Spots Global Cancer Trial Database for Matrilysin Expression in Different Stages of Colorectal Tumors
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Trial Identification
Brief Title: Matrilysin Expression in Different Stages of Colorectal Tumors
Official Title: Matrilysin Expression in Different Stages of Colorectal Tumors
Study ID: NCT01570452
Interventions
Study Description
Brief Summary: Matrix metalloproteinases (MMPs) have been shown to be involved in cancer biology. Significant expression of MMP-7 (matrilysin) in colorectal cancer is mainly associated with metastatic disease even though it is expressed in most tumor states. Our purpose is to analyse MMP-7 in bowel and lymph nodes of different tumor stages and to evaluate its expression as a potential biomarker of cancer disease in patients surgically treated for benign and malignant colorectal tumors. Tumoral tissue, lymph nodes and serum samples from recruited Patients plus serum samples from healthy volunteers are analysed for matrilysin expression by histology, immunohistochemistry, ELISA and Western blotting. If Matrilysin increases with increasing dysplasia and cancer disease stage in tumor tissue as well as in the regional lymph nodes it might be used as a complement in investigating suspected locally advanced cancer.
Detailed Description:
Eligibility
Minimum Age: 40 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Locations
Departement of Surgery Pietro Valdoni, Rome, , Italy
Contact Details
Name: Andrea Polistena, MD
Affiliation: Department of Surgery Pietro Valdoni, University La Sapienza Rome
Role: PRINCIPAL_INVESTIGATOR
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