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Spots Global Cancer Trial Database for Circulating Tumour DNA (ctDNA) as a Prognostic and Predictive Marker in Colorectal Cancer - a Pilot Study

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Trial Identification

Brief Title: Circulating Tumour DNA (ctDNA) as a Prognostic and Predictive Marker in Colorectal Cancer - a Pilot Study

Official Title: A Pilot Study Investigating the Feasibility to Perform Prospective Circulating Tumor DNA (ctDNA) Profiling in Patients With Colorectal Cancer

Study ID: NCT04726800

Interventions

Study Description

Brief Summary: In clinical practice, there are currently no biomarkers that can guide colorectal cancer treatment in the primary and curative setting. Improved biomarker-based adjuvant treatments would be of greatest value in order to reduce the risk of relapse. There are reasons to believe that measurements of circulating tumor DNA (ctDNA) in plasma could be used to monitor minimal residual disease after surgery. To address this question, a pilot study was conducted with the purpose to demonstrate the feasibility to perform prospective profiling of ctDNA in a cohort of patients with colorectal cancer stage I-III using the already created Nordic infrastructure for clinical research built up for the ALASCCA trial. If the pilot study proves successful, a large randomised controlled Nordic multicenter study is planned where patients with positive ctDNA 4-6 weeks after radical surgery will be randomised to chemotherapy and/or a biologic agent.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Akershus Univeristy Hospital, Oslo, , Norway

Sahlgrenska University Hospital, Göteborg, , Sweden

Skaraborg Hospital, Skövde, , Sweden

Capio Sankt Göran Hospital, Stockholm, , Sweden

Danderyd University Hospital, Stockholm, , Sweden

Ersta Hospital, Stockholm, , Sweden

Karolinska University Hospital, Stockholm, , Sweden

South Hospital, Stockholm, , Sweden

Contact Details

Name: Anna Martling, Professor

Affiliation: Karolinska Institutet

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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