Spots Global Cancer Trial Database for Mechanisms of Fate Evolution of Colorectal Adenocarcinoma Metastasis

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Trial Identification

Brief Title: Mechanisms of Fate Evolution of Colorectal Adenocarcinoma Metastasis

Official Title: a Multi-omics Cohort Study of Mechanisms of Fate Evolution of Colorectal Adenocarcinoma Metastasis

Study ID: NCT04714814

Conditions

Colorectal Cancer Stage III

Colorectal Cancer Stage IV

Interventions

Study Description

Brief Summary: This is a two stage nested case-control study to construct the hologram plane , explore biomarkers and screening original drugs of metastatic colorectal cancer.

Detailed Description: Stage Ⅰ is a cross-sectional study to record selected information and biospecimen of more than 200 colorectal cancer cases( at least 160 stage Ⅲ cases,40 stage Ⅳ（synchronous metastasis）).Stage Ⅱ is a nested case-control study. 200 eligible cases enrolled in phaseⅠwill be followed up for 5 years to record recurrence, metastasis and to collect biospecimen . Each case with the study outcome will be matched with the corresponding control according to the proportion of 1:1 according to age, sex and other conditions, and further analysis will be made.