Spots Global Cancer Trial Database for microsatellite instability
Every month we try and update this database with for microsatellite instability cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Durvalumab in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer | NCT02966587 | Castration Leve... Hormone-Resista... Microsatellite ... | Durvalumab Laboratory Biom... | 18 Years - | University of Washington | |
| Dynamics of MSI and Genomic Profile of Colorectal Cancer In the Course of Immune Checkpoint Inhibitor Therapy | NCT06414304 | Colorectal Canc... Colorectal Canc... MSI-H Colorecta... dMMR Colorectal... Cancer Colon Adenocarc... | 18 Years - | OncoAtlas LLC | ||
| Frequency of Endometrial Cancer Precursors Associated With Lynch Syndrome | NCT05257057 | Lynch Syndrome Endometrial Can... Endometrial Hyp... Mismatch Repair... Microsatellite ... | Immunohistochem... | 18 Years - 99 Years | WellSpan Health | |
| Long-term, Non-interventional, Observational Study Following Treatment With Fate Therapeutics FT500 Cellular Immunotherapy | NCT04106167 | Advanced Solid ... Lymphoma Gastric Cancer Colorectal Canc... Head and Neck C... Squamous Cell C... EGFR Positive S... HER2-positive B... Hepatocellular ... Small-cell Lung... Renal Cell Carc... Pancreas Cancer Melanoma NSCLC Urothelial Carc... Cervical Cancer Microsatellite ... Merkel Cell Car... | Allogeneic natu... | 18 Years - | Fate Therapeutics | |
| APL-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors | NCT03053466 | Solid Tumor Microsatellite ... Mismatch Repair... Cancer of Unkno... | APL-501 | 18 Years - | Apollomics (Australia) Pty. Ltd. | |
| Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers | NCT03935893 | Gastric Cancer Colorectal Canc... Pancreatic Canc... Sarcoma Mesothelioma Neuroendocrine ... Squamous Cell C... Merkel Cell Car... Mismatch Repair... Microsatellite ... | Tumor Infiltrat... Fludarabine + C... | 18 Years - 75 Years | University of Pittsburgh | |
| Microsatellite Instability in Colorectal Cancers | NCT05162248 | Colorectal Canc... Colorectal Carc... Microsatellite ... Microsatellite ... Microsatellite ... | Microsatellite ... | 18 Years - 100 Years | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey | |
| Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer | NCT00220246 | Colorectal Neop... | - 51 Years | Radboud University Medical Center | ||
| Dynamics of MSI and Genomic Profile of Colorectal Cancer In the Course of Immune Checkpoint Inhibitor Therapy | NCT06414304 | Colorectal Canc... Colorectal Canc... MSI-H Colorecta... dMMR Colorectal... Cancer Colon Adenocarc... | 18 Years - | OncoAtlas LLC | ||
| Durvalumab in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer | NCT02966587 | Castration Leve... Hormone-Resista... Microsatellite ... | Durvalumab Laboratory Biom... | 18 Years - | University of Washington | |
| Molecular Biology of Anal Cancer in HIV-Positive Patients | NCT00952874 | Carcinoma HIV Infections | 20 Years - 80 Years | University Hospital, Geneva | ||
| Long-term, Non-interventional, Observational Study Following Treatment With Fate Therapeutics FT500 Cellular Immunotherapy | NCT04106167 | Advanced Solid ... Lymphoma Gastric Cancer Colorectal Canc... Head and Neck C... Squamous Cell C... EGFR Positive S... HER2-positive B... Hepatocellular ... Small-cell Lung... Renal Cell Carc... Pancreas Cancer Melanoma NSCLC Urothelial Carc... Cervical Cancer Microsatellite ... Merkel Cell Car... | Allogeneic natu... | 18 Years - | Fate Therapeutics | |
| Detect Microsatellite Instability Status in Blood Sample of Advanced Colorectal Cancer Patients by Next-Generation Sequencing | NCT03561350 | Colorectal Neop... | 18 Years - | Shanghai Minimally Invasive Surgery Center | ||
