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Spots Global Cancer Trial Database for Neoadjuvant Pembrolizumab in Cutaneous Squamous Cell Carcinoma

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Neoadjuvant Pembrolizumab in Cutaneous Squamous Cell Carcinoma

Official Title: A Phase 2 Study of De-escalation in Resectable, Locally Advanced Cutaneous Squamous Cell Carcinoma With the Use of Neoadjuvant Pembrolizumab - DESQUAMATE

Study ID: NCT05025813

Interventions

Pembrolizumab

Study Description

Brief Summary: Cutaneous Squamous Cell Carcinoma (cSCC) is typically associated with a high tumour mutation burden, with the majority caused by Ultraviolet (UV) exposure (Pickering et al., 2014). The use of this trial using neoadjuvant Pembrolizumab in patients with cSCC who will otherwise undergo highly morbid radical surgical resection has multiple potential advantages, including: 1. Reduction in surgical and radiotherapy morbidity by reducing tumour burden and allowing the appropriate selection of patients to undergo post-operative radiotherapy; 2. Provision of immediate information about pathological response and 3. Access to tissue to provide insight into resistance mechanisms and identification of biomarkers of response. The Investigators hypothesized that the use of neoadjuvant Pembrolizumab could reduce tumour burden allowing appropriate selection of patients undergoing radical surgical resection and adjuvant radiotherapy.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia

Royal Brisbane and Women's Hospital, Herston, Queensland, Australia

Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

Contact Details

Name: Rahul Ladwa, MD

Affiliation: Queensland Health

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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