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Spots Global Cancer Trial Database for Combination Chemotherapy Before or After Surgery in Treating Patients With Colorectal Cancer With Liver Metastases That Could Be Removed By Surgery

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Combination Chemotherapy Before or After Surgery in Treating Patients With Colorectal Cancer With Liver Metastases That Could Be Removed By Surgery

Official Title: A Phase III Study Evaluating the Role of Perioperative Chemotherapy in Patients With Potentially Resectable Hepatic Colorectal Metastases

Study ID: NCT01189227

Study Description

Brief Summary: RATIONALE: Drugs used in chemotherapy work in different ways to kill tumor cells or stop them from growing. Giving combination chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving combination chemotherapy after surgery may kill any remaining tumor cells. It is not yet known whether giving combination chemotherapy before and after surgery is more effective than giving combination chemotherapy after surgery. PURPOSE: This randomized phase III trial is studying giving combination chemotherapy before and after surgery to see how well it works compared to giving combination chemotherapy after surgery in treating patients with colorectal cancer with liver metastases that could be removed by surgery.

Detailed Description: OBJECTIVES: Primary * To evaluate the difference in recurrence-free survival (RFS) of patients with potentially resectable hepatic colorectal metastases receiving perioperative (preoperative plus postoperative) adjuvant chemotherapy vs only postoperative adjuvant chemotherapy following liver resection for colorectal metastases. Secondary * To compare the proportion of patients between study arms who are R0 or R1 resected, alive, and free of recurrence at 6 months. * To compare RFS between study arms in the cohort of patients event-free at 6 months. * To compare overall survival between study arms. * To evaluate the difference in R0 and combined R0 + R1 resection rates in patients receiving neoadjuvant therapy and those undergoing initial surgical resection. * To compare the postoperative morbidity profile between study arms. * To evaluate the safety and toxicity profile of postoperative and perioperative administration of chemotherapy and bevacizumab. Tertiary * To evaluate the relationship of baseline circulating tumor cells (CTC) to RFS. * To evaluate the relationship of baseline CTC to R0 resection. * To evaluate the relationship of pre-resection CTC in the preoperative therapy group only with RFS and R0 resection. OUTLINE: This is a multicenter study. Patients are stratified by number of liver metastases (1-3 vs 4+), chemotherapy regimen\* (mFOLFOX6 vs FOLFIRI), and synchronous\*\* primary colorectal cancer (yes vs no). Patients are randomized to 1 of 2 treatment arms. NOTE: \*Patients who have not received previous oxaliplatin receive mFOLFOX6 chemotherapy comprising oxaliplatin IV over 2 hours, leucovorin calcium IV over 2 hours, and fluorouracil IV over 46 hours on day 1. Patients who have received previous oxaliplatin receive FOLFIRI chemotherapy comprising irinotecan hydrochloride IV over 2 hours, leucovorin calcium IV over 2 hours, and fluorouracil IV over 46 hours on day 1. NOTE: \*\*Synchronous is defined as the detection (by imaging) of suspicious liver metastases within 90 days before or after the date of histologic diagnosis of the primary colon or rectal cancer. * Arm 1 (postoperative): Patients undergo hepatic resection. Beginning 31-56 days after surgery, patients receive mFOLFOX6 or FOLFIRI chemotherapy IV on day 1 over 3 hours. Patients receive an additional dose of fluorouracil over 46 hours using a portable pump. Treatment repeats every 2 weeks for 12 courses. * Arm 2 (perioperative): Patients receive mFOLFOX6 or FOLFIRI chemotherapy IV over 3 hours on day 1. Patients receive an additional dose of fluorouracil over 46 hours using a portable pump. Treatment repeats for every 2 weeks for 6 courses. Patients then undergo hepatic resection. Beginning 31-56 days after surgery, patients receive an additional 6 courses of mFOLFOX6 or FOLFIRI chemotherapy. Blood and tumor tissue samples may be collected periodically for correlative studies. After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Kaiser Permanente - Deer Valley, Antioch, California, United States

