Spots Global Cancer Trial Database for A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
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Trial Identification
Brief Title: A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
Official Title: An Open-label Phase 1 Study to Investigate SGN-CEACAM5C in Adults With Advanced Solid Tumors
Study ID: NCT06131840
Interventions
Study Description
Brief Summary: This clinical trial is studying advanced solid tumors. Solid tumors are cancers that start in a part of your body like your lungs or liver instead of your blood. Once tumors have grown bigger in one place but haven't spread, they're called locally advanced. If your cancer has spread to other parts of your body, it's called metastatic. When a cancer has gotten so big it can't easily be removed or has spread to other parts of the body, it is called unresectable. These types of cancer are harder to treat. Patients in this study must have cancer that has come back or did not get better with treatment. Patients must have a solid tumor cancer that can't be treated with standard of care drugs. This clinical trial uses an experimental drug called SGN-CEACAM5C. SGN-CEACAM5C is a type of antibody-drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill them. They may also stick to some normal cells. This study will test the safety of SGN-CEACAM5C in participants with solid tumors that are hard to treat or have spread throughout the body. This study will have 3 parts. Part A and Part B of the study will find out how much SGN-CEACAM5C should be given to participants. Part C will use the information from Parts A and B to see if SGN-CEACAM5C is safe and if it works to treat solid tumor cancers.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
City of Hope, Duarte, California, United States
University of Colorado Hospital / University of Colorado, Aurora, Colorado, United States
Florida Cancer Specialists - Lake Nona, Orlando, Florida, United States
Johns Hopkins Medical Center, Baltimore, Maryland, United States
South Texas Accelerated Research Therapeutics Midwest, Grand Rapids, Michigan, United States
Tennessee Oncology-Nashville/Sarah Cannon Research Institute, Nashville, Tennessee, United States
MD Anderson Cancer Center / University of Texas, Houston, Texas, United States
South Texas Accelerated Research Therapeutics, San Antonio, Texas, United States
START Mountain Region, West Valley City, Utah, United States
Contact Details
Name: Medical Monitor
Affiliation: Seagen Inc.
Role: STUDY_DIRECTOR
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