Spots Global Cancer Trial Database for Intratumoral Budding (ITB) in Preoperative Biopsies of Colon and Rectal Cancer
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Trial Identification
Brief Title: Intratumoral Budding (ITB) in Preoperative Biopsies of Colon and Rectal Cancer
Official Title: Assessment of Intratumoral Budding (ITB) in Preoperative Biopsies of Colon and Rectal Cancer Patients: a Prospective Observational Study
Study ID: NCT03336658
Conditions
Interventions
Study Description
Brief Summary: All the preoperative biopsies of patients suffering colorectal cancer (CRC) will be immunohistochemically stained with a pancytokeratin marker to detect Tumor buds. then, the intratumoral buds (ITB) in the densest Region of Tumor buds, namely the "hot spot" will be counted. Subsequently, the probability of N stage (lymphnodes), M stage (metastases) and disease free survival (DFS) will be calculated based on an existing logistic Regression model already developed by our previous retrospective work. Additionally, a Standardisation of ITB using a well- established Software will develop an algorithm which will help to eliminate inter- observer variability of Tumor budding Counts.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Department of visceral surgery and transplant surgery, Berne University Hospital, Berne, , Switzerland
Contact Details
Name: Beat Schnüriger, PD
Affiliation: Insel Gruppe AG, University Hospital Bern
Role: PRINCIPAL_INVESTIGATOR
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