City of Hope Comprehensive Cancer Center, Duarte, California, United States

Kaiser Permanente - Fremont, Fremont, California, United States

Kaiser Permanente Medical Center - Hayward, Hayward, California, United States

Kaiser Permanente Medical Center - Oakland, Oakland, California, United States

St. Joseph Hospital Regional Cancer Center - Orange, Orange, California, United States

Kaiser Permanente Medical Center - Redwood City, Redwood City, California, United States

Kaiser Permanente Medical Center - Richmond, Richmond, California, United States

Kaiser Permanente Medical Center - Roseville, Roseville, California, United States

South Sacramento Kaiser-Permanente Medical Center, Sacramento, California, United States

Kaiser Permanente Medical Center - Sacramento, Sacramento, California, United States

Kaiser Permanente Medical Office -Vandever Medical Office, San Diego, California, United States

Kaiser Permanente Medical Center - San Francisco Geary Campus, San Francisco, California, United States

Kaiser Permanente Medical Center - Santa Teresa, San Jose, California, United States

Kaiser Foundation Hospital - San Rafael, San Rafael, California, United States

Kaiser Permanente Medical Center - Santa Clara Kiely Campus, Santa Clara, California, United States

Kaiser Permanente Medical Center - Santa Rosa, Santa Rosa, California, United States

Kaiser Permanente Medical Center - South San Francisco, South San Francisco, California, United States

Kaiser Permanente Medical Facility - Stockton, Stockton, California, United States

Kaiser Permanente Medical Center - Vacaville, Vacaville, California, United States

Kaiser Permanente Medical Center - Vallejo, Vallejo, California, United States

Kaiser Permanente Medical Center - Walnut Creek, Walnut Creek, California, United States

University of Colorado Cancer Center at UC Health Sciences Center, Aurora, Colorado, United States

Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center, Hartford, Connecticut, United States

Manchester Memorial Hospital, Manchester, Connecticut, United States

Tunnell Cancer Center at Beebe Medical Center, Lewes, Delaware, United States

CCOP - Christiana Care Health Services, Newark, Delaware, United States

Washington Cancer Institute at Washington Hospital Center, Washington, District of Columbia, United States

Baptist Cancer Institute - Jacksonville, Jacksonville, Florida, United States

Lakeland Regional Cancer Center at Lakeland Regional Medical Center, Lakeland, Florida, United States

Florida Hospital Cancer Institute at Florida Hospital Orlando, Orlando, Florida, United States

Veterans Affairs Medical Center - Atlanta (Decatur), Decatur, Georgia, United States

Kaiser Permanente - Moanalua Medical Center and Clinic, Honolulu, Hawaii, United States

Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center, Boise, Idaho, United States

St. Joseph Medical Center, Bloomington, Illinois, United States

Graham Hospital, Canton, Illinois, United States

Memorial Hospital, Carthage, Illinois, United States

Decatur Memorial Hospital Cancer Care Institute, Decatur, Illinois, United States

Eureka Community Hospital, Eureka, Illinois, United States

Galesburg Clinic, PC, Galesburg, Illinois, United States

Mason District Hospital, Havana, Illinois, United States

Hinsdale Hematology Oncology Associates, Hinsdale, Illinois, United States

McDonough District Hospital, Macomb, Illinois, United States

BroMenn Regional Medical Center, Normal, Illinois, United States

Community Cancer Center, Normal, Illinois, United States

Advocate Christ Medical Center, Oak Lawn, Illinois, United States

Community Hospital of Ottawa, Ottawa, Illinois, United States

Cancer Treatment Center at Pekin Hospital, Pekin, Illinois, United States

Proctor Hospital, Peoria, Illinois, United States

CCOP - Illinois Oncology Research Association, Peoria, Illinois, United States

Oncology Hematology Associates of Central Illinois, PC - Peoria, Peoria, Illinois, United States

Methodist Medical Center of Illinois, Peoria, Illinois, United States

OSF St. Francis Medical Center, Peoria, Illinois, United States

Illinois Valley Community Hospital, Peru, Illinois, United States

Perry Memorial Hospital, Princeton, Illinois, United States

Regional Cancer Center at Memorial Medical Center, Springfield, Illinois, United States

St. Francis Hospital and Health Centers - Beech Grove Campus, Beech Grove, Indiana, United States

