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Spots Global Cancer Trial Database for Impact of Pre-operative Bevacizumab on Complications After Resection of Colorectal Liver Metastases

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Trial Identification

Brief Title: Impact of Pre-operative Bevacizumab on Complications After Resection of Colorectal Liver Metastases

Official Title: Impact of Pre-operative Bevacizumab on Complications After Resection of Colorectal Liver Metastases A Case Matched Control Study

Study ID: NCT00875147

Interventions

bevacizumab

Study Description

Brief Summary: Hypothesis of the study: Neoadjuvant chemotherapy with Bevacizumab impairs postoperative outcome after resection of colorectal liver metastases.

Detailed Description: Bevacizumab is a humanized monoclonal antibody against vascular endothelial growth factor (VEGF) increasingly added to other drugs in the treatment of colorectal cancer. Bev is typically used in combination with other chemotherapeutic agents such as oxaliplatin, irinotecan, leucovorin and 5-fluorouracil (5-FU) for treatment of patients with CRLM. The objective of this study was to assess the impact of neoadjuvant bevacizumab on clinical outcome after hepatectomy of colorectal liver metastases (CRLM). Patients, who underwent liver resection due to colorectal liver metastases after neoadjuvant chemotherapy, operated between 2005 and 2007 will be evaluated retrospectively. The patients will be distributed in two groups, either with or without bevacicumab. Outcome parameters are mortality, complications, hospital stay and ICU stay. To increase the power of the study the total number of patients will be increased by adding patients from other centers. Results will be adjusted for the propensity of developing complications.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Centre de Chirurgie Viscérale et de Transplantation, Hautepierre Hospital, Strasbourg, , France

Division of hepato-biliary-pancreatic surgery. Department of surgery, "Josep Tureta" Hospital, Girona, , Spain

University Hospital of Zurich, Zurich, , Switzerland

Contact Details

Name: Stefan Breitenstein, MD

Affiliation: Departement of Visceral and Transplantation Surgery of University hospital of Zurich

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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