| A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of RO7589831 in Participants With Advanced Solid Tumors | NCT06004245 | Advanced Solid ... | RO7589831 | 18 Years - | Hoffmann-La Roche | |
| Clinicopathological Importance of Colorectal Medullary Carcinoma: Retrospective Cohort Study | NCT03774862 | Colorectal Medu... | - | V.K.V. American Hospital, Istanbul | ||
| FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors | NCT03841110 | Advanced Solid ... Lymphoma Gastric Cancer Colorectal Canc... Head and Neck C... Squamous Cell C... EGFR Positive S... HER2-positive B... Hepatocellular ... Small Cell Lung... Renal Cell Carc... Pancreas Cancer Melanoma NSCLC Urothelial Carc... Cervical Cancer Microsatellite ... Merkel Cell Car... | FT500 Nivolumab Pembrolizumab Atezolizumab Cyclophosphamid... Fludarabine IL-2 | 18 Years - | Fate Therapeutics | |
| QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors | NCT03228667 | Non-Small Cell ... Small Cell Lung... Urothelial Carc... Head and Neck S... Merkel Cell Car... Melanoma Renal Cell Carc... Gastric Cancer Cervical Cancer Hepatocellular ... Microsatellite ... Mismatch Repair... Colorectal Canc... | N-803 + Pembrol... N-803 + Nivolum... N-803 + Atezoli... N-803 + Aveluma... N-803 + Durvalu... N-803 + Pembrol... N-803 + Nivolum... N-803 + Atezoli... N-803 + Aveluma... N-803 + Durvalu... | 18 Years - | ImmunityBio, Inc. | |
| APL-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors | NCT03053466 | Solid Tumor Microsatellite ... Mismatch Repair... Cancer of Unkno... | APL-501 | 18 Years - | Apollomics (Australia) Pty. Ltd. | |
| MSI in Circulatory DNA of Endometrial Cancer | NCT03744962 | Microsatellite ... Lynch Syndrome Endometrial Can... Circulating Tum... | - | Peking Union Medical College Hospital | ||
| National Cohort of Colorectal Cancers With Microsatellite Instability | NCT05511688 | Colorectal Canc... Microsatellite ... | 18 Years - | Federation Francophone de Cancerologie Digestive | ||
| Avelumab Plus 5-FU Based Chemotherapy as Adjuvant Treatment for Stage 3 MSI-High or POLE Mutant Colon Cancer | NCT03827044 | POLE Exonucleas... Microsatellite ... Stage III Colon... | Avelumab | 18 Years - | Royal Marsden NHS Foundation Trust | |
| QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors | NCT03228667 | Non-Small Cell ... Small Cell Lung... Urothelial Carc... Head and Neck S... Merkel Cell Car... Melanoma Renal Cell Carc... Gastric Cancer Cervical Cancer Hepatocellular ... Microsatellite ... Mismatch Repair... Colorectal Canc... | N-803 + Pembrol... N-803 + Nivolum... N-803 + Atezoli... N-803 + Aveluma... N-803 + Durvalu... N-803 + Pembrol... N-803 + Nivolum... N-803 + Atezoli... N-803 + Aveluma... N-803 + Durvalu... | 18 Years - | ImmunityBio, Inc. | |
| Detect Microsatellite Instability Status in Blood Sample of Advanced Colorectal Cancer Patients by Next-Generation Sequencing | NCT03561350 | Colorectal Neop... | 18 Years - | Shanghai Minimally Invasive Surgery Center | ||
| Genetic Mutation in Recurrent Cervical Cancer | NCT04191226 | Recurrent Cervi... Nucleotide Vari... Copy Number Var... Insertion-delet... Genomic Structu... Total Mutation ... Microsatellite ... PD-1 PD-L1 | Multi-gene pane... | 18 Years - | Peking Union Medical College Hospital | |
| Long-term, Non-interventional, Observational Study Following Treatment With Fate Therapeutics FT500 Cellular Immunotherapy | NCT04106167 | Advanced Solid ... Lymphoma Gastric Cancer Colorectal Canc... Head and Neck C... Squamous Cell C... EGFR Positive S... HER2-positive B... Hepatocellular ... Small-cell Lung... Renal Cell Carc... Pancreas Cancer Melanoma NSCLC Urothelial Carc... Cervical Cancer Microsatellite ... Merkel Cell Car... | Allogeneic natu... | 18 Years - | Fate Therapeutics | |