Elkhart Clinic, LLC, Elkhart, Indiana, United States

Howard Community Hospital, Kokomo, Indiana, United States

Reid Hospital & Health Care Services, Richmond, Indiana, United States

CCOP - Northern Indiana CR Consortium, South Bend, Indiana, United States

Michiana Hematology-Oncology, PC - South Bend, South Bend, Indiana, United States

McFarland Clinic, PC, Ames, Iowa, United States

Medical Oncology and Hematology Associates - West Des Moines, Clive, Iowa, United States

Mercy Cancer Center - West Lakes, Clive, Iowa, United States

CCOP - Iowa Oncology Research Association, Des Moines, Iowa, United States

John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines, Iowa, United States

Medical Oncology and Hematology Associates at John Stoddard Cancer Center, Des Moines, Iowa, United States

Medical Oncology and Hematology Associates at Mercy Cancer Center, Des Moines, Iowa, United States

Mercy Cancer Center at Mercy Medical Center - Des Moines, Des Moines, Iowa, United States

John Stoddard Cancer Center at Iowa Lutheran Hospital, Des Moines, Iowa, United States

Holden Comprehensive Cancer Center at University of Iowa, Iowa City, Iowa, United States

McCreery Cancer Center at Ottumwa Regional, Ottumwa, Iowa, United States

Siouxland Hematology-Oncology Associates, LLP, Sioux City, Iowa, United States

Mercy Medical Center - Sioux City, Sioux City, Iowa, United States

St. Luke's Regional Medical Center, Sioux City, Iowa, United States

Cancer Center of Kansas, PA - Chanute, Chanute, Kansas, United States

Cancer Center of Kansas, PA - Dodge City, Dodge City, Kansas, United States

Cancer Center of Kansas, PA - El Dorado, El Dorado, Kansas, United States

Cancer Center of Kansas - Fort Scott, Fort Scott, Kansas, United States

Cancer Center of Kansas-Independence, Independence, Kansas, United States

Cancer Center of Kansas, PA - Kingman, Kingman, Kansas, United States

Lawrence Memorial Hospital, Lawrence, Kansas, United States

Cancer Center of Kansas, PA - Liberal, Liberal, Kansas, United States

Cancer Center of Kansas, PA - Newton, Newton, Kansas, United States

Menorah Medical Center, Overland Park, Kansas, United States

Saint Luke's Hospital - South, Overland Park, Kansas, United States

Cancer Center of Kansas, PA - Parsons, Parsons, Kansas, United States

CCOP - Kansas City, Prairie Village, Kansas, United States

Cancer Center of Kansas, PA - Pratt, Pratt, Kansas, United States

Cancer Center of Kansas, PA - Salina, Salina, Kansas, United States

Cancer Center of Kansas, PA - Wellington, Wellington, Kansas, United States

Associates in Womens Health, PA - North Review, Wichita, Kansas, United States

Cancer Center of Kansas, PA - Medical Arts Tower, Wichita, Kansas, United States

Cancer Center of Kansas, PA - Wichita, Wichita, Kansas, United States

CCOP - Wichita, Wichita, Kansas, United States

Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita, Kansas, United States

Cancer Center of Kansas, PA - Winfield, Winfield, Kansas, United States

Central Baptist Hospital, Lexington, Kentucky, United States

Lucille P. Markey Cancer Center at University of Kentucky, Lexington, Kentucky, United States

Ochsner Health Center - Bluebonnet, Baton Rouge, Louisiana, United States

Ochsner Health Center - Covington, Covington, Louisiana, United States

CCOP - Ochsner, New Orleans, Louisiana, United States

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States

Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center, Baltimore, Maryland, United States

Union Hospital of Cecil County, Elkton MD, Maryland, United States

Peninsula Regional Medical Center, Salisbury, Maryland, United States

Berkshire Hematology Oncology, PC, Pittsfield, Massachusetts, United States

Hickman Cancer Center at Bixby Medical Center, Adrian, Michigan, United States

Saint Joseph Mercy Cancer Center, Ann Arbor, Michigan, United States

CCOP - Michigan Cancer Research Consortium, Ann Arbor, Michigan, United States

Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn, Michigan, United States

Genesys Hurley Cancer Institute, Flint, Michigan, United States

Hurley Medical Center, Flint, Michigan, United States

Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods, Michigan, United States

