAS and BRAF genotyping results achieved in analyzing circulating plasma DNA using OncoBEAM™ technique with those achieved using the standard genotyping techniques and formalin-fixed paraffin embedded samples.

Detailed Description: The study will be proposed to all patients with a metastatic colorectal cancer. Study information will be given to the patient during a routine medical examination. The patient will be included after checking inclusion criteria and signature of the informed consent form Blood sampling (30 ml) will be performed before the initiation of the first line metastatic chemotherapy.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

CH Auxerre, Auxerre, , France

CH Besançon-Hopital Jean Minjoz, Besançon, , France

CH Chalon Sur Saône-William Morey, Chalon Sur Saône, , France

Centre Georges François Leclerc Dijon, Dijon, , France

Hopital Belle-Isle-Metz, Metz, , France

Polyclinique de Gentilly, Nancy, , France

CHU Reims-Hôpital Robert Debré, Reims, , France

Polyclinique Courlancy Reims, Reims, , France

Centre Paul Stauss, Strasbourg, , France

CHRU Nancy, Vandœuvre-lès-Nancy, , France

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, , France

Contact Details

Name: MERLIN JEAN LOUIS

Affiliation: Institut de Cancérologie de Lorraine

Role: STUDY_CHAIR

Name: HARLE ALEXANDRE

Affiliation: Institut de Cancérologie de Lorraine

Role: STUDY_CHAIR

Name: GAVOILLE CELINE, oncologist

Affiliation: Institut de Cancérologie de Lorraine

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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