| Implementation of a New Strategy to Identify HNPCC Patients | NCT00141466 | Colorectal Neop... Hereditary Nonp... | Education for p... Distribution of... Feedback for pr... Reminders for p... | - | Radboud University Medical Center | |
| Molecular Characteristics of Early-onset Compared With Late-onset Colorectal Cancer | NCT06238193 | Colorectal Canc... Microsatellite ... | 18 Years - 80 Years | The First Affiliated Hospital with Nanjing Medical University | ||
| Frequency of Endometrial Cancer Precursors Associated With Lynch Syndrome | NCT05257057 | Lynch Syndrome Endometrial Can... Endometrial Hyp... Mismatch Repair... Microsatellite ... | Immunohistochem... | 18 Years - 99 Years | WellSpan Health | |
| Avelumab Plus 5-FU Based Chemotherapy as Adjuvant Treatment for Stage 3 MSI-High or POLE Mutant Colon Cancer | NCT03827044 | POLE Exonucleas... Microsatellite ... Stage III Colon... | Avelumab | 18 Years - | Royal Marsden NHS Foundation Trust | |
| Study of RP1 Monotherapy and RP1 in Combination With Nivolumab | NCT03767348 | Cancer Melanoma (Skin) Mismatch Repair... Microsatellite ... Non-melanoma Sk... Cutaneous Melan... NSCLC | RP1 nivolumab | 18 Years - | Replimune Inc. | |
| Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer | NCT03047226 | Lynch Syndrome | next-generation... | - | Second Affiliated Hospital, School of Medicine, Zhejiang University | |
| QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors | NCT03228667 | Non-Small Cell ... Small Cell Lung... Urothelial Carc... Head and Neck S... Merkel Cell Car... Melanoma Renal Cell Carc... Gastric Cancer Cervical Cancer Hepatocellular ... Microsatellite ... Mismatch Repair... Colorectal Canc... | N-803 + Pembrol... N-803 + Nivolum... N-803 + Atezoli... N-803 + Aveluma... N-803 + Durvalu... N-803 + Pembrol... N-803 + Nivolum... N-803 + Atezoli... N-803 + Aveluma... N-803 + Durvalu... | 18 Years - | ImmunityBio, Inc. | |
| Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact | NCT03447431 | Colorectal Canc... Microsatellite ... | - | Assistance Publique - Hôpitaux de Paris | ||
| Non-Invasive Diagnosis of Endometrial Cancer | NCT05737797 | Endometrial Can... | cervical cytolo... | 18 Years - | Assistance Publique - Hôpitaux de Paris | |
| TremelImumab aNd Durvalumab For the Non-operatIve Management (NOM) of MSI-high Resectable GC/GEJC. | NCT04817826 | Gastric Cancer Microsatellite ... | Durvalumab Tremelimumab | 18 Years - | Gruppo Oncologico del Nord-Ovest | |
| Detection of MSI in Circulating Tumor DNA of Colorectal Carcinoma Patients | NCT03594448 | Microsatellite ... Colorectal Canc... | Specimen Collec... Serial Liquid B... | 18 Years - | University of Southern California | |
| Postoperative Radiotherapy According to Molecular Analysis of Surgical Margins of Oral and Oropharyngeal SCC | NCT00232960 | Oral Cancer Oropharynx Canc... | Radiotherapy 50... | 18 Years - | Gustave Roussy, Cancer Campus, Grand Paris | |
| Genetic Mutation in Epithelial Ovarian Cancer | NCT04191252 | Epithelial Ovar... Nucleotide Vari... Copy Number Var... Insertion-delet... Genomic Structu... Total Mutation ... Microsatellite ... PD-1 PD-L1 | A multi-gene pa... | 18 Years - | Peking Union Medical College Hospital | |
| The Relationship Between Microsatellite Instability and Efficacy of Fluorouracil Based Adjuvant Chemotherapy in Gastric Cancer After Operation | NCT03485196 | Gastric Cancer | Microsatellite ... | 18 Years - 80 Years | Affiliated Hospital of Qinghai University |
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