Foote Memorial Hospital, Jackson, Michigan, United States

Borgess Medical Center, Kalamazoo, Michigan, United States

West Michigan Cancer Center, Kalamazoo, Michigan, United States

Bronson Methodist Hospital, Kalamazoo, Michigan, United States

Breslin Cancer Center at Ingham Regional Medical Center, Lansing, Michigan, United States

Sparrow Regional Cancer Center, Lansing, Michigan, United States

St. Mary Mercy Hospital, Livonia, Michigan, United States

Mercy Memorial Hospital - Monroe, Monroe, Michigan, United States

St. Joseph Mercy Oakland, Pontiac, Michigan, United States

Mercy Regional Cancer Center at Mercy Hospital, Port Huron, Michigan, United States

Seton Cancer Institute at Saint Mary's - Saginaw, Saginaw, Michigan, United States

Lakeside Cancer Specialists, PLLC, Saint Joseph, Michigan, United States

Providence Cancer Institute at Providence Hospital - Southfield Campus, Southfield, Michigan, United States

St. John Macomb Hospital, Warren, Michigan, United States

St. Joseph's Medical Center, Brainerd, Minnesota, United States

Fairview Ridges Hospital, Burnsville, Minnesota, United States

Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids, Minnesota, United States

CCOP - Duluth, Duluth, Minnesota, United States

St. Luke's Hospital Cancer Care Center, Duluth, Minnesota, United States

Fairview Southdale Hospital, Edina, Minnesota, United States

Fergus Falls Medical Group, PA, Fergus Falls, Minnesota, United States

Mercy and Unity Cancer Center at Unity Hospital, Fridley, Minnesota, United States

Hutchinson Area Health Care, Hutchinson, Minnesota, United States

HealthEast Cancer Care at St. John's Hospital, Maplewood, Minnesota, United States

Minnesota Oncology Hematology, PA - Maplewood, Maplewood, Minnesota, United States

Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis, Minnesota, United States

Hennepin County Medical Center - Minneapolis, Minneapolis, Minnesota, United States

Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale, Minnesota, United States

CCOP - Metro-Minnesota, Saint Louis Park, Minnesota, United States

Park Nicollet Cancer Center, Saint Louis Park, Minnesota, United States

United Hospital, Saint Paul, Minnesota, United States

St. Francis Cancer Center at St. Francis Medical Center, Shakopee, Minnesota, United States

Regions Hospital Cancer Care Center, St. Paul, Minnesota, United States

Lakeview Hospital, Stillwater, Minnesota, United States

Ridgeview Medical Center, Waconia, Minnesota, United States

Willmar Cancer Center at Rice Memorial Hospital, Willmar, Minnesota, United States

Minnesota Oncology Hematology, PA - Woodbury, Woodbury, Minnesota, United States

Goldschmidt Cancer Center, Jefferson City, Missouri, United States

Saint Luke's Cancer Institute at Saint Luke's Hospital, Kansas City, Missouri, United States

St. Joseph Medical Center, Kansas City, Missouri, United States

North Kansas City Hospital, Kansas City, Missouri, United States

Parvin Radiation Oncology, Kansas City, Missouri, United States

Heartland Hematology Oncology Associates, Incorporated, Kansas City, Missouri, United States

Research Medical Center, Kansas City, Missouri, United States

Saint Luke's East - Lee's Summit, Lee's Summit, Missouri, United States

Liberty Hospital, Liberty, Missouri, United States

Heartland Regional Medical Center, Saint Joseph, Missouri, United States

Saint Louis University Cancer Center, Saint Louis, Missouri, United States

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, Saint Louis, Missouri, United States

Missouri Baptist Cancer Center, Saint Louis, Missouri, United States

Comprehensive Cancer Care, PC, Saint Louis, Missouri, United States

CCOP - Cancer Research for the Ozarks, Springfield, Missouri, United States

Hulston Cancer Center at Cox Medical Center South, Springfield, Missouri, United States

