Spots Global Cancer Trial Database for Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer
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Trial Identification
Brief Title: Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer
Official Title:
Study ID: NCT00220246
Conditions
Interventions
Study Description
Brief Summary: Two major genetic pathways leading to colorectal carcinoma can well be distinguished; the 'suppressor pathway', which is characterized by inactivation of tumor-suppressor genes and the 'mutator pathway', which is characterized by microsatellite instability. The purpose of this study is to explore a third putative pathway; microsatellite and chromosome stable colorectal cancer where an alternative cancer-causative mechanism might play a role.
Detailed Description: Patients with familial colorectal cancer will be characterized with respect to family history, medical history and demographic characteristics. The histopathology of the tumors will be reviewed. Tumor specimens will be analysed on molecular defects.
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Radboud University, Nijmegen, , Netherlands
Contact Details
Name: Nicoline Hoogerbrugge, MD, PhD
Affiliation: Department of Human Genetics, Radboud University Nijmegen Medical Center
Role: PRINCIPAL_INVESTIGATOR
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