CCOP - Montana Cancer Consortium, Billings, Montana, United States

St. Vincent Healthcare Cancer Care Services, Billings, Montana, United States

Hematology-Oncology Centers of the Northern Rockies - Billings, Billings, Montana, United States

Billings Clinic - Downtown, Billings, Montana, United States

Bozeman Deaconess Cancer Center, Bozeman, Montana, United States

St. James Healthcare Cancer Care, Butte, Montana, United States

Great Falls Clinic - Main Facility, Great Falls, Montana, United States

Sletten Cancer Institute at Benefis Healthcare, Great Falls, Montana, United States

St. Peter's Hospital, Helena, Montana, United States

Glacier Oncology, PLLC, Kalispell, Montana, United States

Kalispell Medical Oncology at KRMC, Kalispell, Montana, United States

Kalispell Regional Medical Center, Kalispell, Montana, United States

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula, Montana, United States

Cancer Resource Center - Lincoln, Lincoln, Nebraska, United States

CCOP - Missouri Valley Cancer Consortium, Omaha, Nebraska, United States

Immanuel Medical Center, Omaha, Nebraska, United States

Alegant Health Cancer Center at Bergan Mercy Medical Center, Omaha, Nebraska, United States

Creighton University Medical Center, Omaha, Nebraska, United States

Newark Beth Israel Medical Center, Newark, New Jersey, United States

Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees, New Jersey, United States

University of New Mexico Cancer Center, Albuquerque, New Mexico, United States

Roswell Park Cancer Institute, Buffalo, New York, United States

Charles R. Wood Cancer Center at Glens Falls Hospital, Glens Falls, New York, United States

NYU Cancer Institute at New York University Medical Center, New York, New York, United States

Nalitt Cancer Institute at Staten Island University Hospital, Staten Island, New York, United States

Presbyterian Cancer Center at Presbyterian Hospital, Charlotte, North Carolina, United States

Leo W. Jenkins Cancer Center at ECU Medical School, Greenville, North Carolina, United States

Kinston Medical Specialists, Kinston, North Carolina, United States

Iredell Memorial Hospital, Statesville, North Carolina, United States

Forsyth Regional Cancer Center at Forsyth Medical Center, Winston-Salem, North Carolina, United States

Wake Forest University Comprehensive Cancer Center, Winston-Salem, North Carolina, United States

CCOP - MeritCare Hospital, Fargo, North Dakota, United States

Mary Rutan Hospital, Bellefontaine, Ohio, United States

Adena Regional Medical Center, Chillicothe, Ohio, United States

Case Comprehensive Cancer Center, Cleveland, Ohio, United States

Riverside Methodist Hospital Cancer Care, Columbus, Ohio, United States

CCOP - Columbus, Columbus, Ohio, United States

Grant Medical Center Cancer Care, Columbus, Ohio, United States

Mount Carmel Health - West Hospital, Columbus, Ohio, United States

Doctors Hospital at Ohio Health, Columbus, Ohio, United States

Grandview Hospital, Dayton, Ohio, United States

Good Samaritan Hospital, Dayton, Ohio, United States

David L. Rike Cancer Center at Miami Valley Hospital, Dayton, Ohio, United States

CCOP - Dayton, Dayton, Ohio, United States

Grady Memorial Hospital, Delaware, Ohio, United States

Community Cancer Center, Elyria, Ohio, United States

Hematology Oncology Center, Elyria, Ohio, United States

Blanchard Valley Medical Associates, Findlay, Ohio, United States

Middletown Regional Hospital, Franklin, Ohio, United States

Wayne Hospital, Greenville, Ohio, United States

Charles F. Kettering Memorial Hospital, Kettering, Ohio, United States

Fairfield Medical Center, Lancaster, Ohio, United States

Lima Memorial Hospital, Lima, Ohio, United States

Strecker Cancer Center at Marietta Memorial Hospital, Marietta, Ohio, United States

Knox Community Hospital, Mount Vernon, Ohio, United States

Licking Memorial Cancer Care Program at Licking Memorial Hospital, Newark, Ohio, United States

Fisher-Titus Medical Center, Norwalk, Ohio, United States

St. Charles Mercy Hospital, Oregon, Ohio, United States

North Coast Cancer Care, Incorporated, Sandusky, Ohio, United States

Community Hospital of Springfield and Clark County, Springfield, Ohio, United States

Flower Hospital Cancer Center, Sylvania, Ohio, United States

Mercy Hospital of Tiffin, Tiffin, Ohio, United States

Toledo Hospital, Toledo, Ohio, United States

St. Vincent Mercy Medical Center, Toledo, Ohio, United States

Medical University of Ohio Cancer Center, Toledo, Ohio, United States

CCOP - Toledo Community Hospital, Toledo, Ohio, United States

St. Anne Mercy Hospital, Toledo, Ohio, United States

Toledo Clinic, Incorporated - Main Clinic, Toledo, Ohio, United States

UVMC Cancer Care Center at Upper Valley Medical Center, Troy, Ohio, United States

Fulton County Health Center, Wauseon, Ohio, United States

Mount Carmel St. Ann's Cancer Center, Westerville, Ohio, United States

Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia, Ohio, United States

Genesis - Good Samaritan Hospital, Zanesville, Ohio, United States

Oklahoma University Cancer Institute, Oklahoma City, Oklahoma, United States

Natalie Warren Bryant Cancer Center at St. Francis Hospital, Tulsa, Oklahoma, United States

Butler Memorial Hospital, Butler, Pennsylvania, United States

Riddle Memorial Hospital Cancer Center, Media, Pennsylvania, United States

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia, Pennsylvania, United States

Allegheny Cancer Center at Allegheny General Hospital, Pittsburgh, Pennsylvania, United States

UPMC Cancer Centers, Pittsburgh, Pennsylvania, United States

McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center, Reading, Pennsylvania, United States

Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center, Upland, Pennsylvania, United States

Bon Secours St. Francis Health System, Greenville, South Carolina, United States

CCOP - Greenville, Greenville, South Carolina, United States

Self Regional Cancer Center at Self Regional Medical Center, Greenwood, South Carolina, United States

Medical X-Ray Center, PC, Sioux Falls, South Dakota, United States

Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls, South Dakota, United States

Thompson Cancer Survival Center, Knoxville, Tennessee, United States

Parkland Memorial Hospital, Dallas, Texas, United States

Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas, Texas, United States

Joe Arrington Cancer Research and Treatment Center, Lubbock, Texas, United States

Sandra L. Maxwell Cancer Center, Cedar City, Utah, United States

Logan Regional Hospital, Logan, Utah, United States

Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden, Utah, United States

Utah Valley Regional Medical Center - Provo, Provo, Utah, United States

Dixie Regional Medical Center - East Campus, Saint George, Utah, United States

LDS Hospital, Salt Lake City, Utah, United States

Danville Regional Medical Center, Danville, Virginia, United States

Fredericksburg Oncology, Incorporated, Fredericksburg, Virginia, United States

Overlake Cancer Center at Overlake Hospital Medical Center, Bellevue, Washington, United States

Fred Hutchinson Cancer Research Center, Seattle, Washington, United States

Group Health Central Hospital, Seattle, Washington, United States

Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle, Washington, United States

Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital, Parkersburg, West Virginia, United States

Marshfield Clinic - Chippewa Center, Chippewa Falls, Wisconsin, United States

Marshfield Clinic Cancer Care at Regional Cancer Center, Eau Claire, Wisconsin, United States

Marshfield Clinic - Marshfield Center, Marshfield, Wisconsin, United States

Medical College of Wisconsin Cancer Center, Milwaukee, Wisconsin, United States

Marshfield Clinic - Lakeland Center, Minocqua, Wisconsin, United States

Ministry Medical Group at Saint Mary's Hospital, Rhinelander, Wisconsin, United States

Marshfield Clinic - Indianhead Center, Rice Lake, Wisconsin, United States

Marshfield Clinic at Saint Michael's Hospital, Stevens Point, Wisconsin, United States

Marshfield Clinic - Weston Center, Weston, Wisconsin, United States

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids, Wisconsin, United States

Welch Cancer Center at Sheridan Memorial Hospital, Sheridan, Wyoming, United States

Contact Details

Name: Norman Wolmark, MD

Affiliation: NSABP Foundation Inc

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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